Page 251 - วารสารการแพทย์แผนไทยฯ ปีที่ 19 ฉบับที่ 1

J Thai Trad Alt Med Vol. 19 No. 1 Jan-Apr 2021 233

isolated from Andrographis paniculata in animal models. Acanthaceae) against the primary dengue vector Aedes
Biol Res Nurs. 2010;11(3):293-301. aegypti (Diptera: Culicidae). Acta Trop. 2016;163:167-78.
16. Madav S, Tripathi HC, Tandan MSK. Analgesic, anti- 26. Gupta B, Mishra KP, Ganju L. 2017. Broad-spectrum
pyretic and antiulcerogenic effects of andrographolide. antiviral properties of andrographolide. Arch Virol.
Indian J Pharm Sci. 1995;57(3):121-5. 2017;162(3): 611-23.
17. Nosálová G, Majee SK, Ghosh K, Raja W, Chatter- 27. Caceres DD, Hancke JL, Burgos RA, Wikman GK. Pre-
jee UR, Jureček L, Ray B. Antitussive arabinoga- vention of common colds with Andrographis paniculata
lactan of Andrographis paniculata demonstrates dried extract. A pilot double blind trial. Phytomedicine.
synergistic effect with andrographolide. Int J Biol 1997;4(2):101-4.
Macromol. 2014;69:151-7. 28. Hancke J, Burgos R, Caceres D, Wikman G. A double-
18. Rajagopal S, Ajaya Kumar R, Deevi DS, Satyanarayana blind study with a new monodrug Kan Jang: decrease
C, Rajagopalan R. Andrographolide, a potential cancer of symptoms and improvement in the recovery from
therapeutic agent isolated from Andrographis paniculata. common colds. Phytother Res. 1995;9:559-62.
J Exp Ther Oncol. 2003;3:147-58. 29. Saxena RC, Singh R, Kumar P, Yadav SC, Negi MPS,
19. Xu Y, Chen A, Fry S, Barrow RA, Marshall RL, Mukkur Saxena VS, Amit A. A randomized double blind placebo
TKS. Modulation of immune response in mice immunized controlled clinical evaluation of extract of Andrographis
with an inactivated Salmonella vaccine and gavaged with paniculata (KalmCold™) in patients with uncompli-
Andrographis paniculata extract or andrographolide. Int cated upper respiratory tract infection. Phytomedicine.
Immunopharmacol. 2007;7:515-23. 2010;17(3-4):178-85
20. Cai W, Li Y, Chen S, Wang M, Zhang A, Zhou H, Chen 30. Bhuiyam FR, Howlader S, Raihan T, Hasan M. Plants me-
H, Jin M. 14-Deoxy-11,12-dehydroandrographolide tabolites: Possibility of natural therapeutics against the
exerts anti-influenza A virus activity and inhibits COVID-19 pandemic. Front Med (Lausanne). 2020;7:444.
replication of H5N1 virus by restraining nuclear export 31. Enmozhi SK, Raja K, Sebastine I, Joseph J. Androgra-
of viral ribonucleoprotein complexes. Antiviral Res. pholide as a potential inhibitor of SARS-CoV-2 main
2015;118:82-92. protease: An in silico approach. J Biomolec Struc Dyn.
21. Cai W, Chen S, Li Y, Zhang A, Zhou H, Chen H, Jin M. 2020. (DOI: 10.1080/07391102.2020.1760136)
14-Deoxy-11,12-didehydroandrographolide attenuates 32. Mohammad T, Shamsi A, Anwar S, Umair M, Hus-
excessive inflammatory responses and protects mice sain A, Rehman MT, AlAjmi MF, Islam A, Hassan MI.
lethally challenged with highly pathogenic A(H5N1) Identification of high-affinity inhibitors of SARS-CoV-2
influenza viruses. Antiviral Res. 2016;133:95-105. main protease: Towards the development of effective
22. Chen JX, Xue HJ, Ye WC, Fang BH, Liu YH, Yuan SH, COVID-19 therapy. Virus Res. 2020;288:198102.
Yu P, Wang YQ. Activity of andrographolide and its 33. Shi TZ, Huang YL, Chen CC, Pi WC, Hsu YL, Lo LC, Chen
derivatives against influenza virus in vivo and in vitro. WY, Fu SL, Lin CH. Andrographolide and its fluorescent
Biol Pharm Bull. 2009;32(8):1385-91. derivative inhibit the main proteases of 2019-nCoV and
23. Churiyah, Pongtuluran OB, Rofaani E, Tarwadi. Anti- SARS-CoV through covalent linkage. Biochem Biophys
viral and immunostimulant activities of Andrographis Res Commun. 2020;533(3):67–473.
paniculata. HAYATI J Biosci. 2015;22(2):67-72. 34. Maurya VK, Kumar S, Prasad AK, Bhatt MLB, Saxena SK.
24. Ding Y, Chen L, Wu W, Yang J, Yang Z, Liu S. Androgra- Structure-based drug designing for potential antiviral
pholide inhibits influenza A virus-induced inflamma- activity of selected natural products from Ayurveda
tion in a murine model through NF-kB and JAK-STAT against SARS-CoV-2 spike glycoprotein and its cellular
signaling pathway. Microbes Infect. 2017;19(12):605-15. receptor. VirusDisease. 2020;31:179-93.
25. Edwin ES, Vasantha-Srinivasan P, Senthil-Nathan S, 35. Murugan NA, Pandian CJ, Jeyakanthan J. Computational
Thanigaivel A, Ponsankar A, Pradeepa V, Selin-Rani S, investigation on Andrographis paniculata phytochemicals
Kalaivani K, Hunter WB, Abdel-Megeed A, Duraipandi- to evaluate their potency against SARS-CoV-2 in compari-
yan V, Al-Dhabi NA. Anti-dengue efficacy of bioactive son to known antiviral compounds in drug trials. J Biomol
andrographolide from Andrographis paniculata (Lamiales: Struct Dyn. 2020. (DOI: 10.1080/07391102.2020.1777901)