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Journal of Thai Traditional & Alternative Medicine Vol. 7 No. 1 January-April 2009 ı˜

¡“μ√∞“π¢ÕßπÈ”Àπ—°‡∑à“°—∫ Ù˘ı.Û ¡°., Ù˘ˆ.ˆ˘ ¡°. ·≈– «‘∑¬“∫“ß§à“¡’°“√‡ª≈’ˬπ·ª≈ßÕ¬à“ß¡’π—¬ ”§—≠ §◊Õª√‘¡“≥

˘˜.¯ ¡°., ˘˜.¯ ¡°. μ“¡«‘∏’ Thai Pharmacopoeia ‡¡Á¥‡≈◊Õ¥·¥ß≈¥≈ß„π —ª¥“Àå∑’Ë Ú, Ù, ˆ, ¯ ·≈– ÒÚ,
1997 Volume II Part 1. Œ’‚¡‚°≈∫‘π≈¥≈ß„π —ª¥“Àå∑’Ë Ù, ˆ, ¯, ·≈–Œ’¡“‚μ§√‘μ ÒÚ%
º≈∑¥ Õ∫°“√°√–®“¬°“√·μ°μ—«¢Õß·§ª´Ÿ≈‚¥¬°“√ ≈¥≈ß„π —ª¥“Àå∑’Ë Ú, Ù, ˆ, ¯ ·≈–ÒÚ (μ“√“ß∑’Ë Ò)

ÿࡧ√—Èß≈– Ú ·§ª´Ÿ≈ ®”π«π Ú ™ÿ¥ æ∫«à“¡’§à“‡©≈’ˬ¢Õß
∑“ß™’«‡§¡’¢Õß´’√—Ë¡
°“√°√–®“¬μ—«∑’ˇ«≈“ ˆ.ÛÚ π“∑’ ·≈–§à“‡∫’ˬ߇∫π¡“μ√∞“π
‡∑à“°—∫ Ú.Ò π“∑’ μ“¡«‘∏’ Thai Pharmacopoeia 1997 °“√μ√«®«‘‡§√“–Àå§à“∑“ß™’«‡§¡’¢ÕßÕ“ “ ¡—§√∑—ÈßÀ¡¥

Volume II Part 1. À≈—ß°‘π “√ °—¥‰¥â Ú, Ù, ˆ, ¯ ·≈– ÒÚ —ª¥“Àå æ∫«à“§à“
º≈°“√μ√«®§ÿ≥¿“æ¢Õß·§ª´Ÿ≈ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß ∑“ß™’«‡§¡’∫“ß§à“‡ª≈’ˬπ·ª≈ßÕ¬à“ß¡’π—¬ ”§—≠ §◊Õ ALP ≈¥
Ù
‚¥¬ ∂“∫—π«‘®—¬ ¡ÿπ‰æ√ °√¡«‘∑¬“»“ μ√å°“√·æ∑¬å æ∫«à“ ≈ß„π —ª¥“Àå∑’Ë Ù ·≈– ¯ ‚ª√μ’π√«¡≈¥≈ß„π —ª¥“Àå∑’Ë Ù ·≈–
ºà“π‡°≥±å∑’Ë°”Àπ¥‰«â ”À√—∫«—μ∂ÿ¥‘∫ ·≈–μ√«®æ∫ genistein ÒÚ, ·Õ≈∫Ÿ¡‘π≈¥≈ß„π —ª¥“Àå∑’Ë Û, ˆ ·≈– ÒÚ, §√’Õ–∑‘π’π
7-0-[ γ -rhamnopyranosyl-(1→6)- γ -glucopyranoside]. ≈¥≈ßÀ≈—ß®“°°‘π “√ °—¥‰¥â Ò, Ù, ˆ ·≈– ¯ (μ“√“ß∑’Ë Ú).

®“°°“√μ√«®À“ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–‚¥¬«‘∏’°“√ lipid
ÚÛ ∑“ß«‘∑¬“¿Ÿ¡‘§ÿâ¡°—π
peroxidation (liposome) æ∫«à“·§ª´Ÿ≈ “√ °—¥‡∂“«—≈¬å
+ +
‡ª√’¬ß¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–‚¥¬¡’§à“‡©≈’ˬ IC ‡∑à“°—∫ (ˆ.ıÛ ‰¡àæ∫°“√‡ª≈’ˬπ·ª≈ߢÕß®”π«π‡´≈≈å CD3 , CD4
50
+
± .ıÒÙ ¡§°./¡≈. (∑”°“√∑¥ Õ∫‡æ◊ËÕÀ“§à“ IC Û §√—Èß ·≈– CD8 Õ¬à“ß¡’π—¬ ”§—≠μ≈Õ¥ ¯ —ª¥“Àå∑’Ë∑”°“√»÷°…“.
50
·μà≈–§√—È߉¥â§à“ IC ‡∑à“°—∫ ˜.ıÚ, ı.¯ˆ ·≈– ˆ.ÒÛ ¡§°./ °“√‡æ‘Ë¡®”π«π≈‘¡‚ø‰´μå ‡¡◊ËÕ∂Ÿ°°√–μÿâπ¥â«¬ PHA ∑’˧«“¡
50
¡≈.). ‡¢â¡¢âπ Ò ·≈– Ú ¡§°./¡≈. ·≈–°“√∑”ß“π¢Õ߇´≈≈å NK
·μ°μà“ßÕ¬à“ß¡’π—¬ ”§—≠„π —ª¥“Àå∑’Ë ˆ ·≈– —ª¥“Àå∑’Ë ÒÚ
∑“ß‚≈À‘μ«‘∑¬“
μ“¡≈”¥—∫ (μ“√“ß∑’Ë Û).

