Page 122 - วารสารการแพทย์แผนไทย ปีที่ 21 ฉบับที่ 2

338 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 2 พฤษภาคม-สิงหาคม 2566

Discussion ditional TakKaSila pharmacopoeia to be the
Ya Prasa PraoYai, Ya Ha Rak and Ya first-line drug formulation to treat flu according

Chanthalila drug formulations which are tradi- and was also recommended to alleviate symp-
tionally used to treat flu due to their antipyretic toms during the Covid-19 infection. In contrast
properties were screened for anti-SARS-CoV-2 Ya Chanthalila has been effectively used dur-

activity. The aqueous extract of PSP, CTL and ing the recovery period following Covid-19
[22]
Y5R are reported here for the first time to pose infection. Testing of the Anti-viral properties
anti- SARS-CoV-2 activity. The three prepa- of the three preparations at 5 mg/mL did not re-
rations used in this study are similar to the veal significant differences. The main plant in
types of preparations used in Thai traditional the Ya Prasa Pro Yai preparationwas K. galanga

medicine which are made of various medici- L. which has been used to treat measles and
[21]
nal plants. K. galanga L. which is the main herpes simplex virus infection. Ya Ha Rak
[11]
component in PSP, is now reported to include preparation consisted of five herbal roots in
phytochemchemicals such as terpenoids, phe- the same proportion. Some sources reported
nolics, cyclic dipeptides, diarylheptanoids, fla- that chlorophyll derivatives and quercetin in

[21]
vonoids, polysaccharides, and essential oils. T. triandra (Colebr.) Diels) could be potential
These phytochemicals were mostly presented therapeutic agents for treating COVID-19. [23]
in blue and yellow to anisaldehyde sulphuric Meanwhile, Ya Chanthalila is made of different

acid reagent in contrast to Y5R and CTL which plants, some of which are used in Chinese tra-
mostly presented yellow spots indicating the ditional medicine and reported to be promising
presence of different phytochemicals. for SARS-CoV-2 treatment. A. lancea (Thunb)

Ya Prasa Pro Yai preparation is normally DC.) has been found using molecular docking
used to treat gastrointestinal tract symptoms, analysis to lower binding energy with key

e.g., stomach pain, flatulence and anorexia [18] proteins, suppresse cytokine storm and regu-
[24]
because the main herbal component is K. late some anti-viral pathways. A. vulgaris L.
galanga L. or PraoHom in Thai. PraoHom is has also been reported to demonstrate in vitro

also found to be one of the main components in inhibition of FCoV or SARS-CoV-2 virus. [16]
the YaKheawHom preparation, which is used D. loureiroi Gagnep. and T. hoaensis Pit., the

[18]
to treat measles and herpes simplex virus. mixed ingredients in Kerra formulation have
Ya Ha Rak formulation or the five roots drug been found to inhibit the SARS-CoV-2 main
formulation, is recommended by the Thai tra- protease and SARS-CoV-2 RdRp with IC 50