Page 119 - วารสารการแพทย์แผนไทย ปีที่ 21 ฉบับที่ 2

J Thai Trad Alt Med Vol. 21 No. 2 May-Aug 2023 335

The ability of the different formulations to compared with the virus controls. The CTL
reduce the pre-entry phase of the SARS-CoV-2 showed the highest plaque reduction of 50.11%

virus was evaluated. Vero E6 cells were used while PSP and Y5R gave the lower percentage
as host cells for the virus. The drugs were of the plaque reduction of 45.60%. The anti-
evaluated at a concentration of 5.00 mg/mL, viral activity of the three drug formulations is

which was not toxic to the cells. The percent- shown in Table 1.
age of the plaque reduction was calculated

Table 1 Anti-viral activities of Ya Prasa Pro Yai (PSP), Ya Ha Rak (Y5R), Ya Chanthalila (CTL). The data were
expressed as the mean, n = 2.

Herbal extracts/compounds The concentration tested (mg/mL) % Plaque reduction
PSP 5.00 45.60
Y5R 5.00 45.60
CTL 5.00 50.11

Figure 2 Cytotoxicity of CTL, PSP and Y5R to calu-3 cell line. The concentrations were calculated from the
non-linear regression as the inhibitory concentration (IC) at 50% (IC 50), 20% (IC 20) and 10% (IC 10).