Õ“ “ ¡—§√∑—Èß Ù˜ √“¬‰¥â√—∫°“√μ√«®«‘‡§√“–Àå§à“∑“ß ª√‘¡“≥ “√À≈—Ëß®“°‡´≈≈å„π´’√—Ë¡∑’Ë»÷°…“§◊Õ IL-2, IL-4
‚≈À‘μ«‘∑¬“°àÕπ°‘π “√ °—¥‡∂“«—≈¬å‡ª√’¬ß·≈–À≈—ß°‘π “√ ·≈– γ-IFN π—Èπæ∫«à“ Õ“ “ ¡—§√∑—Èß Ù˜ √“¬μ√«®‰¡àæ∫ IL-
°—¥„π —ª¥“Àå∑’Ë Ú, Ù, ˆ, ¯ ·≈– ÒÚ æ∫«à“§à“∑“ß‚≈À‘μ 2 ·≈– IL-4 °àÕπ°‘π “√ °—¥ ·μàæ∫«à“ Ú √“¬¡’ª√‘¡“≥ IL-2

μ“√“ß∑’Ë Ò §à“‚≈À‘μ«‘∑¬“¢ÕßÕ“ “ ¡—§√∑’ˉ¥â√—∫ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß ¢π“¥ Ú ¡‘≈≈‘°√—¡μàÕ§√—Èß «—π≈– Ú §√—Èß ‡ªìπ‡«≈“ ¯ —ª¥“Àå

√–¬–‡«≈“À≈—ß°‘𬓇∂“«—≈¬å‡ª√’¬ß
§à“‚≈À‘μ«‘∑¬“
—ª¥“Àå∑’Ë  —ª¥“Àå∑’Ë Ú —ª¥“Àå∑’Ë Ù —ª¥“Àå∑’Ë ˆ —ª¥“Àå∑’Ë ¯ —ª¥“Àå∑’Ë ÒÚ

‡¡Á¥‡≈◊Õ¥¢“« (K/(L) ˆ.Ú˜± Ò.ˆ¯ ˆ.ˆÚ ± Ò.ıÛ ˆ.Ûı ± Ò.ˆ˘ ˆ.˜˘± Ò.˘Û ˆ.ıÒ ± Ò.˜Ù ˆ.ÛÛ ± Ò.ÙÒ
π‘«‚μ√øî≈ (%) ıÚ.ˆˆ± ˘.Û¯ ıÛ.ÛÛ ± ˘.˜˜ ıÒ.ÙÒ ± ˘.Ú ıÛ.˜ ± ˘.˘Ú ıÚ.˜Û ± ˘.ˆÒ ıÒ.ÒÛ ± ˘.¯Û
≈‘¡‚ø‰´μå (%) ÛÙ.˜Ú± ˜.˘Ú ÛÙ.Ùı± ˜.˘ı Ûı.˘Ú ± ˜.ıÙ ÛÛ.˘Ù± ˘.Ú ÛÙ.˘ ± ˜.˘Ù Ûˆ.Ò ± ˜.Ù
‚¡‚π‰´μå (%) ˜.Ò¯± Ú.ÒÒ ˆ.˘˜± Ò.ˆ˜ ˜.Û˘ ± Ú.ÛÒ ˜.˜Ò± Ú.Ò¯ ˜.ÒÙ ± Ò.˜Ú ˜.ÚÚ ± Ò.˜¯
Õ’‚Õ´‘‚πøî≈ (%) Ù.ıÒ± Ù.ÙÛ Ù.Ú˘ ± Ù.ÚÚ Ù.ÚÙ ± Ù.ÒÙ Ù.ÛÚ ± Ù.ı Ù.Ò¯ ± Ù.ıÛ Ù.ıÙ± Ù.ˆÒ
‡¡Á¥‡≈◊Õ¥·¥ß (x106/(L) ı.˘± .ˆˆ Ù.˘ˆ ± .ˆÙ* Ù.˘˜ ± .ˆı* Ù.˘ı± .ˆ* Ù.˘Ú± .ˆÚ* Ù.˘Û ± .ˆÒ*
Œ’‚¡‚°≈∫‘π (°./¥≈.) ÒÙ.Ú± Ò.Ùˆ ÒÛ.˜Ò ± Ò.ÛÚ ÒÛ.˜Û ± Ò.ÛÒ* ÒÛ.Ù¯± Ò.Ú¯* ÒÛ.Ù¯± Ò.Û˜* ÒÛ.Û˜ ± Ò.ÛÚ*
Œ’¡“‚μ§√‘μ (%) ÙÚ.Û¯± Ù.˜Ò ÙÒ.ÚÛ ± Ù.ÛÒ* ÙÒ.ÙÒ ± Ù.Ûı ÙÒ.¯ ± Û.˜ˆ* ÙÒ.Ò ± Ù.Ò˘* Ù.˜Û ± Û.¯¯*
‡°≈Á¥‡≈◊Õ¥ (K/(L) Ú˘Ò ±ˆ Û ± ˆÙ Ú˘˜ ±ıÛ Ú¯˜ ±ıı ÛÙ ±˜ Ú¯ı ±ıı

¢âÕ¡Ÿ≈∑ÿ°§à“· ¥ß„π√Ÿª §à“‡©≈’ˬ ±± ±± ± §à“‡∫’ˬ߇∫π¡“μ√∞“π
* ·μ°μà“ßÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘쑇¡◊ËÕ‡∑’¬∫°—∫°àÕπ‰¥â√—∫‡∂“«—≈¬å‡ª√’¬ß (§à“æ’<.ı)