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√ ° æ å· π
√ °“ æ ¬å· π ∑¬· –° · ∑¬ ß ≈ °å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° °
«“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬
°“√μàÕμâ“π‚√§¿Ÿ¡‘·æ⮓°æ◊™«ß»å¢‘ß °“√»÷°…“Õߧåª√–°Õ∫∑“߇§¡’¢ÕßÀ≠â“≈‘Èπߟ (Hedyotis

ÿ¿‘≠≠“ μ‘Ϋμ√–°Ÿ≈, π—Ëπ »ÿ¿∏’√ °ÿ≈ corymbosa Lamk.) ‚¥¬π”¡“·¬°¥â«¬«‘∏’‚§√¡“‚∑°√“øï æ∫
¿“§«‘™“‡¿ —™‡«∑·≈–‡¿ —™æƒ°…»“ μ√å §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬ “√ª√–°Õ∫ 7 ™π‘¥§◊Õ aurantiamide acetate (1), 3β-
ߢ≈“π§√‘π∑√å acetylaleuritolic acid (2), salicylic acid (3), b-sitosteryl-

Journal of Ethnopharmacology 2007;109(3):535-8. 3-O-b-D-glucopyranoside (6),1,5-anhydroglucitol (7)
π”æ◊™„π«ß»å¢‘ß®”π«π 6 ™π‘¥ ‰¥â·°à ¢¡‘Èπ¢“« (Curcuma ·≈– “√º ¡¢Õß 22,23-dihydrochondrillasterol (4) ·≈–
mangga) ‡ª√“–ÀÕ¡ (Kaempferia galangal) °√–™“¬¥” chondrillasterol (5) “√ª√–°Õ∫ (1) ‡ªìπ “√‰¥‡ªª‰∑¥å∑’Ë

(Kaempferia parviflora) ‰æ≈ (Zingiber cassumunar) ¢‘ß ·¬°‰¥â§√—Èß·√°®“°æ◊™ °ÿ≈π’È °“√æ‘ Ÿ®π傧√ß √â“ߢÕß “√„™â
(Zingiber officinale) ·≈–°√–∑◊Õ (Zingiber zerumbet) ‚¥¬ ‡∑§π‘§∑“ß ‡ª°‚∑√ ‚°ªï π” “√ °—¥·≈– “√∫√‘ ÿ∑∏‘Ï∑’Ë·¬°

π”‡Àßâ“¢Õßæ◊™∑—Èß 6 ™π‘¥¡“ °—¥¥â«¬·Õ≈°ÕŒÕ≈å·≈–πÈ” √«¡ ‰¥â¡“∑¥ Õ∫§«“¡‡ªìπæ‘…μàÕ‡´≈≈å¡–‡√Áßæ∫«à“ “¡“√∂μàÕ
∑—ÈßπÈ”¡—πÀÕ¡√–‡À¬π”¡“∑¥ Õ∫°—∫‡´≈≈å‡æ“–‡≈’È¬ß™π‘¥ RBL- μâ“π¡–‡√Á߇¡Á¥‡≈◊Õ¥¢“« (P388) ‰¥â.
2H3 °√–™“¬¥” (Kaempferia parviflora) ∑’Ë °—¥¥â«¬

·Õ≈°ÕŒÕ≈å· ¥ßªØ‘°‘√‘¬“°“√μàÕμâ“π‚√§¿Ÿ¡‘·æâ Ÿß∑’Ë ÿ¥ ª√– ‘∑∏‘¿“æ¢Õß ¡ÿπ‰æ√‰∑¬∑’Ë¡’μàÕ‚√§‡√‘¡™π‘¥∑’Ë 1
ª√– ‘∑∏‘¿“æ¢Õß°“√μàÕμâ“π∑’ˇ°‘¥®“°°“√°√–μÿâπ¥â«¬·Õπ쑇®π ∑—Èß„πÀ≈Õ¥∑¥≈Õß·≈–„π —μ«å∑¥≈Õß
* † ‡
∑”„Àâ¡’°“√ª≈¥ª≈àÕ¬ β-hexosaminidase ´÷Ëß„™â‡ªìπμ—«μ‘¥μ“¡ Vimolmas Lipipun , Masahiko Kurokawa , Rutt Suttisri ,
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°“√∑”≈“¬·°√ππŸ„π‡´≈≈å RBL-2H3 ‚¥¬¡’§à“ IC ‡∑à“°—∫ Pagorn Taweechotipatr*, Pornpen Pramyothin , Masao
50
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10.9 μg/ml μ“¡¡“¥â«¬ ‰æ≈ (Zingiber cassumunar) ∑’Ë Hattori , Kimiyasu Shiraki
°—¥¥â«¬·Õ≈°ÕŒÕ≈å IC = 12.9 μg/ml ·≈– ¢¡‘Èπ¢“« (Cur- *¿“§«‘™“®ÿ≈™’««‘∑¬“ §≥–‡¿ —™»“ μ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬
50
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cuma mangga) ∑’Ë °—¥¥â«¬πÈ”‚¥¬¡’ IC = 36.1 μg/ml Department of Virology, Toyama Medical and Pharmaceutical
50
πÈ”¡—πÀÕ¡√–‡À¬®“°æ◊™∑—Èß 6 ™π‘¥ ‰¡à· ¥ßƒ∑∏‘Ï„π°“√μàÕ University, 2630 Sugitani, Toyama 939-0194, Japan
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μâ“πÕ“°“√·æâ (IC > 100 μg/ml) πÕ°®“°π’Ȭ—ß∑”°“√∑¥ Õ∫ ¿“§«‘™“惰…»“ μ√凿 —™ §≥–‡¿ —™»“ μ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬
50
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“√ °—¥À¬“∫∑’Ë¡’μàժؑ°‘√‘¬“¢Õ߇Õπ‰´¡å β-hexosaminidase ¿“§«‘™“‡¿ —™«‘∑¬“ §≥–‡¿ —™»“ μ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬
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‡æ◊ËÕ‡°‘¥§«“¡™—¥‡®π«à“ “√ °—¥À¬“∫‡À≈à“π’ȉª¡’º≈μàÕ°“√ Institute of Natural Medicine, Toyama Medical and Pharmaceu-
∑”ß“π¢Õ߇Õπ‰´¡åÀ√◊Õ°“√‰ª∑”≈“¬·°√πŸ º≈®“°°“√»÷°…“ tical University, 2630 Sugitani, Toyama 939-0194, Japan
æ∫«à“ “√ °—¥À¬“∫‰¡à¡’º≈μàÕ°“√∑”ß“π¢Õ߇Õπ‰´¡å β-hex- Antiviral Research 2003;60(3):175-80.

