Page 79 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 1

Journal of Thai Traditional & Alternative Medicine Vol. 11 No. 1 January-April 2013 73

Lam (Õ‘π‡¥’¬) Aristolochia trilobata L. (Õ‡¡√‘°“ ‡ªìπ‡«≈“ 21 «—π°àÕπ‡®“–‡≈◊Õ¥μ√«®§à“‡§¡’§≈‘π‘°

°≈“ß Õ‡¡√‘°“„μâ·≈–·§√‘∫‡∫’¬π) Aristolochia º≈°“√»÷°…“‰¡àæ∫§«“¡º‘¥ª°μ‘¢Õß°“√∑”ß“π¢Õß
2
clematitis L. (¬ÿ‚√ª) ·≈– Aristolochia ‰μ„π∑ÿ°°≈ÿà¡ Õ¬à“߉√°Áμ“¡ À“°∑”°“√»÷°…“„π
1
bracteolata Lam. (·Õø√‘°“) πÕ°®“° ªï™’Ë å∑’Ë √–¬–¬“« º≈°“√»÷°…“Õ“®®–μà“߉ª®“°π’ȉ¥â
·μ°μà“ß°—π·≈â« à«π∑’Ëμà“ß°—π¢Õßæ◊™¬—ß„Àâº≈μàÕ ·¡â®–¡’¢âÕ¡Ÿ≈°“√»÷°…“«‘®—¬¢Õ߉§√⇧√◊ÕÕ¬Ÿà∫â“ß
√à“ß°“¬μà“ß°—π «‘∏’°“√∑”‡ªì𬓠‡™àπ ∫¥ ¡ÿπ‰æ√ ·μà°“√„™â¬“ ¡ÿπ‰æ√μ”√—∫¡’√“¬≈–‡Õ’¬¥·≈–§«“¡
‡ªìπºß∫√√®ÿ·§ª´Ÿ≈ μâ¡ ¡ÿπ‰æ√·≈â«¥◊Ë¡·μàπÈ” ´—∫´âÕπ´÷Ë߬—ßμâÕß°“√°“√»÷°…“‡æ‘Ë¡‡μ‘¡Õ’°¡“° ¥—ßπ—Èπ

°—¥ “√„π ¡ÿπ‰æ√¥â«¬μ—«∑”≈–≈“¬∑’Ëμà“ß°—π À√◊Õ °“√ª√–°“»„Àâμ—¥‰§√⇧√◊ÕÕÕ°®“° à«πª√–°Õ∫
„™â‡ªìπ à«πª√–°Õ∫¢Õß ¡ÿπ‰æ√μ”√—∫ °Á„Àâº≈∑’Ë μ”√—∫¬“ ¡ÿπ‰æ√∑’Ë¡’„™â°—π¡“π“π ·≈–„Àâ„™âμ”√—∫

·μ°μà“ß°—π‰ª πÕ°®“°π’È ª√‘¡“≥¢Õ߬“∑’ˉ¥â√—∫ ¥—ß°≈à“«‚¥¬∑’ˉ¡à¡’‰§√⇧√◊ÕÕ¬Ÿàπ—Èπ ∑“߇¿ —™°√√¡
·≈–√–¬–‡«≈“°“√„™â¬“ ≈â«π‡ªìπªí®®—¬∑’Ë¡’º≈μàÕ ∂◊Õ«à“μ”√—∫¥—ß°≈à“«®–°≈“¬‡ªìπμ”√—∫¬“„À¡à∑’ˬ—ß
ª√– ‘∑∏‘º≈·≈–°“√‡°‘¥æ‘…¢Õ߬“∑—Èß ‘Èπ ‰¡à¡’¢âÕ¡Ÿ≈°“√„™â„πÕ¥’μ ®÷ߧ«√¡’°“√»÷°…“∑—Èߥâ“π

¿“§«‘™“‡¿ —™«‘∑¬“ ·≈– ∂“π°“√·æ∑¬å·ºπ §ÿ≥¿“æ ª√– ‘∑∏‘º≈·≈–§«“¡‡ªìπæ‘…¢Õßμ”√—∫
‰∑¬ª√–¬ÿ°μå §≥–·æ∑¬»“ μ√廑√‘√“™æ¬“∫“≈ ‰¥â ¬“„À¡à‡À≈à“π’È°àÕπ„™â À√◊ÕÀ“°¡’§«“¡®”‡ªìπμâÕß„™â

«‘®—¬æ∫«à“ „πºß¬“®“°√“°·ÀâߢÕ߉§√⇧√◊Õ ªï™’Ë å §«√„™â¿“¬„μâ°“√§«∫§ÿ¡¢Õß·æ∑¬å·ºπ‰∑¬∑’Ë
Aristolochia tagala cham. 100 °√—¡π—Èπ ¡’ª√‘¡“≥ ‡™’ˬ«™“≠∑“ߥâ“π‡¿ —™°√√¡ ·≈–¡’°“√μ‘¥μ“¡
“√ aristolochic acid Õ¬Ÿà‡æ’¬ß 0.24 °√—¡‡∑à“π—Èπ ª√–‡¡‘πª√– ‘∑∏‘º≈·≈–§«“¡ª≈Õ¥¿—¬ Õ¬à“ß

·≈–‡¡◊ËÕμ√«®À“ “√„πμ”√—∫¬“ÀÕ¡π«‚°∞‡¥‘¡ (¡’ „°≈♑¥μàÕ‰ª
‰§√⇧√◊Õ‡ªìπ à«πª√–°Õ∫) °≈—∫‰¡àæ∫ aristolochic
acid ∑—Èßπ’È —ππ‘…∞“π«à“Õ“®¡’ “‡Àμÿ®“°°“√∑’Ë

aistolochic acid ®—∫μ—«°—∫ à«πª√–°Õ∫Õ◊Ëπ„π ‡Õ° “√Õâ“ßÕ‘ß
μ”√—∫®π‰¡à “¡“√∂μ√«®·¬° aristolochic acid ‰¥â 1. Heinrich M, Chan J, Wanke S, Neinhuis C, Simmonds
MS. Local uses of Aristolochia species and content of
À√◊ÕÕ“®∑”ªØ‘°‘√‘¬“°—∫ à«πª√–°Õ∫Õ◊Ëπ„πμ”√—∫·≈–
nephrotoxic aristolochic acid 1 and 2-a global assessment
‡ª≈’ˬπ·ª≈߉ª‡ªìπ “√Õ◊Ëπ ®÷ßμ√«®‰¡àæ∫ based on bibliographic sources. J Ethnopharmacol
2009;125(1):108-44.
aristolochic acid „πμ”√—∫¬“ à«π¥â“𧫓¡‡ªìπ
2. Tripatara P, Onlamul W, Booranasubkajorn S, Wat-
æ‘…π—Èπ ‰¥â¡’°“√»÷°…“«‘®—¬„πÀπŸ¢“« ‚¥¬°√Õ° ¡ÿπ tanarangsan J, Huabprasert S, Lumlerdkij N, et al. The
safety of Homnawakod herbal formula containing
‰æ√‰§√⇧√◊Õ‡¥’ˬ«À√◊Õ°√Õ°μ”√—∫¬“ÀÕ¡π«‚°∞∑’Ë¡’
Aristolochia tagala Cham. in Wistar rats. BMC Complement
·≈–‰¡à¡’‰§√⇧√◊Õ „π¢π“¥∑’ˇ∑’¬∫‡∑à“°—∫∑’Ë„™â„π§π Altern Med 2012;12:170.