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Abstract
The Immunomodulating Activity of Derris scandens Benth. in Normal Healthy Volunteers
‡
†
Busarawan Sriwanthana*, Pranee Chavalittumrong Boonyanee Suphaphon , Prapai Wongsinkongman ,
†
Rungrueng Kijphati*
*National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Department of Medical
†
Sciences, Ministry of Public Health, Medicinal Plant Research Institute, Department of Medical Sciences, Ministry
‡
of Public Health
This clinical trial was performed in 47 healthy volunteers primarily to investigate the safety of Derris
scandens Benth., as well as to assess preliminarily its effects on the immune system. The volunteers received
400 mg/day of D. scandens hydroalcoholic extract (200 mg b.i.d.) for two months. None of the subjects re-
ported any major side effects throughout the study. It was found that any significant changes in hematological
and biochemical parameters were within the normal limits. Nonetheless, there was significant rise in the
frequency of subjects showing increasing amounts of IL-2 and γγ γγ γ-IFN after administration. Our results sug-
gested that the hydroalcoholic extract of D. scandens at the dose of 400 mg/day given to normal volunteers for
two months was safe and could induce the secretion of cytokines that might help in modulating immune
responses.
Key words: Derris scandens, clinical trial, immune response, IL-2, γ γ γ γ γ - IFN