osaminidase °“√∑¥ Õ∫§√—Èßπ’ȇªìπ°“√ π—∫ πÿπ„Àâ‡ÀÁπ«à“ π” ¡ÿπ‰æ√‰∑¬®”π«π 20 ™π‘¥¡“ °—¥‡æ◊ËÕª√–‡¡‘πº≈
¿Ÿ¡‘ªí≠≠“‰∑¬∑’Ë¡’°“√„™âæ◊™„π«ß»å¢‘ß ‚¥¬‡©æ“–Õ¬à“߬‘Ëß μàÕ°“√√—°…“‚√§‡√‘¡∑’ˇ°‘¥®“°‰«√— ™π‘¥∑’Ë 1 (HSV-1) „π
°√–™“¬¥”·≈–‰æ≈„π°“√√—°…“Õ“°“√·æâ·≈–‚√§∑’ˇ°’ˬ«°—∫ ®”π«ππ’È¡’æ◊™‡æ’¬ß 11 ™π‘¥ ∑’Ë “¡“√∂¬—∫¬—Èß°“√ÕÕ°μÿà¡∑’Ë

°“√·æâμà“ß Ê ‡°‘¥®“°‡™◊ÈÕ HSV-1 ‰¥â¡“°°«à“√âÕ¬≈– 50 ∑’˧«“¡‡¢â¡¢âπ 100
μg/ml ª√–¬ß§å (Aglaia odorata) ¡–√ÿ¡ (Moringa oleifera)
Õߧåª√–°Õ∫∑“߇§¡’·≈–§«“¡‡ªìπæ‘…μàÕ‡´≈≈å¢ÕßÀ≠â“ ·≈–√“ß·¥ß (Ventilago denticulate) ‡ªìπæ◊™„π°≈ÿà¡ 11 ™π‘¥

≈‘Èπߟ ∑’Ë¡’ª√– ‘∑∏‘¿“æ„π°“√μàÕμâ“π thymidine kinase-deficient
ÿπ—π∑å ™—¬π–°ÿ≈*, °¡≈«√√≥ Õπ—πμå*, ®‘𥓠·μâ¡∫√√®ß*, HSV-1 ·≈– phosphonoacetate-resistant HSV-1 strains.
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æ√∑‘æ“ æ‘™“ ª√– ‘∑∏‘¿“æ¢Õß°“√√—°…“‡√‘¡∑’Ë∑”„À⇰‘¥‡™◊ÈÕ∫πº‘«Àπ—ߢÕß
*¿“§«‘™“‡§¡’ §≥–«‘∑¬“»“ μ√å ¡À“«‘∑¬“≈—¬»√’π§√‘π∑√«‘‚√≤ ÀπŸæ∫«à“ “√ °—¥®“°¡–√ÿ¡¢π“¥ 750 ¡‘≈≈‘°√—¡/πÈ”Àπ—°μ—« 1
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∂“∫—π¡–‡√Áß·Ààß™“μ‘ °‘‚≈°√—¡/«—π ¡’º≈Õ¬à“ß¡’π—¬ ”§—≠μàÕ°“√æ—≤π“μÿà¡·º≈∑’Ë
«“√ “√¡À“«‘∑¬“≈—¬»√’π§√‘π∑√«‘‚√≤ 2553;2(3). º‘«Àπ—ß πÕ°®“°π’Ȭ—߬◊¥√–¬–‡«≈“‡©≈’ˬ¢Õß°“√√Õ¥™’«‘μ·≈–