Page 74 - journal-6-2-S-Full

Journal of Thai Traditional & Alternative Medicine Vol. 6 No. 2 May-August (Supplement) 2008 ˜Û

OR-33

¢âÕ°”Àπ¥§ÿ≥¿“æ∑“߇§¡’¢Õß “√ °—¥¥â«¬πÈ”¢Õß∫—«∫°

Ò Ú Ò Û Ò,Û
®‘√“πÿ™ ¡‘Ë߇¡◊Õß , ®“√’¬å ∫—π ‘∑∏‘Ï , ª√–‰æ «ß»å ‘π§ß¡—Ëπ , Õ—»«™—¬ ™à«¬æ√¡ , ∏‘¥“√—µπå ∫ÿ≠√Õ¥
Ò Ú Û
»Ÿπ¬åµ√«® Õ∫·≈–√—∫√Õߧÿ≥¿“æ ¡ÿπ‰æ√, ÀâÕߪؑ∫—µ‘°“√惰…»“ µ√å, ‚√ßß“πµâπ·∫∫º≈‘µº≈‘µ¿—≥±å ¡ÿπ‰æ√
∂“∫—π«‘®—¬ ¡ÿπ‰æ√ °√¡«‘∑¬“»“ µ√å°“√·æ∑¬å °√–∑√«ß “∏“√≥ ÿ¢ ®.ππ∑∫ÿ√’ ÒÒ

À≈—°°“√·≈–‡Àµÿº≈ ∫—«∫° ¡’™◊ËÕ«‘∑¬“»“ µ√å«à“ Centella asiatica (L.) Urban «ß»å Apiaceae (Umbelliferae) ¡ÿπ‰æ√
™π‘¥π’È¡’°“√π”¡“„™â‡ªì𬓷≈–º≈‘µ¿—≥±å ÿ¢¿“æ à«π∑’Ë„™â §◊Õ∑—Èßµâπ ·æ∑¬å·ºπ‚∫√“≥„™â∑—Èßµâπ√—°…“Õ“°“√™È”„π
∫”√ÿßÀ—«„®·≈–∫”√ÿß°”≈—ß „™â√—°…“∫“¥·º≈ œ≈œ ¡’√“¬ß“π«à“ “√ °—¥¥â«¬πÈ”¢Õß∫—«∫°¡’ “√°≈ÿà¡ triterpenes ‡™àπ asiatic
acid ·≈– madecassic acid ·≈–Õπÿæ—π∏å¢Õß triterpene ester glycosides ‡™àπ asiaticoside ·≈– madecassoside ´÷Ëß
· ¥ßƒ∑∏‘Ï∑“߇¿ —™«‘∑¬“ ‡™àπ ƒ∑∏‘Ï ¡“π·º≈·≈–≈¥°“√‡°‘¥ §’≈Õ¬¥å ≈¥°“√Õ—°‡ ∫·≈–≈¥°“√‡°‘¥·º≈„π°√–‡æ“–

Õ“À“√‡π◊ËÕß®“°¿“«–§«“¡‡§√’¬¥ ƒ∑∏‘ϵâ“π®ÿ≈™’æ ·≈–ƒ∑∏‘Ï„π°“√Àâ“¡‡≈◊Õ¥ ‡ªìπµâπ ®“°ƒ∑∏‘Ï∑“߇¿ —™«‘∑¬“∑’ËÀ≈“°À≈“¬π’È
“√ °—¥¥â«¬πÈ”¢Õß∫—«∫°®÷ß¡’»—°¬¿“æ„π°“√π”¡“æ—≤𓇪ìπº≈‘µ¿—≥±å‡æ◊ËÕ ÿ¢¿“æ

«—µ∂ÿª√– ß§å ‡æ◊ËÕ®—¥∑”‡Õ°≈—°…≥å∑“߇§¡’·≈–¢âÕ°”Àπ¥¡“µ√∞“π∑“߇§¡’¢Õß “√ °—¥¥â«¬πÈ”¢Õß∫—«∫°

