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Journal of Thai Traditional & Alternative Medicine
             Journal of Thai Traditional & Alternative Medicine
             Journal of Thai Traditional & Alternative Medicine              Vol. 9 No. 1 January-August (Supplement) 2011 73
             Journal of Thai Traditional & Alternative Medicine
             Journal of Thai Traditional & Alternative Medicine
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             °“√»÷°…“ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å∫‘«‰∑√‘≈‚§≈≈’π‡Õ ‡μÕ‡√ ¢Õß ¡ÿπ‰æ√„πμ”√—∫¬“Õ“¬ÿ«—≤π–


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             ∏π—≠™π° ∑—∫∑‘¡ , ®—π∑√宑√“ Õ‘π∑√åª√– ‘∑∏‘Ï , »ÿ≥‘μ“ ¡“°™Ÿ™‘μ , æ‘¡≈«√√≥ ∑—æ¬ÿ∑∏æ‘®“√≥å
             1
             π—°»÷°…“·æ∑¬å·ºπ‰∑¬ª√–¬ÿ°μå §≥–·æ∑¬»“ μ√å ¡À“«‘∑¬“≈—¬∏√√¡»“ μ√å
             2
              “¢“«‘™“°“√·æ∑¬å·ºπ‰∑¬ª√–¬ÿ°μå §≥–·æ∑¬»“ μ√å ¡À“«‘∑¬“≈—¬∏√√¡»“ μ√å

                 À≈—°°“√·≈–‡Àμÿº≈ ‚√§Õ—≈‰´‡¡Õ√å (Alzheimer disdease, AD) ‡ªìπ‚√§ ¡Õ߇ ◊ËÕ¡™π‘¥Àπ÷Ëß´÷Ëß¡—°ª√“°ØÕ“°“√‡¡◊ËÕÕ“¬ÿ

             ¡“°¢÷Èπ „πªí®®ÿ∫—π¬—߉¡à¡’¬“∑’Ë√—°…“‚√§π’È„ÀâÀ“¬¢“¥‰¥â ¡’·μଓ∑’˙૬§«∫§ÿ¡Õ“°“√·≈–™–≈Õ°“√¥”‡π‘π¢Õß‚√§ ‚¥¬°≈‰°°“√
             ÕÕ°ƒ∑∏‘Ï∑’Ë ”§—≠¢Õ߬“¥—ß°≈à“«§◊Õƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å cholinesterase ´÷Ëß¡’º≈∑”„Àâª√‘¡“≥ “√ ◊ËÕª√– “∑ acetyl choline „π
              ¡Õ߇æ‘Ë¡¢÷Èπ „π∑“ß°“√·æ∑¬å·ºπ‰∑¬¡’μ”√—∫¬“À≈“¬μ”√—∫∑’Ë„™â‡ªìπ¬“Õ“¬ÿ«—≤π– ´÷ËßÕ“®¡’ ¡ÿπ‰æ√∑’Ë¡’ƒ∑∏‘Ïμâ“π‡Õπ‰´¡å¥—ß°≈à“«
             ·≈–π”¡“„™âª√–‚¬™π凿◊ËÕ√—°…“‚√§Õ—≈‰´‡¡Õ√剥â

                 «—μ∂ÿª√– ß§å ‡æ◊ËÕ»÷°…“ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å butyrylcholinesterase ¢Õß ¡ÿπ‰æ√∑’˧—¥‡≈◊Õ°¡“®“°μ”√—∫¬“Õ“¬ÿ«—≤π– ·≈â«
             π” ¡ÿπ‰æ√∑’Ë¡’ƒ∑∏‘Ï¥’¡“μ—È߇ªìπμ”√—∫¬“„À¡à
                 «‘∏’¥”‡π‘π°“√ §—¥‡≈◊Õ° ¡ÿπ‰æ√®“°μ”√—∫¬“Õ“¬ÿ«—≤π– 11 ™π‘¥ ‰¥â·°à °√–™“¬¥” (Boesenbergia rotunda (L.) Mansf.)
             ‚°∞‡™’¬ß (Levisticum officinale Koch.) ¢àÕ¬ (Streblus asper Lour.) ¢‘ß (Zingiber officinale L.) ß“¥” (Sesamum indicum

