Page 63 - journal-7-1-Full

Journal of Thai Traditional & Alternative Medicine Vol. 7 No. 1 January-April 2009 ıı

5,7,4'- trihydroxy-6,3-diprenylisoflavone, erysenegalensein ‡¡◊ËÕ»÷°…“§«“¡‡ªìπæ‘…‡©’¬∫æ≈—π¢Õß “√ °—¥¥â«¬

E, derrisisoflavones A-F, scandinone, lupiniisoflavone ‡Õ∏“πÕ≈ ı% ¢Õ߇∂“«—≈¬å‡ª√’¬ßæ∫«à“¢π“¥∑’ˇªìπæ‘…∑”„Àâ
G, lupalbigenin, derrisscandenosides A-E, 7,8- ÀπŸμ“¬√âÕ¬≈– ı §◊Õ Ò °./°°. ·μà‡¡◊ËÕ„Àâ‚¥¬°“√ªÑÕπ∑“ß
dihydroxy-4'-methoxyisoflavone, formononetin-7-0-β- ª“°À√◊Õ©’¥„μâÀπ—ß„π¢π“¥ Ò °./°°. π—Èπ‰¡àæ∫§«“¡‡ªìπ
Ú
glucopyranoside, 8-hydroxy-4',7-dimethoxyisoflavone- æ‘…„¥ Ê μàÕ —μ«å∑¥≈Õß ·≈–º≈°“√∑¥ Õ∫æ‘…‡√◊ÈÕ√—ß‚¥¬
8-0-β-glucopyranoside, 7-hydroxy-4',8-dimethoxyisoflavone- ªÑÕπ “√ °—¥„ÀâÀπŸ¢“«„π¢π“¥ Ÿß∂÷ß ˆ ¡°./°°/«—πÀ√◊Õ
7-7-β-glucopyranoside, diadzein-7-0-[α-rhamnopyranosyl- ¢π“¥ ˜ı-Ò ‡∑à“¢Õߢπ“¥∑’Ë„™â„π§πμàÕ«—𠇪ìπ‡«≈“ ˆ

(1→6)]-β-glucopyranoside, derrisscanosides A-B, ‡¥◊Õππ—Èπ ‰¡àæ∫Õ“°“√∑’Ë· ¥ß∂÷ߧ«“¡‡ªìπæ‘…μàÕÕ«—¬«–·≈–
ÚÒ
genistein-7-0-[α-rhamnopyranosyl-(1→6)]-β-gluco- °“√∑”ß“π¢Õß√–∫∫μà“ß Ê ¢ÕßÀπŸ¢“« .
pyranoside, 3-aryl-4-hydroxycoumarins, 4-hydroxy-3- §≥–ºŸâ«‘®—¬¢Õß ∂“∫—π«‘®—¬ ¡ÿπ‰æ√‰¥â∑”°“√»÷°…“§«“¡
methoxybenzoic acid, 4-hydroxy-3-dimethoxybenzoic ª≈Õ¥¿—¬¢Õß “√ °—¥‡∂“«—≈¬å‡ª√’¬ß√–¬–∑’Ë Ò „πÕ“ “ ¡—§√
acid ·≈–æ∫ “√ª√–‡¿∑ ‡μÕ√Õ¬¥å®“° à«π‡Àπ◊Õ¥‘π¢Õß ª√°μ‘ ‚¥¬‰¥â√—∫Õπÿ¡—μ‘®“°§≥–°√√¡°“√æ‘®“√≥“°“√»÷°…“
ÒÙ
‡∂“«—≈¬å‡ª√’¬ß ‡™àπ lupeol, taraxerol ·≈– β-sitosterol . «‘®—¬„π§π °√–∑√«ß “∏“√≥ ÿ¢ ∑’Ë ∏ ÛÛÛ/ı˜ıÚ ≈ß«—π
“√ °—¥≈”μâπ¢Õ߇∂“«—≈¬å‡ª√’¬ß¥â«¬πÈ”¡’ƒ∑∏‘Ïμâ“π°“√ ∑’Ë Ù ∏—𫓧¡ ÚıÙÛ. „π°“√»÷°…“√–¬–∑’Ë Ò π’È¥”‡π‘π°“√

