Page 90 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 3 ฉบับที่ 1

88 «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë Û ©∫—∫∑’Ë Ò µÿ≈“§¡ ÚıÙ˜-¡°√“§¡ ÚıÙ¯

acid, 8-γ,γ -dimethylallylwighteone, 3'-γ,γ -dimethylallylwighteone ¡’ƒ∑∏‘Ϭ—∫¬—Èß cAMP-

dependent protein kinase catalytic subunit ¢Õßµ—∫ÀπŸ ‚¥¬§à“§«“¡‡¢â¡¢âπ„π°“√¬—∫¬—Èß∑’Ë 50%
À√◊Õ IC ∑’Ë 3.5, 10, 20, 24 ·≈– 33 ‰¡‚§√‚¡≈à“√å µ“¡≈”¥—∫ ·≈–‡ πÕ«à“ “√‡§¡’∑’Ë¡’ Ÿµ√
50
‚§√ß √â“߇ªìπ prenyl (À√◊Õ dimethylallyl) ¥—ß°≈à“«®”‡ªìπµàÕ°“√· ¥ßƒ∑∏‘Ï ´÷ËßÕ“®‡ªìπ‡Àµÿº≈∑’Ë
√“°‡∂“«—≈¬å‡ª√’¬ß¡’ƒ∑∏‘Ï„π°“√‡∫◊ËÕª≈“À√◊Õ¶à“·¡≈ß°Á‰¥â (11)

®“°°“√»÷°…“∑“߇§¡’ æ∫«à“ à«π≈”µâπ (‡∂“) ¢Õ߇∂“«—≈¬å‡ª√’¬ß ª√–°Õ∫¥â«¬ “√‡§¡’
ª√–‡¿∑ isoflavone ·≈– isoflavone glycoside ®”π«π¡“° ‡™àπ 5,7,4'-trihydroxy-6,3'-
(10)
(10)
(10)
diprenylisoflavone , 5,7,4-trihydroxy-6,8-diprenylisoflavone , lupinisoflavone G ,
(10)
(10)
(10)
7,8-dihydroxy-4'-methoxyisoflavone , erysenegalensein E , lupinisol A ,
(12)
(12)
eturunagarone , lupalbigenin , 3'-γ,γ -dimethylallylwighteone (8, 12) , 8-γ,γ -
(12)
(12)
dimethylallylwighteone , 3,3'-γ,γ -dimethylallylwighteone , derriscandenosides A-
(13)
(13)
E , 7,8-dihydroxy-4'-methoxyisoflavone , 8-hydroxy-4',7-dimethoxyisoflavone-8-
(13)
O-β- glucopyranoside , 7-hydroxy-4',8-dimethoxyisoflavone-7- O-β-
(13)
(13)
glucopyranoside , formononetin-7-O-β-glucopyranoside , diadzein-7- O- [α-
(13)
rhamnopyranosyl-(1→6)]-β-glucopyranoside , formononetin-7-O- [α-
(13)
rhamnopyranosyl-(1→6)]-β-glucopyranoside , genistein-7- O- [α-rhamnopyranosyl-
(15)
(1→6)]-β-glucopyranoside (8, 13) , derrisisoflavone A-F (10,14) , derriscanosides A-B ·≈–
(12)
“√°≈ÿà¡ coumarins ‡™àπ 4,4'-di-O-methyl scandenin , 4,4'-di-O-methyllonchocarpic acid (12)
12)
·≈– robustic acid ( à«π‡Àπ◊Õ¥‘π¢Õ߇∂“«—≈¬å‡ª√’¬ß¡’√“¬ß“π°“√æ∫ “√ª√–‡¿∑ steroids ‡™àπ
(16)
lupeol, taraxerol ·≈– β-sitosterol ‡ªìπµâπ à«π√“°¢Õ߇∂“«—≈¬å‡ª√’¬ß æ∫ “√°≈ÿà¡ isoflavone
(18)
(17)
(17)
‰¥â·°à warangalone (À√◊Õ scandenone) (17, 18) , scandinone , chandalone , osajin ,
(19)
(18)
(19)
nallanin ·≈– chandanin ·≈–æ∫ “√°≈ÿà¡ coumarin ‰¥â·°à lonchocarpenin , lonchocarpic
acid (18, 20) , scandenin (18-22)
°“√∑¥ Õ∫§«“¡‡ªìπæ‘…‡©’¬∫æ≈—π ‚¥¬°“√©’¥ “√ °—¥ 50 % ‡Õ∏“πÕ≈®“° à«π‡Àπ◊Õ
¥‘π‡∂“«—≈¬å‡ª√’¬ß‡¢â“™àÕß∑âÕßÀπŸ∂’∫®—°√ æ∫«à“ ¢π“¥∑’ˇªìπæ‘…∑”„ÀâÀπŸµ“¬ 50 % §◊Õ 1 °./°°. (23)
·µà‡¡◊ËÕ„Àâ‚¥¬°“√ªÑÕπ∑“ߪ“° À√◊Õ©’¥„µâº‘«Àπ—ß„π¢π“¥ 10 °./°°. °≈—∫‰¡àæ∫§«“¡‡ªìπæ‘…„¥Ê µàÕ
(24)
—µ«å∑¥≈Õß ”À√—∫°“√»÷°…“æ‘…‡√◊ÈÕ√—ß (6 ‡¥◊Õπ) π—Èπ ‰¡àæ∫§«“¡º‘¥ª°µ‘„¥Ê∑’ˇ°‘¥®“°§«“¡
‡ªìπæ‘…¢Õß “√ °—¥¥â«¬ 50 % ‡Õ∏“πÕ≈„πÀπŸ¢“« ·¡â®–„Àâ “√ °—¥‚¥¬°“√ªÑÕπ ∑“ߪ“°„π¢π“¥
6, 60, 600 ¡°./°°./«—π À√◊Õ‡∑’¬∫‡∑à“ºß‡∂“«—≈¬å‡ª√’¬ß·Àâß 0.03, 0.3, 3 °./°°./«—π À√◊Õ 1, 10,100
‡∑à“¢Õß ¢π“¥∑’Ë„™â„π§πµàÕ«—π (25)