             Linn.) ®—π∑πå‡∑» (Myristica fragrans Linn.) ™–‡Õ¡‡∑» (Glycyrrhiza glabra Linn.) ‡∑’¬π¥” (Nigella sativa Linn.)
             ∫Õ√–‡æÁ¥ (Tinospora spinosa (L.) Meiers ex Hook.f.& Thomson) æ√‘°‰∑¬¥” (Piper Nigrum Linn.) ·≈–À—«·Àâ«À¡Ÿ
             (Cyperus rotundus Linn.) π”¡“ °—¥¥â«¬‡¡∑“πÕ≈·≈–πÈ” ·≈â«π”‰ª∑¥ Õ∫ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å butyrylcholinesterase ®“°
             π—Èπ§—¥‡≈◊Õ° ¡ÿπ‰æ√∑’Ë„Àâº≈¥’ π”¡“μ—È߇ªìπμ”√—∫¬“·≈–∑¥ Õ∫ƒ∑∏‘Ï¥—ß°≈à“«

                 º≈°“√»÷°…“ æ∫«à“ “√ °—¥¥â«¬‡¡∑“πÕ≈¢Õß‚°∞‡™’¬ß ¢‘ß ·≈–æ√‘°‰∑¬¥”  “¡“√∂¬—∫¬—È߇Õπ‰´¡å butyrylcholinesterase
             ‰¥â¥’∑’Ë ÿ¥ ‚¥¬¡’§à“§«“¡ “¡“√∂„π°“√¬—∫¬—Èß∑’Ë 50 ‡ªÕ√凴Áπμå (IC ) ‡∑à“°—∫ 396.91 ± 23.77, 53.91 ± 7.82 ·≈– 70.32 ± 4.18
                                                               50
             ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√ μ“¡≈”¥—∫  à«π “√ °—¥¥â«¬πÈ”‰¡à¡’ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å¥—ß°≈à“« ‡¡◊ËÕπ” ¡ÿπ‰æ√ 6 ™π‘¥·√°´÷Ëß¡’ƒ∑∏‘Ϭ—∫¬—Èß
             ‡Õπ‰´¡å butyrylcholinesterase ¥’∑’Ë ÿ¥ ‰¥â·°à °√–™“¬¥” ‚°∞‡™’¬ß ¢‘ß ®—π∑πå‡∑» ™–‡Õ¡‡∑» ·≈–æ√‘°‰∑¬¥” ¡“√«¡‡ªìπμ”√—∫

             „π —¥ à«π‡ ¡Õ¿“§  °—¥μ”√—∫¥â«¬«‘∏’°“√¢â“ßμâπ·≈â«π”‰ª∑¥ Õ∫ƒ∑∏‘Ï æ∫«à“  “√ °—¥¥â«¬‡¡∑“πÕ≈·≈–πÈ”¢Õßμ”√—∫¬“∑’˧«“¡
             ‡¢â¡¢âπ 0.1 ¡‘≈≈‘°√—¡/¡‘≈≈‘≈‘μ√  “¡“√∂¬—∫¬—È߇Õπ‰´¡å butyrylcholinesterase ‰¥â 30.03 ± 2.44 ·≈– 10.49 ± 1.60 ‡ªÕ√凴Áπμå
             μ“¡≈”¥—∫ ‚¥¬ “√ °—¥¥â«¬‡¡∑“πÕ≈¢Õßμ”√—∫¬“¡’§à“§«“¡ “¡“√∂„π°“√¬—∫¬—Èß∑’Ë 50 ‡ªÕ√凴Áπμå (IC ) ‡∑à“°—∫ 132.25 ± 12.68
                                                                                          50
             ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√  à«π “√ °—¥¥â«¬πÈ”¢Õßμ”√—∫¬“‰¡à¡’ƒ∑∏‘Ϭ—∫¬—È߇Õπ‰´¡å¥—ß°≈à“«

                 ¢âÕ √ÿª  ¡ÿπ‰æ√∑’˧—¥‡≈◊Õ°¡“®“°μ”√—∫¬“Õ“¬ÿ«—≤π– 6 ™π‘¥ ‰¥â·°à °√–™“¬¥” ‚°∞‡™’¬ß ¢‘ß ®—π∑πå‡∑» ™–‡Õ¡‡∑» ·≈–
             æ√‘°‰∑¬¥” ·≈–μ”√—∫¬“∑’Ëμ—Èߢ÷Èπ  “¡“√¬—∫¬—È߇Õπ‰´¡å butyrylcholinesterase ‰¥â¥’ ´÷Ëß®“°º≈°“√∑¥≈Õߥ—ß°≈à“« “¡“√∂𔉪
             „™â‡ªìπ¢âÕ¡Ÿ≈‡∫◊ÈÕßμâπ„π°“√»÷°…“·≈–æ—≤π“μ”√—∫¬“ ”À√—∫√—°…“ ¡Õ߇ ◊ËÕ¡μàÕ‰ª
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