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°“√Õ—°‡ ∫ ®–‡ÀÁπ‰¥â«à“„πÕ¥’μ‰¡à¡’°“√„™â∑ÿ‡√’¬π Õ“®®–¡’ “√ annonaceous acetogenin ≈–≈“¬
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‡∑»„π°“√√—°…“‚√§¡–‡√Áß ÕÕ°¡“„ππÈ”√âÕπ‰¥â∫â“ß
4. ß“π«‘®—¬¢Õß Gavamukulya (2014) æ∫
„∫∑ÿ‡√’¬π‡∑»∑’Ëπ”¡“μâ¡πÈ”¡’ √√æ§ÿ≥„π°“√
«à“ “√ °—¥®“°„∫∑ÿ‡√’¬π‡∑»¥â«¬πÈ” (Õÿ≥À¿Ÿ¡‘ÀâÕß)
¶à“‡´≈≈å¡–‡√Á߉¥â®√‘ßÀ√◊Õ‰¡à
‰¡à¡’ƒ∑∏‘Ϭ—∫¬—Èß°“√‡®√‘≠‡μ‘∫‚μ¢Õ߇´≈≈å¡–‡√Áßμ—∫™π‘¥
®“°°“√∑∫∑«π¢âÕ¡Ÿ≈‚¥¬ √Õß»“ μ√“®“√¬å Ehrlich Ascites Carcinoma „π∑ÿ°§«“¡‡¢â¡¢âπ
¥√.¿≠. πæ¡“» ÿπ∑√‡®√‘≠ππ∑å ¿“§«‘™“‡¿ —™ ¢π“¥ 250, 500, 750, 1,000, ·≈– 1,250 ‰¡‚§√°√—¡/

«‘π‘®©—¬ §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬¡À‘¥≈ „π ¡‘≈≈‘≈‘μ√) ·μà “√ °—¥·Õ≈°ÕŒÕ≈å¡’ƒ∑∏‘Ϭ—∫¬—È߉¥â
∫∑§«“¡ „∫∑ÿ‡√’¬π‡∑»√—°…“¡–‡√Á߉¥â (®√‘ßÀ√◊Õ).....∑’Ë ‚¥¬¡’§à“ IC = 335.85 ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√
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π’Ë¡’§”μÕ∫ √ÿª«à“ 5. ß“π«‘®—¬¢Õß°√¡«‘∑¬“»“ μ√å°“√·æ∑¬å
1. °“√∑∫∑«π¢âÕ¡Ÿ≈∑“ß«‘∑¬“»“ μ√å∑—Ë«‚≈° æ∫«à“ “√ °—¥πÈ”®“°„∫∑ÿ‡√’¬π‡∑»¡’º≈μàÕ‡´≈≈å
æ∫«à“ ¬—߉¡à¡’¢âÕ¡Ÿ≈°“√»÷°…“„π√–¥—∫§≈‘π‘° ®÷߉¡à¡’ ¡–‡√Áßμ—∫ ‚¥¬¡’º≈¶à“‡´≈≈å¡–‡√Áßμ—∫‰¥â ‚¥¬‡©æ“–

§«“¡√Ÿâ„π°“√„™â√—°…“„π§π πÈ”μâ¡®“°„∫·Àâß à«ππÈ”§—Èπ®“°„∫ ¥¡’º≈‡™àπ
2. “√ °—¥ à«π„À≠à∑’Ë„™â„π°“√«‘®—¬‡ªìπ “√ ‡¥’¬«°—π·μà¡’æ‘…μàÕ‡´≈≈åμ—∫ª°μ‘¥â«¬

