Page 219 - J Trad Med 21-1-2566

J Thai Trad Alt Med Vol. 21 No. 1 Jan-Apr 2023 199

Safety and Results of Preliminary Treatment of Atopic Dermatitis with
Acanthus vulgaris–Pepper Drug Formula at U-Thong Hospital: Historical
Analysis of Data from 2012 to 2017
Pimchanok Limsakul *,** , Dalicha Changsiripron , Orasa Opaswattana , Wandee Yanpaisan ,
*
†
*
Banlue Sangthong , Suraphon Thanakarakijkul , Kulthanit Wanarat , Monthaka Teerachaisakul ,
§
#
‡
¶
Krit Pongpirul +
Uthong Hospital, Suphan Buri 72160, Thailand
*
Faculty of Pharmacy, Silpakorn University, Nakorn Pathom 73000, Thailand
†
Mahasarakham University, Maha Sarakham 44150, Thailand
‡
Chiang Mai University, Chiang Mai 50200, Thailand
§
Thai Traditional Medicine Research Institute, Department of Thai Traditional and Alternative Medicine,
¶
Bangkok 10110, Thailand
Division of Herb for Economy Department of Thai Traditional and Alternative Medicine,
#
Nonthaburi 11000, Thailand
Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University,
+
Bangkok 10330, Thailand
**Corresponding author: pimlimkul@gmail.com
Abstract
This retrospective study aimed to determine the safety and preliminary outcomes of U-Thong Hospital’s
Acanthus ilicifolius L. and Piper nigrum L. formula in treating patients with atopic dermatitis. The study involved
a review of the medical records of patients with atopic dermatitis diagnosed by a modern physician and the patients
had received 2 300-mg capsules of A. ilicifolius and P. nigrum formula, before meals 3 times a day, continuously
for at least 4 weeks, during 2012–2017 at U-Thong Hospital, Suphan Buri province. The research instrument was
the EASI Score Assessment Form. Data were collected and then analyzed using descriptive statistics. Of all 78
patients who had received the treatment for at least 4 weeks, 25.64% were aged 51–60 years, 35.90% were male.
Among those in Group 1, having received only medicinal A. ilicifolius and P. nigrum formula, 70% had improved
symptoms, compared with 76% improvements in Group 2 patients who had received the A. ilicifolius and P. nigrum
formula plus modern medications. Thus, the effects after the treatments with the herbal formula only and with
herbal plus modern medicines were not different; and there were no adverse reactions in the herbal only treatment
group.
Key words: Acanthus ilicifolius L. and Piper nigrum L., atopic dermatitis

บทนำ�และวัตถุประสงค์ มีปฏิกิริยาตอบสนองต่อสารนั้นมากผิดปกติ ภาย

โรคภูมิแพ้ผิวหนังเกิดจากการที่ร่างกายได้รับ หลังเมื่อได้รับสารนั้นเข้าไปอีก ภูมิคุ้มกันดังกล่าวก็
สารก่อภูมิแพ้ (allergens) หรือ สิ่งกระตุ้นเข้าไปใน จะกระตุ้นให้เกิดอาการ ซึ่งพยาธิสภาพนั้้นเกิดจาก

ร่างกาย แล้วกระตุ้นให้ร่างกายสร้างภูมิคุ้มกันและ ความผิดปกติของระบบภูมิคุ้มกันในร่างกายที่ท�างาน