Õ—°‡ ∫ ‚¥¬≈¥°“√À≈—Ëß myeloperoxide ≈¥°“√ √â“ß ∑¥≈Õß„πÕ“ “ ¡—§√ ÒÚ √“¬ ‡ªì𙓬 ˆ √“¬ ·≈–À≠‘ß ˆ
eicosanoid ·≈–¡’ƒ∑∏‘Ϭ—∫¬—Èß leukotriene B4 ´÷Ë߇ªìπ “√∑’Ë √“¬, Õ“¬ÿ ÚÒ-ÙÙ ªï. Õ“ “ ¡—§√∑—ÈßÀ¡¥‰¥âºà“π‡°≥±å°“√
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°àÕ„À⇰‘¥°“√Õ—°‡ ∫ ´÷Ëß¡’º≈∑”„À⇰‘¥°“√ª«¥‡¡◊ËÕ¬ . ƒ∑∏‘Ï≈¥ §—¥‡≈◊Õ°¢Õß‚§√ß°“√¬‘π¬Õ¡≈ßπ“¡‡¢â“√à«¡‚¥¬ ¡—§√„®®π
°“√Õ—°‡ ∫∑’ËÕÿâ߇∑â“ÀπŸæ∫«à“‰¥âº≈¥’Õ¬à“ß¡’π—¬ ”§—≠‡¡◊ËÕ„™â §√∫°”Àπ¥. Õ“ “ ¡—§√∑—Èß ÒÚ √“¬ ‰¥â√—∫·§ª´Ÿ≈‡∂“«—≈¬å
‡ªì𬓩’¥„μâÀπ—ß ·μà‰¡à¡’ƒ∑∏‘χ¡◊ËÕªÑÕπ∑“ߪ“°. πÕ°®“°π’È ‡ª√’¬ß§√—Èß≈– Ò ·§ª´Ÿ≈ (Ú ¡°./·§ª´Ÿ≈) À≈—ßÕ“À“√ «—π
Òı
æ∫«à“ “√ °—¥πÈ”¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–¥â«¬ „π¢≥–∑’Ë “√ ≈– Ú §√—Èß π“π Ú ‡¥◊Õπ. ®“°°“√»÷°…“‰¡àæ∫§«“¡‡ªìπæ‘…
Òˆ
°—¥¥â«¬∫‘«∑“πÕ≈¡’ƒ∑∏‘Ï≈¥·√ߥ—π‡≈◊Õ¥‰¥â ·≈–¬—ß¡’√“¬ß“π „¥ Ê „πÕ“ “ ¡—§√∑’ˉ¥â√—∫ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß ·≈–æ∫«à“
ÚÚ
Õ’°¥â«¬«à“ 5,7,4'-trihydroxy-6,3'-diprenylisoflavone ∑’Ë ¡’·π«‚π⡇ √‘¡°“√∑”ß“π¢Õß√–∫∫¿Ÿ¡‘§ÿâ¡°—π¢Õß√à“ß°“¬
·¬°‰¥â®“° “√ °—¥‡Õ∏“πÕ≈¡’ƒ∑∏‘Ïμâ“π‡™◊ÈÕ√“ Trichophyton ‚§√ß°“√π’ȇªìπ°“√»÷°…“«‘®—¬„π§π√–¬–∑’Ë Ú ‡æ◊ËÕ»÷°…“
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mentagrophytes ª√– ‘∑∏‘º≈∑’Ë™—¥‡®π¢Õß “√ °—¥‡∂“«—≈¬å‡ª√’¬ß„πÕ“ “ ¡—§√
“√ °—¥¥â«¬‡Õ∏“πÕ≈ ı% ®“°≈”μâπ¢Õ߇∂“«—≈¬å Ù˜ √“¬ ‚¥¬°”À𥇰≥±å°“√§—¥‡≈◊Õ°Õ“ “ ¡—§√‡¢â“√à«¡

