Page 68 - journal-7-1-Full

ı «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë ˜©∫—∫∑’Ë Ò ¡°√“§¡-‡¡…“¬π ÚııÚ

IFN ´÷Ë߇ªìπ°“√∑¥ Õ∫ƒ∑∏‘Ï¢Õß “√ °—¥μàÕ°“√À≈—ËߢÕß ®—π∑√å «à“ß ‰¥â™à«¬„π°“√μ√«®∑“ßÀâÕߪؑ∫—μ‘°“√·≈–°“√

cytokines ®“°‡´≈≈å„π√–∫∫¿Ÿ¡‘§ÿâ¡°—π ‚¥¬∑’Ë IL-2 ∑”Àπâ“∑’Ë ∫—π∑÷°¢âÕ¡Ÿ≈. §ÿ≥»‘√‘√—μπå ≈‘°“ππ∑å °ÿ≈ ‚√ß欓∫“≈
‡°’ˬ«¢âÕß°—∫°“√‡®√‘≠‡μ‘∫‚μ·≈–¡’º≈μàÕ°“√‡ª≈’ˬπ·ª≈ß ∫”√“»π√“¥Ÿ√ „À⧫“¡Õπÿ‡§√“–Àå°“√μ√«®«‘∏’ Flowcytometer.
¢Õ߇´≈≈å„π√–∫∫¿Ÿ¡‘§ÿâ¡°—π‚¥¬‡©æ“–μàÕ‡´≈≈å∑’, ∫’, NK ºŸâ™à«¬»“ μ√“®“√¬å ¥√. »—°¥‘Ï™—¬ «‘∑¬“Õ“√’¬å°ÿ≈ §≥–‡¿ —™
Ú˜
·≈–‚¡‚π‰´μå IL-Ù ‡ªìπ “√∑’˙૬‡ √‘¡°“√ √â“ß·Õπμ‘- »“ μ√å ¡À“«‘∑¬“≈—¬π‡√»«√‰¥â°√ÿ≥“∑”°“√μ√«®°“√
Ú¯-Û
∫Õ¥’ à«π γ-IFN √â“ß®“°≈‘¡‚ø‰´μå ∑’ ·≈–‡´≈≈å NK °√–®“¬μ—«¢Õ߬“. √Õß»“ μ√“®“√¬å ¥√.Õ√ÿ≥æ√ Õ‘∞√—μπå
‡¡◊ËÕ∂Ÿ°°√–μÿâπ¥â«¬‰¡‚쇮πÀ√◊Õ·Õπ쑇®π ·≈–¡’ƒ∑∏‘ÏμàÕ §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬ ߢ≈“π§√‘π∑√剥â°√ÿ≥“™à«¬

√–∫∫¿Ÿ¡‘§ÿâ¡°—π„π°“√ª√—∫‡ª≈’ˬπ°“√μÕ∫ πÕß∑“ß¿Ÿ¡‘§ÿâ¡°—π μ√«®§à“Õπÿ¡Ÿ≈Õ‘ √–.
Úˆ,ÛÒ
(immunomodulatory effect) ‚¥¬‡©æ“–‡´≈≈å NK ·≈–
∑’-≈‘¡‚ø‰´μå™π‘¥‡ªìπæ‘…μàÕ‡´≈≈å.
„π°“√»÷°…“π’Èæ∫«à“À≈—ß°‘π “√ °—¥‡∂“«—≈¬å‡ª√’¬ß
ª√‘¡“≥ IL-2 ·≈– γ-IFN „π´’√—Ë¡¢ÕßÕ“ “ ¡—§√∫“ß√“¬‡æ‘Ë¡