«‘∏’¥Ì“‡π‘π°“√ ®—¥À“µ—«Õ¬à“ß ¡ÿπ‰æ√∫—«∫°®“°·À≈àßµà“ß Ê π” ¡ÿπ‰æ√¡“∑”„Àâ·Àâß·≈â«∫¥‡ªìπºß≈–‡Õ’¬¥ µ√«® Õ∫
‡Õ°≈—°…≥å∑“߇§¡’·≈–ª√–‡¡‘π§ÿ≥¿“æ¢Õß«—µ∂ÿ¥‘∫ ¡ÿπ‰æ√µ“¡«‘∏’„π Thai Herbal Pharmacopoeia Supplement 2003
π”«—µ∂ÿ¥‘∫ ¡ÿπ‰æ√∫—«∫°∑’ˉ¥â¡“µ√∞“π¡“‡µ√’¬¡‡ªìπ “√ °—¥¥â«¬πÈ” π” “√ °—¥∑’ˉ¥â¡“»÷°…“«‘®—¬‡æ◊ËÕÀ“«‘∏’µ√«® Õ∫

‡Õ°≈—°…≥å∑“߇§¡’ ·≈–µ√«®«‘‡§√“–ÀåÀ“§ÿ≥ ¡∫—µ‘‡©æ“–µ—«Õ◊Ëπ Ê ‰¥â·°à ª√‘¡“≥ “√ °—¥¥â«¬‡Õ∑“πÕ≈·≈– ı%
‡Õ∑“πÕ≈ ª√‘¡“≥§«“¡™◊Èπ ·≈–¥—™π’°“√‡°‘¥øÕß ‡æ◊ËÕ®—¥∑”‡°≥±å¡“µ√∞“π‡∫◊ÈÕßµâπ

º≈°“√»÷°…“ æ∫«à“ “√ °—¥¥â«¬πÈ”¢Õß∫—«∫°„Àâº≈∫«°‡¡◊ËÕµ√«® Õ∫ªØ‘°‘√‘¬“°“√‡°‘¥ ’¥â«¬«‘∏’ Liebermann - Burchard
test ·≈–°“√∑¥ Õ∫°“√‡°‘¥øÕßæ∫«à“‡°‘¥øÕß∑’˧ߵ—«π“π‡°‘π Û π“∑’ °“√µ√«® Õ∫‡Õ°≈—°…≥å∑“߇§¡’¥â«¬«‘∏’
√ߧ‡≈¢º‘«∫“ßæ∫ “√ asiaticoside, asiatic acid, madecassoside, ·≈– madecassic acid πÕ°®“°π’È°“√À“ª√‘¡“≥§«“¡™◊Èπ

¥â«¬«‘∏’ loss on drying æ∫«à“¡’ª√‘¡“≥§«“¡™◊Èπ‰¡à‡°‘π√âÕ¬≈– ÒÙ. ± Û.ÚÙ ‚¥¬πÈ”Àπ—° ª√‘¡“≥ “√ °—¥¥â«¬
‡Õ∑“πÕ≈ (ethanol soluble extractive) ‰¡àπâÕ¬°«à“√âÕ¬≈– Ò. ± Ù.ıı ‚¥¬πÈ”Àπ—° ª√‘¡“≥ “√∑’ˉ¡à≈–≈“¬„π
ı% ‡Õ∑“πÕ≈ (50% ethanol insoluble matter) ‰¡à¡“°°«à“√âÕ¬≈– ÒÚ. ± Ò.˜¯ ‚¥¬πÈ”Àπ—°·≈–¥—™π’°“√‡°‘¥øÕß
(foaming index) ‰¡àπâÕ¬°«à“ ÛÛÛ ± Û.ÚÛ

¢âÕ √ÿª ¢âÕ°”Àπ¥§ÿ≥¿“æ∑“߇§¡’¢Õß “√ °—¥¥â«¬πÈ”¢Õß∫—«∫°§«√¡’ª√‘¡“≥§«“¡™◊Èπ‰¡à‡°‘π√âÕ¬≈– ÒÙ, ª√‘¡“≥ ‘Ëß

°—¥∑’Ë≈–≈“¬„π‡Õ∑“πÕ≈ ‰¡àπâÕ¬°«à“√âÕ¬≈– Ò, ª√‘¡“≥ ‘Ëß °—¥∑’ˉ¡à≈–≈“¬„π ı% ‡Õ∑“πÕ≈‰¡à‡°‘π√âÕ¬≈– ÒÚ,
¥—™π’°“√‡°‘¥øÕ߉¡àπâÕ¬°«à“ ÛÛÛ