°—¥®“°·Õ≈°ÕŒÕ≈å ´÷Ëß¡’ƒ∑∏‘Ϭ—∫¬—È߇´≈≈å¡–‡√Áß · ¥ß«à“ “√ ”§—≠„ππÈ”μâ¡„∫∑ÿ‡√’¬π‡∑»Õ“®
À≈“¬™π‘¥„πÀ≈Õ¥∑¥≈Õß ´÷Ëß “√‡À≈à“π—Èπ§◊Õ “√ ®–‡ªìπ “√°≈ÿà¡ annonaceous acetogenins ∑’Ë
°≈ÿà¡ annonaceous acetogenins, alkaloids, ≈–≈“¬ÕÕ°¡“‰¥â∫â“ߥ⫬πÈ”√âÕπ

styryllactones ´÷Ëß “√¥—ß°≈à“«®–‰¡à∂Ÿ° °—¥ÕÕ°¡“ 6. ß“π«‘®—¬®”π«π¡“°∑’Ë»÷°…“„π “√ °—¥
¥â«¬πÈ” ·Õ≈°ÕŒÕ≈å¢Õß„∫∑ÿ‡√’¬π‡∑» (À√◊Õ√Ÿª·∫∫¬“∑‘߇®Õ√å
3. ®“°ß“π«‘®—¬¢Õß Champy ·≈–§≥– À√◊Õ¬“¥Õß) æ∫«à“ “√ª√–°Õ∫∑“߇§¡’ à«π„À≠à∑’Ë

(2005) æ∫«à“ “√ annonacin „π‡π◊ÈÕº≈ ™“™ß πÈ” æ∫„π “√ °—¥·Õ≈°ÕŒÕ≈宓°„∫ §◊Õ “√°≈ÿà¡
μâ¡ ·≈– “√ °—¥‡¡∑“πÕ≈®“°„∫ “√ annonacin annonaceous acetogenins ·≈– “√°≈ÿà¡
®–∂Ÿ° °—¥ÕÕ°¡“„π√Ÿª·∫∫™“™ß ·≈–πÈ”μ⡉¥âπâÕ¬ isoquinoline alkaloids ´÷Ëß “√°≈ÿà¡ annonaceous

°«à“‡π◊ÈÕº≈ ª√–¡“≥ 100 ‡∑à“ ·≈–°“√∑’Ë “√ acetogenins ∑’Ë °—¥‰¥â®“° à«π„∫¡’¡“°°«à“ 30 ™π‘¥
annonacin ∂Ÿ° °—¥ÕÕ°¡“‰¥â¥â«¬πÈ”√âÕπ ‡π◊ËÕß “√‡À≈à“π—Èπ‡ªìπ “√∑’Ë¡’ƒ∑∏‘Ϭ—∫¬—È߇´≈≈å¡–‡√Áß∑—Èß„π
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®“° “√π’È¡’®ÿ¥À≈Õ¡μ—«μË” (ª√–¡“≥ 64 C) ®“°ß“π À≈Õ¥∑¥≈Õß·≈– —μ«å∑¥≈Õß
«‘®—¬¢Õß Fidianingsih ·≈–§≥– (2014) ‰¥âº≈ °“√»÷°…“„πÀ≈Õ¥∑¥≈Õß æ∫«à“ “√ °—¥
π—∫ πÿπ«à“™“™ß„∫∑ÿ‡√’¬π‡∑» ¡’ƒ∑∏‘χªìπæ‘…μàÕ‡´≈≈å ethyl acetate ¡’ƒ∑∏‘Ï„π°“√¬—∫¬—Èß°“√‡®√‘≠¢Õß

¡–‡√Á߇μâ“π¡™π‘¥ T47D ‰¥â∫â“ß ·μàπâÕ¬°«à“ “√ ‡´≈≈å¡–‡√Áߪե™π‘¥ A549 ‰¥â¥’∑’Ë ÿ¥ ‚¥¬¡’°≈‰°
¡“μ√∞“π tamoxifen 274 ‡∑à“ (¡’§à“ IC = À¬ÿ¥¬—Èß°“√·∫àßμ—«¢Õ߇´≈≈å (cell cycle arrest)
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31,384.21 ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√ à«π “√ tamoxifen ·≈–∑”„À⇴≈≈å쓬·∫∫ apoptosis ‚¥¬ºà“π
¡’§à“ IC = 114.52 ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√) · ¥ß«à“ °√–∫«π°“√ mitochondrial-mediated signalling
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