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„π√à“ß°“¬) ‚¥¬„Àâ “√ °—¥¢¡‘Èπ™—π∑“ߪ“°‡ªìπ‡«≈“ ‡§Õ√姟¡‘π (curcumin) ¥’‡¡∑Õ°´’‡§Õ√姟¡‘π
5 «—π°àÕπ°“√„À⇥Á°´“‡¡∑“‚´π ·≈–„Àâæ√âÕ¡°—∫ (demethoxycurcumin) ·≈– ∫’ ¥’‡¡∑Õ°´’‡§Õ√å-

‡¥Á°´“‡¡∑“‚´πÕ’°‡ªìπ‡«≈“ 21 «—π æ∫«à“ “√ °—¥ §Ÿ¡‘π (bismethoxycurcumin) ´÷Ëß®“°°“√»÷°…“æ∫
¢¡‘Èπ™—π™à«¬≈¥°“√쓬¢Õ߇´≈≈åª√– “∑„π ¡Õß «à“ “√‡§Õ√姟¡‘πÕ¬¥å ¡’ƒ∑∏‘Ï∑“߇¿ —™«‘∑¬“À≈“¬Õ¬à“ß
à«πŒ‘ª‚ª·§¡ªí ‰¥â ·μà‰¡à “¡“√∂≈¥°“√쓬¢Õß ‰¥â·°à μâ“πÕÕ°´‘‡¥™—π (Anti-oxidation) ·≈–

‡´≈≈å π—∫ πÿπ·Õ ‚∑√‰´μå (astrocyte) °“√»÷°…“ μâ“π°“√Õ—°‡ ∫ (Anti-inflammation) ‡ªìπμâπ ∑’Ë
π’È· ¥ß„Àâ‡ÀÁπ«à“ “√ °—¥¢¡‘Èπ™—πÕ“®™à«¬ª°ªÑÕß ”§—≠ §◊Õ “¡“√∂¬—∫¬—Èß “√‰´‚쉧πå∑’Ë π—∫ πÿπ
‡´≈≈åª√– “∑„π ¡Õß à«πŒ‘ª‚ª·§¡ªí ∑’ˇ ◊ËÕ¡ °“√Õ—°‡ ∫ (Proinflammatory cytokines) „π°“√

®“°¿“«–§«“¡‡§√’¬¥‰¥â ‚¥¬Õ“®‡°‘¥®“°ƒ∑∏‘Ïμâ“π ºà“μ—¥∫“¬æ“ À—«„®·≈–ªÕ¥ (Cardiopulmonary
ÕÕ°´‘‡¥™—π¢Õß “√ °—¥π’È bypass) ·≈–™à«¬≈¥°“√쓬·∫∫Õ–æÕæ‚∑´’
(apoptosis) ¢Õ߇´≈≈å°≈â“¡‡π◊ÈÕÀ—«„®„π —μ«å
Acharaporn Issuriya, Ekkasit Kumarnsit, Chatchai
∑¥≈Õß∑’ËÀ—«„®¢“¥‡≈◊Õ¥ πÕ°®“°π’Ȭ—ßæ∫«à“ “¡“√∂
Wattanapiromsakul, Uraporn Vongvatcharanon.
≈¥°“√쓬·∫∫‡π‚§√´’ (necrosis) ¢Õß°≈â“¡‡π◊ÈÕ
Histological studies of neuroprotective effects of
Curcuma longa Linn. on neuronal loss induced À—«„®¢ÕßÀπŸ·√∑∑’ˉ¥â√—∫ “√‰Õ‚´‚ª√‡∑Õ√‘πÕ≈ (iso-
by dexamethasone treatment in the rat hippoc-
proterenol) ¥—ßπ—ÈπºŸâ«‘®—¬®÷ß∑”°“√»÷°…“º≈¢Õß
ampus. Acta Histochemica. 2014;116:1443-53.
“√‡§Õ√姟¡‘πÕ¬¥å„π°“√¬—∫¬—Èß°“√쓬¢Õß°≈â“¡-
‡π◊ÈÕÀ—«„® (myocardial infraction) ®“°°“√¢“¥‡≈◊Õ¥

