Page 76 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 11 ฉบับที่ 3
P. 76

Journal of Thai Traditional & Alternative Medicine  Vol. 11 No. 3 September-December 2013 285


                                                                   3
                                                         ∑“߇§¡’¥—ßπ’È
               °“√∫Ÿ√ ( —߇§√“–Àå)  ((KARABOON)

               (SYNTHETIC))

                   Camphora Syntheticum
                                                                                 ·≈–Õ’·ππ∑‘‚Õ‡¡Õ√å
                   Synthetic Camphor
                                                                                 (enantiomer)
                   °“√∫Ÿ√ ( —߇§√“–Àå) ‰¥â®“°°“√ —߇§√“–Àå∑“ß
               ‡§¡’ ¡—°‡√‘Ë¡μâπ®“° “√·Õ≈ø“-‰æπ’π (α-pinene)
               ®“°πÈ”¡—π π (turpentine oil) ‰¥â‡ªìπ°“√∫Ÿ√ (dl-  ≈—°…≥–‡§√◊ËÕ߬“ °“√∫Ÿ√¡’≈—°…≥–‡ªìπº≈÷°

               Camphor) ´÷Ë߇ªìπ¢Õߺ ¡·√´‘¡‘° (racemic mix-  ‡≈Á°Ê „  ‚ª√àß· ß À√◊Õ ’¢“« ‡¡◊ËÕ∑‘È߉«â∫“ß à«πÕ“®
                   1,2
               ture)                                     ®—∫‡ªìπ°âÕπ ‡√’¬°«à“ flowers of camphor ¡’°≈‘Ëπ
                   ™◊ËÕ‡§¡’ (1RS,4RS)-1,7,7-trimethylbicyclo  ÀÕ¡©ÿπ‡©æ“–μ—« ¡’√ ¢¡‡≈Á°πâÕ¬ √âÕπª√à“·≈â«
                                                                          5
               [2.2.1]heptan-2-one, (±)-camphor, dl-camphor,  μ“¡¥â«¬§«“¡√Ÿâ ÷°‡¬Áπ
                                       2-4
               2-bornanone, 2-camphanone                      «‘∏’°“√‡μ√’¬¡
                    ¡∫—μ‘∑“߇§¡’ °“√∫Ÿ√ ( —߇§√“–Àå) ‡ªìπ     „πÕÿμ “À°√√¡¡—°‡√‘Ë¡μâπ®“° “√·Õ≈ø“‰æπ’π

                “√ª√–°Õ∫Õ‘π∑√’¬å ª√–‡¿∑¡Õ‚π‡∑Õ√åæ’π§’‚∑π  Õ—π‡ªìπ “√À≈—°∑’Ëæ∫„ππÈ”¡—π π ‚¥¬Õ“®ºà“π ªØ‘
               (monoterpene ketone) ‡≈¢∑–‡∫’¬π CAS 76-22-  °√‘¬“‡§¡’ 3 ¢—ÈπμÕπ §◊Õ ‡ª≈’ˬπ “√·Õ≈ø“‰æπ’π
               2 ¡’ Ÿμ√‚¡‡≈°ÿ≈ C H O πÈ”Àπ—°‚¡‡≈°ÿ≈ 152.23  „À⇪ìπ “√∫Õ√åπ‘≈‡Õ ‡∑Õ√å (bornyl ester) ´÷Ë߇¡◊ËÕ
                             10 16
               §à“§«“¡∂à«ß®”‡æ“– 0.992 ®ÿ¥À≈Õ¡‡À≈« 174-181  ∂Ÿ°‰Œ‚¥√‰≈´å (hydrolyzed) ®–‰¥â “√‰Õ‚´∫Õ√åπ’ÕÕ≈

               Õß»“‡´≈‡´’¬  ‡¡◊ËÕ∑‘È߉«â„πÕ“°“»®–√–‡À‘¥‰¥â™â“ Ê  (isoborneol) ‡¡◊ËÕπ” “√π’ȉªÕÕ°´‘‰¥´å (oxidized)
                                                                  1,8
               ∑’ËÕÿ≥À¿Ÿ¡‘ÀâÕß √–‡À¬ßà“¬‡¡◊ËÕ —¡º— ‰ÕπÈ” ≈–≈“¬„π  ®–„Àâ°“√∫Ÿ√
               πÈ”‰¥â¬“° ‰¡à≈–≈“¬„π°≈’‡´Õ√’π (glycerin) ·μà°“√∫Ÿ√  °“√ —߇§√“–Àå°“√∫Ÿ√∑“ßÕÿμ “À°√√¡Õ’°«‘∏’Àπ÷Ëß
               1  à«π ≈–≈“¬‰¥â„ππÈ”¡—π¡–°Õ° (olive oil) 4  à«π  §◊Õ π”·Õ≈ø“‰æπ’π¡“∑”ªØ‘°√‘¬“°—∫‰Œ‚¥√‡®π
               „ππÈ”¡—π π (turpentine oil) 1.5  à«π „π   §≈Õ‰√¥å (hydrogen chloride) ‰¥â‡ªìπ‰Õ‚´∫Õ√å
               ‡Õ∑‘≈·Õ≈°ÕŒÕ≈å (ethyl alcohol) À√◊ÕÕ’‡∑Õ√å (ether)  π‘≈§≈Õ‰√¥å (isobornyl chloride) ®“°π—Èπ∑”ªØ‘

               1  à«π ·≈–„π§≈Õ‚√øÕ√å¡ (chloroform) 0.5  à«π  °√‘¬“°—∫‚´‡¥’¬¡·Õ´’‡∑μ (sodium acetate) ·≈–
               ≈–≈“¬‰¥â¥’„ππÈ”¡—π√–‡À¬¬“° (fixed oil) ·≈–  °√¥‡°≈‡´’¬≈·Õ´’μ‘° (glacial acetic acid) ‰¥â

               πÈ”¡—π√–‡À¬ßà“¬ (volatile oil) ‡¡◊ËÕº ¡°“√∫Ÿ√°—∫  ‡ªìπ‰Õ‚´∫Õ√åπ‘≈·Õ´’‡∑μ (isobornyl acetate) ‡¡◊ËÕ
               §≈Õ√—≈‰Œ‡¥√μ (chloral hydrate) ‡°≈Á¥ –√–·Àπà  π”‰ª·¬° ≈“¬¥â«¬πÈ” (hydrolysis) ®–‰¥â‰Õ‚´
               (menthol) À√◊ÕøïπÕ≈ (phenol) ®–°≈“¬‡ªìπ   ∫Õ√åπ‘≈·Õ≈°ÕŒÕ≈å (isobornyl alcohol) ´÷Ë߇¡◊ËÕπ”
               ¢Õ߇À≈«À√◊ÕÕàÕπμ—«≈ß  “¡“√∂∫¥°“√∫Ÿ√„À⇪ìπ   “√π’ȉªÕÕ°´‘‰¥´å (oxidized) ¥â«¬°√¥‚§√¡‘°
                                                                                2
               ºß‰¥â∂â“‡μ‘¡‡Õ∑“πÕ≈√âÕ¬≈– 96 Õ’‡∑Õ√åÀ√◊Õ  (chromic acid) ®–‰¥â°“√∫Ÿ√
                                                                                            5,9
               §≈Õ‚√øÕ√塇≈Á°πâÕ¬ 2-7 °“√∫Ÿ√¡’ Ÿμ√‚§√ß √â“ß   ¢âÕ∫àß„™â ·°â√–§“¬ (counter-irritant)  ·°â
   71   72   73   74   75   76   77   78   79   80   81