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506 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 19 ฉบับที่ 2 พฤษภาคม-สิงหาคม 2564

The formulation 1 after 180 days storage components in the extract and stabilize the
at ambient condition, the total flavonoid con- cream base in long-term storage conditions.

tent is not detectable, while the formulation
2, the total flavonoids content slightly lower. Discussion
However, its total flavonoids content is still According to the recent Thai National

within the specification limit. The steep reduc- List of Essential Medicines (NLEM), Prayayor
tion of the total flavonoid content in formula- cream has still recommended to use the etha-
[14]
tion 1 is expected from the rapid hydrolysis of nolic extract without any modification . Even
the flavonoid exposed directly to the aqueous though the registration process also follows
part of the nonhomogeneous cream (Formula- the Thai National List of Essential Medicines
tion 1). (NLEM), The Prayayor cream’s failure ac-

According to the stability study the cordingly (see Figure 1a). According to this
proposed solution to resolve this problem is study, it is strongly recommended to revise the

to add a suitable solubilizer in the ethanolic Thailand National List of Essential Medicines
plant extract before incorporate the ethanolic (NLEM) to improve the stability of the Prayayor
plant extract into a cream base. This technique cream.

will prevent the decomposition of the active The study is only an exemplar to re-

(a) (b)

Figure 1 (a) 4% primary Clinacanthus nutans ethanolic extracts cream (Formulation 1) and (b) 4% secondary
Clinacanthus nutans ethanolic extract cream (Formulation 2). Obviously, the 4% secondary Clina-
canthus nutans ethanolic extract cream (Formulation 2) is bright greenish homogenous cream (b)
while 4% primary Clinacanthus nutans ethanolic extract cream (Formulation 1) is pale dull greenish
nonhomogeneous cream (a).