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endothelial cells is a ROS-mediated pathway. Environ Chowdhury C, Chatterjee M, Das P. Andrographolide
Toxicol Pharmacol. 2014;37(2):718-28. analogue induces apoptosis and autophagy mediated
39. Xu J, Xue T, Bao Y, Wang DH, Ma BL, Yin CY, Yang GH, cell death in U937 cells by inhibition of PI3K/akt/mTOR
Ren G, Lan LJ, Wang JQ, Zhang XL, Zhao YQ. Positive pathway, PLoS One. 2015;10:e0139657.
therapy of andrographolide in vocal fold leukoplakia. Am 50. Hsieh MJ, Lin CW, Chiou HL, Yang SF, Chen MK.
J Otolaryngol. 2014;35(2):77-84. Dehydroandrographolide, an iNOS inhibitor, extracted
40. Sukardiman H, Sismindari AW, Zaini NC. Apoptosis from Andrographis paniculata (Burm.f.) Nees, induces
inducing effect of andrographolide on TD-47 human autophagy in human oral cancer cells. Oncotarget.
breast cancer cell line. Afr J Tradit Complement Altern 2015;6(31):30831-49.
Med. 2007;4(3):345-51. 51. Bhummaphan N. Induction of cholangiocarcinoma
41. Yang L, Wu D, Luo K, Wu S, Wu P. Andrographolide cells apoptosis by an andrographolide analog. Scientific
enhances 5- fluorouracil-induced apoptosis via caspase- Research and Essays. 2013;8(1):26-31.
8-dependent mitochondrial pathway involving p53 52. Lin HC, Su SL, Lu CY, Lin AH, Lin WC, Liu CS, Yang
participation in hepatocellular carcinoma (SMMC-7721) YC, Wang HM, Lii CK, Chen HW. Andrographolide
cells. Cancer Lett. 2009;276(2):180-8. inhibits hypoxia-induced HIF-1alphadriven endothelin
42. Yunos NM, Mutalip SS, Jauri MH, Yu JQ, Huq F. Anti- 1 secretion by activating Nrf2/HO-1 and promoting the
proliferative and pro-apoptotic effects from sequenced expression of prolyl hydroxylases 2/3 in human endo-
combinations of andrographolide and cisplatin on ovar- thelial cells. Environ Toxicol. 2017;32(3):918-30.
ian cancer cell lines. Anticancer Res. 2013;33(10):4365- 53. Jiang CG, Li JB, Liu FR, Wu T, Yu M, Xu HM. Androgra-
71. pholide inhibits the adhesion of gastric cancer cells
43. Pratheeshkumar P, Sheeja K, Kuttan G. Androgra- to endothelial cells by blocking E-selectin expression.
pholide induces apoptosis in B16F-10 melanoma cells Anticancer Res. 2007;27(4B):2439-47.
by inhibiting NF-kappaB-mediated bcl-2 activation and 54. Chao CY, Lii CK, Hsu YT, Lu CY, Liu KL, Li CC, Chen
modulating p53-induced caspase-3 gene expression. HW. Induction of heme oxygenase-1 and inhibition of
Immunopharmacol Immunotoxicol. 2012;34(1):143-51. TPA-induced matrix metalloproteinase- 9 expression by
44. Li J, Cheung HY, Zhang Z, Chan GK, Fong WF. An- andrographolide in MCF-7 human breast cancer cells.
drographolide induces cell cycle arrest at G2/M phase Carcinogenesis. 2013;34(8):1843-51.
and cell death in HepG2 cells via alteration of reactive 55. Luo W, Liu Y, Zhang J, Luo X, Lin C, Guo J. Androgra-
oxygen species. Eur J Pharmacol. 2007;568(1-3):31-44. pholide inhibits the activation of NF-kappaB and MMP-9
45. Yang EJ, Song KS. Andrographolide, a major component activity in H3255 lung cancer cells. Exp Ther Med.
of Andrographis paniculata leaves, has the neuroprotec- 2013;6(3):743-6.
tive effects on glutamate-induced HT22 cell death. J 56. Wu ZW, Xu HW, Dai GF, Liu MJ, Zhu LP, Wu J, Wang YN,
Funct Foods. 2014;9:162-72. Wu FJ, Zhao D, Gao MF, Nie SS, Han W, Song JH, Liu
46. Zhai Z, Qu X, Yan W, Li H, Liu G, Liu X, Tang T, Qin A, HM. Improved inhibitory activities against tumor-cell
Dai K. Andrographolide prevents human breast cancer- migration and invasion by 15-benzylidene substitution
induced osteoclastic bone loss via attenuated RANKL derivatives of andrographolide. Bioorg Med Chem Lett.
signaling. Breast Cancer Res Treat. 2014;144(1):33-45. 2013;23(23):6421-6.
47. Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, 57. Sheeja K, Guruvayoorappan C, Kuttan G. Antiangio-
Chowdhury C, Chatterjee M, Das P. Andrographolide genic activity of Andrographis paniculata extract and
analogue induces apoptosis and autophagy mediated andrographolide. Int Immunopharm. 2007;7:211-21.
cell death in U937 cells by inhibition of PI3K/akt/mTOR 58. Lin HH, Tsai CW, Chou FP, Wang CJ, Hsuan SW,
pathway. PLoS One. 2015;10(10):e0139657. Wang CK, Chen JH. Andrographolide down-regulates
48. Sharifuddin Y, Parry EM, Parry JM. The genotoxicity and hypoxia-inducible factor-1alpha in human non-small
cytotoxicity assessments of andrographolide in vitro. cell lung cancer A549 cells. Toxicol Appl Pharmacol.
Food Chem Toxicol. 2012;50(5):1393-8. 2011;250(3):336-45.
49. Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, 59. Li J, Zhang C, Jiang H, Cheng J. Andrographolide