Page 113 - journal-7-23-Full

P. 113

ÚÒˆ «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“ß‡≈◊Õ° ªï∑’Ë ˜©∫—∫∑’Ë Ú-Û æƒ…¿“§¡ - ∏—π«“§¡ ÚııÚ

°“√«‘‡§√“–Àå„πÀ≈Õ¥∑¥≈Õß‡∑à“π—Èπ∑’Ë “¡“√∂°√–μÿâπ¡¥≈Ÿ° ∑”„Àâƒ∑∏‘Ï¢Õß acetylcholine(Ach) „π°“√§≈“¬À≈Õ¥‡≈◊Õ¥

„πÀπŸ¬—ß‰¡à‚μ‡μÁ¡«—¬∑’Ë∂Ÿ°μ—¥√—ß‰¢à‰¥â. º≈°“√»÷°…“π’Èπ—∫‡ªìπ ´÷Ëß‡ªìπƒ∑∏‘Ï∑’ËμâÕßÕ“»—¬‡¬◊ËÕ∫ÿÀ≈Õ¥‡≈◊Õ¥ (endothelium-de-
À≈—°∞“π™‘Èπ·√°∑’Ë· ¥ßƒ∑∏‘Ï§≈â“¬‡Õ ‚μ√‡®π„π —μ«å∑¥≈Õß pendent relaxation) ‡æ‘Ë¡¢÷ÈπÕ¬à“ß¡“° ·μà “√ °—¥‡Œ°‡´π
¢Õß “√°≈ÿà¡‰¥·Õ√‘≈‡Œª∑“πÕ¬¥å®“°«à“π™—°¡¥≈Ÿ°. “√°≈ÿà¡ ‰¡à¡’º≈μàÕƒ∑∏‘Ï¢Õß sodium nitroprusside „π°“√∑”„Àâ

‰¥·Õ√‘≈‡Œª∑“πÕ¬¥å®÷ß‡ªìπ “√§≈â“¬ŒÕ√å‚¡π‡Õ ‚μ√‡®π®“° ∑àÕ‡≈◊Õ¥·¥ß„À≠à∑’Ë‰¡à¡’‡¬◊ËÕ∫ÿÀ≈Õ¥‡≈◊Õ¥§≈“¬μ—« ¥—ßπ—Èπ
∏√√¡™“μ‘°≈ÿà¡„À¡à ∑’Ë¡’»—°¬¿“æ„π°“√æ—≤π“‡ªìπº≈‘μ¿—≥±å ƒ∑∏‘Ï„π°“√§≈“¬À≈Õ¥‡≈◊Õ¥¢Õß “√ °—¥‡Œ°‡´π à«π„À≠à®÷ß
Õ“À“√‡ √‘¡‡æ◊ËÕ∫√√‡∑“Õ“°“√„°≈âÀ¡¥√–¥Ÿ„π μ√’«—¬∑Õß. ‡ªìπº≈μàÕ‡¬◊ËÕ∫ÿÀ≈Õ¥‡≈◊Õ¥¡“°°«à“º≈μàÕ°≈â“¡‡π◊ÈÕ‡√’¬∫¢Õß

À≈Õ¥‡≈◊Õ¥. ‡¡◊ËÕπ”∑àÕ‡≈◊Õ¥·¥ß„À≠à¡“ incubate °—∫ ICI
‰ø‚μ‡Õ ‚μ√‡®π®“°«à“π™—°¡¥≈Ÿ°‡æ‘Ë¡°“√§≈“¬μ—« 182,780 (estrogen receptor antagonist), L-NAME (ni-

À≈Õ¥‡≈◊Õ¥·¥ß¢ÕßÀπŸ·√μ tric oxide synthase inhibitor) À√◊Õ ODQ (guanylase
ÿ∑∏‘√“ Õ‘πμä–º—¥, Õ¿‘™“μ ÿ¢ ”√“≠, ¿“«‘≥’ ªî¬–®μÿ√«—≤πå cyclase inhibitor) ®–¬—∫¬—Èßƒ∑∏‘Ï¢Õß«à“π™—°¡¥≈Ÿ°„π°“√
¿“§«‘™“ √’√«‘∑¬“ §≥–«‘∑¬“»“ μ√å ¡À“«‘∑¬“≈—¬¡À‘¥≈ ‡ √‘¡ƒ∑∏‘Ï§≈“¬À≈Õ¥‡≈◊Õ¥¢Õß Ach · ¥ß«à“«à“π™—°¡¥≈Ÿ°