¢÷Èπ®“°°àÕπ°‘π “√ °—¥ ·≈–‰¡àæ∫«à“¡’ª√‘¡“≥ IL-4 ‡æ‘Ë¡¢÷Èπ. ‡Õ° “√Õâ“ßÕ‘ß
Ò. ‡μÁ¡ ¡‘μ‘π—π∑å. ™◊ËÕæ√√≥‰¡â·Ààߪ√–‡∑»‰∑¬.©∫—∫·°â‰¢‡æ‘Ë¡‡μ‘¡.
º≈∑’ˉ¥âπ’ÈÕ“®°≈à“«‰¥â«à“ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß¡’ƒ∑∏‘ÏμàÕ
°√ÿ߇∑æœ: ∫√‘…—∑ª√–™“™π°”®—¥; ÚıÙÙ Àπâ“ Ò¯Û-Ù.
√–∫∫¿Ÿ¡‘§ÿâ¡°—π¢Õß√à“ß°“¬ ‚¥¬∑’Ë “¡“√∂‡Àπ’ˬ«π”„À⇰‘¥
Ú. 懬“«å ‡À¡◊Õπ«ß»å≠“μ‘. ¡ÿπ‰æ√°â“«„À¡à (·°â‰¢ª√—∫ª√ÿß®“°μ”√“
°“√À≈—ËߢÕß IL-2 ·≈– γ-IFN ´÷Ë߇ªìπ»—¬‚∑‰•πå ∑’˙૬§«∫§ÿ¡ «‘∑¬“»“ μ√å ¡ÿπ‰æ√). °√ÿ߇∑æœ: ∫√‘…—∑ ∑’ æ’ æ√‘Èπ∑å ®”°—¥; ÚıÛ˜.
Û. ¡“§¡ ¡ÿπ‰æ√·Ààߪ√–‡∑»‰∑¬. ß“ππ‘∑√√»°“√ ¡ÿπ‰æ√ §√—Èß∑’Ë Ú.
·≈–‡ √‘¡°“√∑”ß“π¢Õ߇´≈≈å„π√–∫∫¿Ÿ¡‘§ÿâ¡°—π.
°√ÿ߇∑æœ: »√’‡¡◊Õß°“√æ‘¡æå; ÚıÒ˘.
Ù. ¡“§¡‚√߇√’¬π·æ∑¬å·ºπ‚∫√“≥. ª√–¡«≈ √√æ§ÿ≥¬“‰∑¬ ¿“§ Ú.
√ÿª æ√–π§√: ”π—°«—¥æ√–‡™μÿæπœ («—¥‚æ∏‘Ï) ∑à“‡μ’¬π; ÚıÒ.
ı. ®‘π¥“æ√ ¿Ÿ√‘æ—≤π“«ß…å. ‡¿ —™‡«∑°—∫μ”√“¬“·ºπ‚∫√“≥. °√ÿ߇∑æœ:
º≈°“√»÷°…“ª√– ‘∑∏‘º≈¢Õ߇∂“«—≈¬å‡ª√’¬ß„πÕ“ “ ¡—§√ ‚√ßæ‘¡æåÕߧ尓√ ߇§√“–Àå∑À“√ºà“π»÷°; ÚıÛ˘.
ˆ. «ÿ≤‘ «ÿ≤‘∏√√¡‡«™. “√“πÿ°√¡ ¡ÿπ‰æ√ √«¡À≈—°‡¿ —™°√√¡‰∑¬.
√–¬–∑’Ë Ú π’È · ¥ß„Àâ‡ÀÁπ«à“‡¡◊ËÕ°‘π “√ °—¥‡∂“«—≈¬å‡ª√’¬ß
°√ÿ߇∑æœ: ‚Õ ‡Õ æ√‘Èπμ‘Èß ‡Œâ“ å; ÚıÙ.
¢π“¥«—π≈– Ù ¡°. π“π Ú ‡¥◊Õπ ‰¡àæ∫§«“¡º‘¥ª√°μ‘ ˜. Rao MN, Krupadanam GLD, Srimannarayana G. Four isoflavones and
two 3-aryl coumarins from stems of Derris scandens. Phytochem
¢Õß√–∫∫μà“ßÊ ¢Õß√à“ß°“¬ ·≈–æ∫«à“ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß
1994;37:267-9.
‡æ‘Ë¡°“√À≈—ËߢÕß IL-2 ·≈– γ-IFN „πÕ“ “ ¡—§√∫“ß√“¬ · ¥ß ¯. Sekine T, Inagaki M, Koseki T, Murakoshi I, Fuji Y, Yamamoto K, et al.
Ruangrungsi N and Ikegami F. Antifungal constituents of Thai medicinal