“√‡§Õ√姟¡‘πÕ¬¥å (Curcuminoids) ®“°¢¡‘Èπ „πºŸâªÉ«¬ºà“μ—¥∑”∫“¬æ“ ¢ÕßÀ≈Õ¥‡≈◊Õ¥À—«„®
™—π ™à«¬≈¥§«“¡∂’Ë„π°“√‡°‘¥°≈â“¡‡π◊ÈÕÀ—«„® ‚§‚√π“√’ (Coronary Artery Bypass Grafting)

쓬‡©’¬∫æ≈—π„πºŸâªÉ«¬ºà“μ—¥∑”∫“¬æ“ ¢Õß ‚¥¬»÷°…“„πºŸâªÉ«¬ 121 √“¬ ·∫à߇ªìπ 2 °≈ÿà¡ °≈ÿà¡
À≈Õ¥‡≈◊Õ¥À—«„®‚§‚√π“√’ ∑’ˉ¥â√—∫ “√‡§Õ√姟¡‘πÕ¬¥å 61 √“¬ °≈ÿà¡∑’ˉ¥â√—∫¬“
À≈Õ° (placebo) 60 √“¬ æ∫«à“ “√‡§Õ√姟¡‘πÕ¬¥å
†
«√√≥«√“ß§å «ß»å‡®√‘≠*, »»‘«‘¡≈ „®‡Õ◊ÈÕ , Õ√‘π∑¬“
“¡“√∂≈¥°“√‡¢â“√—°…“μ—«„π‚√ß欓∫“≈¢ÕߺŸâªÉ«¬
æ√À¡‘π∏‘°ÿ≈*, «’√–™—¬ π“«“√«ß»å*, ÿ√‘π∑√å «√°‘®
®“°¿“«–À—«„®¢“¥‡≈◊Õ¥‰¥â ®“° 30% „π¬“À≈Õ°
æŸπº≈*, ∏‘μ‘æß…å ‡∑æ ÿ«√√≥*, Õ¿‘™“μ ÿ§π∏
‡À≈◊Õ‡æ’¬ß 13.1% „π°≈ÿࡉ¥â√—∫ “√‡§Õ√姟¡‘πÕ¬¥å
√√æå*, ≥—∞¬“¿√≥å Õ¿—¬„®*, π‘æπ∏å ©—μ√∑‘æ“°√*
πÕ°®“°π’Ȭ—ßæ∫«à“ “√∑’ˇ°’ˬ«°—∫°“√Õ—°‡ ∫ (inflam-
* §≥–·æ∑¬»“ μ√å ¡À“«‘∑¬“≈—¬‡™’¬ß„À¡à
mation) ·≈–§«“¡‡§√’¬¥ÕÕ°´‘‡¥™—π (oxidative
†
‚√ß欓∫“≈‡™’¬ß√“¬ª√–™“πÿ°Ÿ≈ ®—ßÀ«—¥‡™’¬ß√“¬
stress) ‡™àπ C-reactive protein, malondial-
American Journal of Cardiology. 2012;110:40-
dehyde, and N-terminal pro-B-type natriuretic
4.
peptide °Á≈¥μË”°«à“‡¡◊ËÕ‡∑’¬∫°—∫°≈ÿ࡬“À≈Õ° ´÷Ëß
“√‡§Õ√姟¡‘πÕ¬¥å (Curcuminoids) ®“°¢¡‘Èπ ®“°°“√»÷°…“π’È· ¥ß„Àâ‡ÀÁπ«à“ “√‡§Õ√姟¡‘πÕ¬¥å
™—π (Curcuma longa Linn.) ¡’À≈“¬™π‘¥ ‰¥â·°à “¡“√∂≈¥°“√‡°‘¥°≈â“¡‡π◊ÈÕÀ—«„®μ“¬‡©’¬∫æ≈—π