Page 115 - วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 19 ฉบับที่ 2 พฤษภาคม-สิงหาคม 2564

J Thai Trad Alt Med Vol. 19 No. 2 May-Aug 2021 345

Efficacy and Safety of Ya Khiao-Hom Powder for the Treatment of Aphthous
Ulcer
Pattaraporn Chaihad , NattakittaPholor , Potchara Khamseetha , Subin Kongmuang ,
*
*,§
*
*
Krit Pongpirul , Methin Phadungkit
†
‡
Namphong Hospital, Namphong Sub-District, Namphong District, Khonkean 40310, Thailand
*
† Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Pathum Wan Sub-District,
Pathum Wan District, Bangkok 10330, Thailand
‡ Faculty of Pharmacy, Mahasarakham University, Kam Riang Sub-District, Kantharawichai District, Maha Sarakham
44150, Thailand
Corresponding author: k_pttm@hotmail.com
§
Abstract

Ya Khiao-Hom Powder (KHP) is a Thai traditional medicine preparation in the National List of Essential
Medicines. The remedy has been used to relieve fever as well as the symptoms of aphthous ulcer. This quasi-
experimental study aimed to evaluate the safety and efficacy of KHP for the treatment of aphthous ulcer and was
conducted in 100 patients of Namphong Hospital. The subjects were equally divided into two groups. The experi-
mental group received KHP 1 gram dissolved in 15 ml of warm water to be taken orally twice daily before meal in
the morning and evening as well as the application of KHP over the ulcers 4 times daily after meal and at bedtime,
while the subjects in the control group received 0.1% triamcinolone oral paste, apply as thin film cover the ulcers
3-4 times daily after meal and at bedtime. The sizes of the ulcers and pain scores were measured and recorded on
days 0, 2 and 6. Overall satisfaction of the treatment and side effects were also recorded. The results showed that
the mean ages of the experimental group and the control group were 53.1 years and 55.2 years, respectively. The
number of oral ulcers in each subject in both groups was 1–3. On day 0, the mean ulcer size at the 1 position in
st
the experimental group was significantly greater than that in the control group (p < 0.05), but those in the 2 and
nd
3 positions were not significantly different (p ≥ 0.05), while on day 2, the mean ulcer size at all positions in the
rd
experimental group greatly reduced but was not significantly different from that in the control group (p ≥ 0.05).
On day 6, all oral ulcers healed in all patients in the experimental group, while the healing rate in the control group
was 74.0%. On days 2 and 6, the mean pain score in the experimental group was significantly lower than that in
the control group (p < 0.05). In addition, no adverse effects were found. In conclusion, this study has shown that
KHP is effective for the treatment of aphthous ulcer without causing any side effect.

Key words: Ya Khiao-Hom powder, aphthous ulcer, efficacy, safety

บทนำ�และวัตถุประสงค์ บัญชียาหลักแห่งชาติ มีการตรวจสอบแหล่งผลิตยา

กรมการแพทย์แผนไทยและการแพทย์ทางเลือก จากสมุนไพรให้ผ่าน GMP เพื่อให้การบริการทางการ

กระทรวงสาธารณสุข มีนโยบายส่งเสริมการใช้ยาจาก แพทย์แผนไทยได้อย่างมีคุณภาพตามมาตรฐานและ
สมุนไพรทดแทนการใช้ยาแผนปัจจุบันในสถานบริการ ประชาชนมีความปลอดภัยในการใช้ยา มีการกำาหนด
สุขภาพของรัฐและสนับสนุนการใช้ยาจากสมุนไพรใน ตัวชี้วัดในการใช้ยาจากสมุนไพรในโรงพยาบาลทุก