«à“ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß¡’§«“¡ª≈Õ¥¿—¬·≈–¡’·π«‚π⡇ªìπ
plants, Derris scandens and Rauwolfia verticillata. Current Advances
immunomodulator §◊Õ¡’§ÿ≥ ¡∫—쑪√—∫‡ª≈’ˬπ°“√μÕ∫ in Natural Product Research. The Third NRCT-JSPS joint seminar.
Bangkok, Thailand. 1996;229-5.
πÕß∑“ß¿Ÿ¡‘§ÿâ¡°—π. ·μà‚¥¬∑’Ë°“√»÷°…“π’ȇªìπ°“√»÷°…“∑“ß
˘. Sekine T, Inagaki M, Ikegami F, Fuji Y, Ruangrungsi N. Six
‡«™°√√¡„π§π ÿ¢¿“楒 ®÷ߧ«√®–¡’°“√»÷°…“‡æ‘Ë¡‡μ‘¡À√◊Õ
deprenylisoflavones, derrisisoflavones A-F, from Derris scandens.
»÷°…“„πºŸâ∑’Ë¡’§«“¡∫°æ√àÕߢÕß√–∫∫¿Ÿ¡‘§ÿâ¡°—π ‡æ◊ËÕ®–‰¥â Phytochem 1999;52:87-94.
Ò. Rukachaisirikul V, Sukpondma Y, Jansakul C, Taylor WC. Isoflavone
∑√“∫ª√– ‘∑∏‘º≈∑’Ë™—¥‡®π¢÷Èπ„π¥â“π°“√‡ √‘¡¿Ÿ¡‘§ÿâ¡°—π®“°
glycosides from Derris scandens. Phytochem 2002;60:827-34.
°“√„™â‡∂“«—≈¬å‡ª√’¬ßμàÕ‰ª. ÒÒ. Dianpeng L, Mingan O, Jansakul C, Chongren Y. Two isoflavonoid
glycosides from Derris scandens. Yaoxue Xuebao 1999;34:43-5.
ÒÚ. Laupattarakasem P, Houghton PJ, Hoult JR. Anti-inflammatory
°‘μμ‘°√√¡ª√–°“»
isoflavonoids from the stems of Derris scandens. Planta Med 2004;70:
496-501.
ß“π«‘®—¬π’ȉ¥â√—∫∑ÿπÕÿ¥Àπÿπ°“√«‘®—¬‡æ◊ËÕæ—≤𓇻√…∞°‘®
ÒÛ. Falshaw CP, Harmer RA, Ollis WD, Wheeler RE, Lalitha VR, Rao
·≈– —ߧ¡¥â«¬«‘∑¬“»“ μ√å·≈–‡∑§‚π‚≈¬’®“° ”π—°ß“π§≥– NVS. natural occurance of 3-aryl-4-hydroxycoumarin. II. Phytochemical
examination of Derris scandens. J Chem Soc C 1969;3:374-82.
°√√¡°“√«‘®—¬·Ààß™“μ‘ ª√–®”ß∫ª√–¡“≥ªï ÚıÙ˜.
ÒÙ. Senegupta P, Das PB, Saha SK. Triterpenes from Derris scandens
§ÿ≥«’≥“ μ√’· ß»√’ §ÿ≥∫ß°™ ®‘μ®—°√ ·≈–§ÿ≥«√“æ√√≥ (Roxb.) benth. J Indian Chem Soc 1971;48:95-6.