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˜ˆ «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“ß‡≈◊Õ° ªï∑’Ë ˜©∫—∫∑’Ë Ú æƒ…¿“§¡- ‘ßÀ“§¡ (©∫—∫‡ √‘¡) ÚııÚ

OP-15

ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–§«“¡™ÿà¡™◊ÈπμàÕº‘«Àπ—ß¢Õß “√ °—¥√”¢â“«‡°Á∫°—°„ππ’‚Õ‚´¡

Ò,Ú Ú Û Û Û
Õ√—≠≠“ ¡‚π √âÕ¬ , √¡¬å©—μ√ ™Ÿ‚μª√–æ—≤πå , Yuji Sato , Kukizo Miyamoto , Kesyin Hsueh ,
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Masahiko Abe , «√º°“ ¡‚π √âÕ¬ , ®’√‡¥™ ¡‚π √âÕ¬
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»Ÿπ¬å«‘®—¬·≈–æ—≤π“º≈‘μ¿—≥±å∏√√¡™“μ‘, ∂“∫—π«‘®—¬«‘∑¬“»“ μ√å·≈–‡∑§‚π‚≈¬’, ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à, ®. ‡™’¬ß„À¡à, ª√–‡∑»‰∑¬
Ú
§≥–‡¿ —™»“ μ√å, ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à, ®.‡™’¬ß„À¡à, ª√–‡∑»‰∑¬
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Skin Care Research and Development, Procter and Gamble (P&G), Kobe, Japan
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Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, ÚˆÙÒ
Chiba, Japan
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§≥–·æ∑¬»“ μ√å, ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à, ®.‡™’¬ß„À¡à, ª√–‡∑»‰∑¬

À≈—°°“√·≈–‡Àμÿº≈ “√ ”§—≠ (°√¥‡øÕ√Ÿ√‘° ÕÕ‰√´“πÕ≈·≈–°√¥‰øμ‘°) „π “√ °—¥√”¢â“«¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √– ·μà
‡π◊ËÕß®“°‡ªìπ “√ª√–°Õ∫∑’Ë‰¡à§ßμ—« ®÷ß¡’°“√ª√–¬ÿ°μå‡∑§‚π‚≈¬’π“‚π‡™àππ’‚Õ‚´¡¡“„™â‡°Á∫°—° “√ ”§—≠‡À≈à“π’È‡æ◊ËÕ„™âª√–‚¬™πå
∑“ß¬“·≈–‡§√◊ËÕß ”Õ“ß

«—μ∂ÿª√– ß§å ‡æ◊ËÕ»÷°…“ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–º≈μàÕ§«“¡™ÿà¡™◊Èπ¢Õßº‘«Àπ—ß¡πÿ…¬å¢Õß‡®≈·≈–§√’¡∑’Ë¡’ à«πº ¡¢Õß “√
°—¥®“°√”¢â“«∑’Ë‡°Á∫°—°„ππ’‚Õ‚´¡

«‘∏’¥”‡π‘π°“√ ‰¥â»÷°…“ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–¢Õß‡®≈·≈–§√’¡∑’Ë¡’ à«πº ¡¢Õß “√ °—¥®“°√”¢â“«∑’Ë‡°Á∫°—°„ππ’‚Õ‚´¡‚¥¬«‘∏’
ORAC (oxygen radical absorbance capacity) ·≈– ex vivo lipid peroxidation inhibition √«¡∑—Èß»÷°…“º≈μàÕ§«“¡™ÿà¡
™◊Èπ¢Õßº‘«Àπ—ß¡πÿ…¬åÀ≈—ß„™â Ú˜ «—π‚¥¬«—¥¥â«¬ in vivo confocal Raman microspectroscopy (CRM), corneometer ·≈–

vapometer
º≈°“√»÷°…“ æ∫«à“∑—Èß‡®≈·≈–§√’¡∑’Ë¡’ à«πº ¡¢Õß “√ °—¥®“°√”¢â“«∑’Ë‡°Á∫°—°„ππ’‚Õ‚´¡¡’ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √– ‚¥¬¡’§à“

ORAC „π™à«ß Ú-Ú¯ μmolTE / g ‡ª√’¬∫‡∑’¬∫°—∫‡®≈·≈–§√’¡æ◊Èπ´÷Ëß¡’§à“„π™à«ß Òˆ-Ò¯ μmolTE / g ·≈–™à«¬¬—∫¬—Èß°“√‡°‘¥
lipid peroxidation „π human sebum Ÿß°«à“°≈ÿà¡§«∫§ÿ¡ª√–¡“≥ Ò.ı ‡∑à“ πÕ°®“°π’È®“°°“√»÷°…“„πÕ“ “ ¡—§√À≠‘ß Ò
§π·≈–ª√–‡¡‘π¥â«¬«‘∏’°“√∑’Ë·μ°μà“ß°—π Û «‘∏’¢Õß‡®≈·≈–§√’¡∑’Ë¡’ à«πº ¡¢Õß “√ °—¥®“°√”¢â“«∑’Ë‡°Á∫°—°„ππ’‚Õ‚´¡æ∫«à“„Àâ

º≈„π∑‘»∑“ß‡¥’¬«°—π ‚¥¬ “¡“√∂‡æ‘Ë¡§«“¡™ÿà¡™◊Èπ„Àâ·°àº‘«Àπ—ß∫π·¢π¢ÕßÕ“ “ ¡—§√‰¥â Ú, Û ·≈– Û % ‡∑’¬∫°—∫‰¡à‰¥â∑“
¥â«¬μ—«Õ¬à“ß‡¡◊ËÕ«—¥¥â«¬‡§√◊ËÕß corneometer, vapometer ·≈– CRM μ“¡≈”¥—∫
¢âÕ √ÿª º≈°“√»÷°…“π’È‰¥â· ¥ß„Àâ‡ÀÁπ∂÷ß¢âÕ¥’¢Õßπ’‚Õ‚´¡„π°“√™à«¬‡æ‘Ë¡ƒ∑∏‘Ïμâ“πÕπÿ¡Ÿ≈Õ‘ √–·≈–§«“¡™ÿà¡™◊Èπ·°àº‘«Àπ—ß

‡π◊ËÕß®“°°“√‡æ‘Ë¡§«“¡§ßμ—«¢Õß “√ ”§—≠„π “√ °—¥®“°√”¢â“«‡¡◊ËÕ‡°Á∫°—°„ππ’‚Õ‚´¡

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