Page 53 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 3

P. 53

262 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“ß‡≈◊Õ° ªï∑’Ë 11 ©∫—∫∑’Ë 3°—π¬“¬π-∏—π«“§¡ 2556

μ“√“ß∑’Ë 8 ƒ∑∏‘Ï¬—∫¬—Èß‡™◊ÈÕ‰«√— ‰¢âÀ«—¥„À≠à™π‘¥‡Õ (Flu A/H3) ¢Õß “√ °—¥πÈ”™π‘¥À¬“∫®“°·¡ß≈—°§“·≈– “√∫√‘ ÿ∑∏‘Ï

% plaque reduction μàÕ‡™◊ÈÕ‰¢âÀ«—¥„À≠à™π‘¥‡Õ∑’Ë§«“¡‡¢â¡¢âπ
μ—«Õ¬à“ß (¡‘≈≈‘°√—¡/¡‘≈≈‘≈‘μ√)
10 5 2.5 1.25 0.125

“√ °—¥πÈ”™π‘¥À¬“∫®“°·¡ß≈—°§“ 80.28 55.62 - - -
3-(3,4-dihydroxyphenyl)lactic acid (1) - 55.63 24.63 - -
rosmarinic acid (2) - - 76.81 40.94 -
caffeic acid (3) - - -* -* 34.78
*‰¡à‰¥â∑¥ Õ∫‡π◊ËÕß®“°‡°‘¥§«“¡‡ªìπæ‘…μàÕ‡´≈≈å®“°μ—«∑”≈–≈“¬ DMSO

μ“√“ß∑’Ë 9 ƒ∑∏‘Ï¬—∫¬—Èß‡™◊ÈÕ‰«√— ‡Õ¥ å (HIV-1) ¢Õß “√ °—¥πÈ”™π‘¥À¬“∫®“°·¡ß≈—°§“·≈– “√∫√‘ ÿ∑∏‘Ï

√âÕ¬≈–¢Õß°“√¬—∫¬—Èß HIV-1 ∑’Ë§«“¡‡¢â¡¢âπ
μ—«Õ¬à“ß (‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√)

100 25 6
“√ °—¥πÈ”™π‘¥À¬“∫®“°·¡ß≈—°§“ >99 93.43 90
3-(3,4-dihydroxyphenyl)lactic acid (1) >99 98.56 90
rosmarinic acid (2) >99 >99 96.87
caffeic acid (3) 96.87 34.37 0

«‘®“√≥å
ter ¢Õß 3-(3,4-dihydroxyphenyl)lactic acid (1)

®“°º≈°“√·¬° “√ °—¥πÈ”™π‘¥À¬“∫®“° à«π ·≈– caffeic acid (3) ®“°º≈°“√∑¥ Õ∫ƒ∑∏‘Ï¬—∫¬—Èß
‡Àπ◊Õ¥‘π·¡ß≈—°§“‡æ◊ËÕÀ“ “√∑’Ë¡’ƒ∑∏‘Ï∑“ß™’«¿“æμàÕ ‡™◊ÈÕ‰«√— ‰¢âÀ«—¥„À≠à (FluA/H3) „πÀ≈Õ¥∑¥≈Õß
‰«√— ‰¢âÀ«—¥„À≠à™π‘¥‡Õ (Flu A/H3) ®π‰¥â “√ ¥â«¬‡∑§π‘§ plaque reduction æ∫«à“ “√∑—Èß “¡
∫√‘ ÿ∑∏‘Ï¥â«¬‡∑§π‘§ partition ·≈–§Õ≈—¡πå‚§√¡“ ™π‘¥¡’ƒ∑∏‘Ï¬—∫¬—Èß‡™◊ÈÕ‰«√— ‰¢âÀ«—¥„À≠à ‚¥¬ “√∫√‘ ÿ∑∏‘Ï

‚∑°√“øï·≈–°“√æ‘ Ÿ®πå Ÿμ√‚§√ß √â“ß∑“ß‡§¡’¥â«¬ 1, 2 ·≈– 3 ∑’Ë§«“¡‡¢â¡¢âπ 5, 2.5 ·≈– 0.125
‡∑§π‘§ ‡ª°‚∑√ ‚§ªï ‡¡◊ËÕ‡ª√’¬∫‡∑’¬∫°—∫√“¬ß“π ¡‘≈≈‘°√—¡/¡‘≈≈‘≈‘μ√ “¡“√∂¬—∫¬—Èß‡™◊ÈÕ‰¥â∑’Ë§à“‡©≈’Ë¬
25-27
°“√«‘®—¬ (√Ÿª∑’Ë 1, μ“√“ß∑’Ë 1-6) æ∫«à“·¬° “√ ‡∑à“°—∫ 55.63%, 76.81% ·≈– 34.78% μ“¡≈”¥—∫
‰¥â 3 ™π‘¥ ´÷Ëß‡ªìπ “√°≈ÿà¡°√¥øïπÕ≈‘§ ‰¥â·°à 3-(3,4- „π¢≥–∑’Ë “√ °—¥πÈ”™π‘¥À¬“∫®“°·¡ß≈—°§“ ∑’Ë
dihydroxyphenyl)lactic acid (C H O ) (1), §«“¡‡¢â¡¢âπ 5 ·≈– 10 ¡‘≈≈‘°√—¡/¡‘≈≈‘≈‘μ√
9 10 5
rosmarinic acid (C H O ) (2) ·≈– caffeic acid “¡“√∂¬—∫¬—Èß‡™◊ÈÕ‰¥â∑’Ë§à“‡©≈’Ë¬‡∑à“°—∫ 55.62% ·≈–
18 15 8
[3-(3,4-dihydroxyphenyl)-propenoic acid] 80.28% μ“¡≈”¥—∫ ¥—ßπ—Èπ “√∑’Ë¡’§«“¡·√ß„π°“√
(C8H4O5) (3) ‚¥¬ rosmarinic acid (2) ‡ªìπ es- ¬—∫¬—Èß‡™◊ÈÕ‰«√— ‰¢âÀ«—¥„À≠à (Flu A/H3) ®“°¡“°‰ª

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