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Abstract
Sporoderm-breaking Process for Spores of Ganoderma lucidum (Leyss. ex Fr.) Karst. by Broken-
sporoderm Machine and Ball Mill
Aekkhaluck Intharuksa*, Pramote Tipdaungta*, Panee Sirisa-ard*, Suwanna Vejabhikul*, Sunee Chansakaow*
*Department of Pharmaceutical Science, Faculty of Pharmacy, Chiang Mai University
Lingzhi (Ganoderma lucidum (Leyss. ex Fr.)) has been used to promote health and treat several diseases
for more than 2,000 years in China. Polysaccharides and triterpenoids are chemical groups found in fruiting
bodies and spores that give pharmacological effects. While similar chemical constituents were found in both
parts, some studies reported that spores revealed a stronger effect than fruiting bodies. Because of the hard-
ness of sporoderm, the bioactive compounds of the spores are difficult to release. The purpose of this study
was to investigate the appropriate process for breaking the sporoderm of Lingzhi spores. Two kinds of ma-
chines: broken-sporoderm machine and ball mill, which have similar mechanisms (impact and attrition),
were assessed to yield broken-sporoderm spores. In comparison with the principal of these machines, the
differences are transmission of energy and grinding media shape. As a result, broken-sporoderm machines
and ball mills could be used for breaking sporoderm of Lingzhi spores at a level of more than 95 per cent.
Bioactive compounds were extracted from broken spores with a 3-4 times higher yield than that of nonbroken-
sporoderm.
Key words: Ganoderma lucidum, Lingzhi spore, broken-sporoderm machine, ball mill