°√ÿß‡∑æœ ÕÕ°ƒ∑∏‘Ïºà“π estrogen receptor (ER) ·≈–°≈‰°∑’Ë¢÷Èπ°—∫
Vascul Pharmacol 2009;51:284-90. ‰πμ√‘°ÕÕ°‰´¥å ·≈– cGMP (NO-cGMP-dependent

«—μ∂ÿª√– ß§å¢Õß°“√»÷°…“π’È‡æ◊ËÕ∑¥ Õ∫∂÷ßª√– ‘∑∏‘º≈ mechanisms). πÕ°®“°π’È «à“π™—°¡¥≈Ÿ°¬—ß‡æ‘Ë¡°“√‡μ‘¡À¡Ÿà
·≈–°≈‰°°“√ÕÕ°ƒ∑∏‘Ï¢Õß«à“π™—°¡¥≈Ÿ° (Curcuma comosa øÕ ‡øμ (phosphorylation) ·°à serine 1177 eNOS ·≈–
Roxb.) ´÷Ëß‡ªìπ ¡ÿπ‰æ√æ◊Èπ∫â“π∑’Ë¡’‰ø‚μ‡Õ ‚μ√‡®πƒ∑∏‘Ï serine 473 Akt proteins ‚¥¬ ICI 182,780 “¡“√∂¬—∫¬—Èß

§≈“¬μ—«À≈Õ¥‡≈◊Õ¥. ‡¡◊ËÕ‡μ‘¡ “√ °—¥¥â«¬‡Œ°‡´πÀ√◊Õ “√ D3 °√–∫«π°“√π’È · ¥ß«à“«à“π™—°¡¥≈Ÿ°‡æ‘Ë¡°“√§≈“¬∑àÕ‡≈◊Õ¥
´÷Ëß‡ªìπ “√°≈ÿà¡‰¥·Õ√‘≈‡Œª∑“πÕ¬¥å®“°«à“π™—°¡¥≈Ÿ°≈ß„π ·¥ß„À≠à·∫∫Õ“»—¬‡¬◊ËÕ∫ÿÀ≈Õ¥‡≈◊Õ¥Õ¬à“ß‡©’¬∫æ≈—π ‚¥¬ºà“π
organ bath ∑’Ë¡’«ß·À«π∑àÕ‡≈◊Õ¥·¥ß„À≠à ∑—Èß·∫∫∑’Ë¡’·≈– ERK-Akt-eNOS pathway. º≈°“√»÷°…“π’È‡ªìπÀ≈—°∞“π™‘Èπ

‰¡à¡’‡¬◊ËÕ∫ÿÀ≈Õ¥‡≈◊Õ¥ æ∫«à“‰¡à¡’º≈§≈“¬À≈Õ¥‡≈◊Õ¥. Õ¬à“ß‰√ ·√°∑’Ë√–∫ÿ∂÷ß°“√ÕÕ°ƒ∑∏‘Ï∑’Ë‰¡àºà“π®’‚π¡ (non-genomic ac-
°Áμ“¡ ‡¡◊ËÕ incubate ∑àÕ‡≈◊Õ¥·¥ß„À≠à„π “√ °—¥‡Œ°‡´π tion) ¢Õß‰ø‚μ‡Õ ‚μ√‡®π°≈ÿà¡„À¡à®“°«à“π™—°¡¥≈Ÿ°μàÕ°“√
¢Õß«à“π™—°¡¥≈Ÿ° (Ò ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√) À√◊Õ “√ D3 (.Ò, §≈“¬μ—«¢ÕßÀ≈Õ¥‡≈◊Õ¥.

Ò ·≈– Ò ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√) ‡ªìπ‡«≈“ Ú π“∑’ ®–

108 109 110 111 112 113 114 115 116 117 118