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μ“√“ß∑’Ë 2 §«“¡ª≈Õ¥¿—¬¢Õßμ”√—∫¬“ N040 μàÕºŸâ‡¢â“√à«¡«‘®—¬‚√§¡–‡√Áß√–¬–·æ√à°√–®“¬·≈–‰¡àμÕ∫ πÕßμàÕ°“√
√—°…“¡“μ√∞“π‡ª√’¬∫‡∑’¬∫°àÕπ·≈–À≈—ß√—∫ª√–∑“𬓠(n = 32)

º≈°“√μ√«®‡≈◊Õ¥∑“ßÀâÕߪؑ∫—μ‘°“√ °àÕπ À≈—ß p-value

°“√μ√«®§«“¡ ¡∫Ÿ√≥å¢Õ߇¡Á¥‡≈◊Õ¥ (Complete Blood Count: §à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π)
§à“Œ’‚¡‚°≈∫‘π (Hemoglobin) 11.30 ± 1.32 11.20 ± 1.90 0.346
§à“§«“¡‡¢â¡¢âπ¢Õ߇≈◊Õ¥ (Hematocrit) 34.40 ± 4.30 34.11 ± 5.70 0.362
®”π«π‡¡Á¥‡≈◊Õ¥¢“« (White Blood Cell) 6495.50 ± 2008.6 8809.10 ± 9360.90 0.154
%Neutrophil 64.84 ± 10.40 70.50 ± 11.62 0.028*
Absolute neutrophil 4291.10 ± 1682.70 5272.00 ± 4408.93 0.278
®”π«π‡°≈Á¥‡≈◊Õ¥ (Platelet) 298031.30 ± 77600.50 312812.50 ± 103325.17 0.232

°“√μ√«®°“√∑”ß“π¢Õ߉μ (§à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π)
Blood Urea Nitrogen (BUN) 11.12 ± 3.80 12.80 ± 4.82 0.006*
Serum Creatinine 1.41 ± 2.40 1.00 ± 0.23 0.313

°“√μ√«®°“√∑”ß“π¢Õßμ—∫ (§à“‡©≈’ˬ ± à«π‡∫’ˬ߇∫π¡“μ√∞“π)
Alkaline phosphatase (ALP) 81.70 ± 23.40 108.70 ± 64.80 0.011*
Asparate aminotransferase (AST) 26.43 ± 9.60 28.43 ± 11.10 0.751
Alanine aminotransferase (ALT) 20.21 ± 15.00 21.12 ± 13.70 0.874
Total Bilirubin 0.50 ± 0.21 0.51 ± 0.21 0.131
Total Protein 7.84 ± 0.83 7.60 ± 0.90 0.291
Albumin 4.02 ± 0.41 3.82 ± 0.70 0.073
Globulin 3.84 ± 0.84 3.82 ± 1.11 0.560
À¡“¬‡Àμÿ: p < 0.05; * §◊Õ ¡’§«“¡·μ°μà“ß°—πÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘쑇¡◊ËÕ«‘‡§√“–Àå¥â«¬ repeated One-way ANOVA

º≈°“√ª√–‡¡‘πª√– ‘∑∏‘º≈‡∫◊ÈÕßμâπ¢Õßμ”√—∫¬“ ”§—≠∑“ß ∂‘μ‘·≈–¬—ßÕ¬Ÿà„π™à«ß‡°≥±åª√–‡¡‘πº≈

N040 μàÕºŸâ‡¢â“√à«¡«‘®—¬¢Õß‚§√ß°“√æ∫«à“ §à“ CEA ‡¥’¬«°—π √“¬≈–‡Õ’¬¥¥—ßμ“√“ß∑’Ë 3
·≈–§à“ CA19-9 ¡’·π«‚π⡇æ‘Ë¡¢÷ÈπÀ≈—߉¥â√—∫¬“ N040 º≈ª√–‡¡‘π°“√μÕ∫ πÕßμàÕ¬“ N040 μ“¡
·μà‰¡à·μ°μà“ß°—πÕ¬à“ß¡’π—¬ ”§—≠∑“ß ∂‘μ‘ ∑—Èßπ’È RECIST criteria æ∫«à“ ºŸâ‡¢â“√à«¡«‘®—¬®”π«π 20 √“¬

§–·ππ‡©≈’ˬ§ÿ≥¿“æ™’«‘μ‡¡◊ËÕª√–‡¡‘π¥â«¬·∫∫ (√âÕ¬≈– 62.5) μÕ∫ πÕßμàÕ°“√‰¥â√—∫¬“ N040
ª√–‡¡‘π Thai modified function living index ‚¥¬‡ªìπ°“√μÕ∫ πÕß·∫∫ complete response
cancer questionnaire version 2 (T-FLIC 2) ®”π«π 4 √“¬, ·∫∫ partial response ®”π«π 12

´÷Ë߇ªìπ‡§√◊ËÕß¡◊Õ∑’Ë„™âª√–‡¡‘π¿“«–°“√∑”Àπâ“∑’Ë √“¬ ·≈–·∫∫ stable ®”π«π 4 √“¬ πÕ°®“°π’È
§«“¡º“ ÿ°¥â“π√à“ß°“¬ ¿“æ®‘μ„® ·≈–°“√ªØ‘ æ∫«à“¡’ºŸâªÉ«¬‡ ’¬™’«‘μ∑—Èß ‘Èπ®”π«π 12 √“¬„π√–¬–

—¡æ—π∏å¿“¬„π§√Õ∫§√—«·≈– —ߧ¡ ¡’·π«‚πâ¡≈¥ ‡«≈“ 1 ªï ¡’Õ—μ√“°“√√Õ¥™’æ∑’Ë 1 ªï §‘¥‡ªìπ√âÕ¬≈–
≈ßÀ≈—߉¥â√—∫¬“ N040 ·μà‰¡à·μ°μà“ß°—πÕ¬à“ß¡’π—¬ 62.50 √“¬≈–‡Õ’¬¥¥—ß· ¥ß„πμ“√“ß∑’Ë 4 ·≈–√Ÿª∑’Ë 1