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Abstract
Physical Properties of Herbal Tablets (Jit Tra Rom Recipe) Prepared by Wet Granula-
tion Method
Chaowalit Monton*, Worawan Saingam, Jirapornchai Suksaeree, Apirak Sakunpak
Sino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin
Institute of Technology, and Heilongjiang University of Chinese Medicine) Faculty of Pharmacy, Rangsit
University, Muang, Pathum Thani 12000
Corresponding author: chaowalit@rsu.ac.th

The aim of this study was to develop the formulation and evaluate the physical properties
of herbal tablets (Jit Tra Rom recipe) that were prepared by the wet granulation method. Five
parameters of physical properties were investigated: weight variation, friability, thickness, hard-
ness, and disintegration time. Seven formulas of the herbal tablets were formulated. Each for-
mula consisted of 500 milligrams of herbal powder and 150 milligrams of excipients as well as 1%
or 3% of binder (povidone K 30), 3% or 5% of disintegrant (sodium starch glycolate, croscarmellose
sodium, or crospovidone), 1% of glidant (colloidal silicon dioxide), 1% of lubricant (magnesium
stearate), and avicel PH 102 as a tablet diluent. All the herbal formulas had a low weight varia-
tion and low friability of 0.29-0.99% and 0.06-0.15%, respectively. They had 6.36-6.63 millime-
ters of thickness and 4.36-6.58 kiloponds of hardness. All 7 herbal tablets fully disintegrated
within 12 minutes, 4 of which disintegrated within 5 minutes and 2 revealed a fast disintegrating
property. Therefore, all the herbal tablets met the criteria of the United State Pharmacopoeia
and the British Pharmacopoeia.
Key words: physical properties, herbal tablets, wet granulation, Jit Tra Rom