‡ª√’¬ß “¡“√∂°√–μÿâπ°“√·∫àßμ—«¢Õß≈‘¡‚ø‰´μå¢ÕßÀπŸ∂’∫®—°√ ‚§√ß°“√·≈–‡°≥±å°“√‡≈‘°°“√‡¢â“√à«¡‚§√ß°“√Õ¬à“ß™—¥‡®π.
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·≈–°√–μÿâπ°“√À≈—ËßÕ‘π‡μÕ√å≈‘«§‘π-Ú ‰¥â ·≈–‡¡◊ËÕ∑¥ Õ∫‚¥¬ ¡’°“√ —¡¿“…≥å μ√«®√à“ß°“¬ ·≈–μ√«®∑“ßÀâÕߪؑ∫—μ‘°“√∑ÿ°
„™â‡´≈≈å‚¡‚π𑫇§≈’¬√å ®“°°√–· ‡≈◊Õ¥¢Õߧπ ÿ¢¿“æª√°μ‘ Ú —ª¥“Àå ‡æ◊ËÕ¥Ÿ°“√‡ª≈’ˬπ·ª≈ß∑“ß‚≈À‘μ«‘∑¬“, ∑“ß™’«‡§¡’

æ∫«à“™à«¬‡æ‘Ë¡°“√·∫àßμ—«¢Õß≈‘¡‚ø‰´μåÕ¬à“ß¡’π—¬ ”§—≠∑’Ë ¢Õß´’√—Ë¡ ·≈–μàÕ√–∫∫¿Ÿ¡‘§ÿâ¡°—π ‚¥¬Õ“ “ ¡—§√∑’ˇ¢â“√à«¡
§«“¡‡¢â¡¢âπμ—Èß·μà Ò π°./¡≈. ∂÷ß ı ¡§°./¡≈. ·≈–™à«¬ ‚§√ß°“√¥â«¬§«“¡ ¡—§√„®·≈–≈ßπ“¡„π„∫¬‘π¬Õ¡®–‰¥â°‘π

‡æ‘Ë¡°“√∑”ß“π¢Õß NK cells Õ¬à“ß¡’π—¬ ”§—≠∑’˧«“¡‡¢â¡¢âπ ·§ª´Ÿ≈‡∂“«—≈¬å‡ª√’¬ß§√—Èß≈– Ò ·§ª´Ÿ≈ (Ú ¡°./·§ª´Ÿ≈)
μ—Èß·μà Ò π°./¡≈. ∂÷ß Ò ¡§°./¡≈. ·≈–¬—ßæ∫ª√‘¡“≥Õ‘π À≈—ßÕ“À“√ «—π≈– Ú §√—Èß π“π Ú ‡¥◊Õπ ‡æ◊ËÕª√–‡¡‘π
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‡μÕ√å≈‘«§‘π-Ú ‡æ‘Ë¡¢÷ÈπÕ’°¥â«¬ · ¥ß«à“ “√ °—¥‡∂“«—≈¬å‡ª√’¬ß ª√– ‘∑∏‘º≈„π°“√™à«¬‡æ‘Ë¡¿Ÿ¡‘§ÿâ¡°—π¢Õß√à“ß°“¬ ´÷ËßÕ“®π”‰ª
“¡“√∂‡ √‘¡°“√∑”ß“π¢Õß√–∫∫¿Ÿ¡‘§ÿâ¡°—π·∫∫Õ“»—¬‡´≈≈å Ÿà°“√»÷°…“‡æ◊ËÕª√–¬ÿ°μå„™â„πºŸâ∑’Ë¡’¿Ÿ¡‘§ÿâ¡°—π∫°æ√àÕßμàÕ‰ª.
¢Õߧπª√°μ‘„πÀ≈Õ¥∑¥≈Õ߉¥â ·≈–¬—ßæ∫Õ’°«à“ “√ °—¥∑’Ë °“√»÷°…“π’ȉ¥âºà“π°“√Õπÿ¡—μ‘®“°§≥–°√√¡°“√
§«“¡‡¢â¡¢âπ Ò ¡§°./¡≈. “¡“√∂‡æ‘Ë¡°“√∑”ß“π¢Õß NK æ‘®“√≥“°“√»÷°…“«‘®—¬„π§π °√–∑√«ß “∏“√≥ ÿ¢ μ“¡
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cells ¢ÕߺŸâμ‘¥‡™◊ÈÕ‡Õ™‰Õ«’ ‰¥âÕ’°¥â«¬ Àπ—ß ◊Õ∑’Ë ∏ ÛÚÒ/˘˘˜ ≈ß«—π∑’Ë Ò¯ ¡’π“§¡ ÚıÙˆ.