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ÕÕ°‰´¥å ‚¥¬ºà“π∑“ß ‡ÕÁπ‡Õø-·§ªª“∫’ (NF-kB) μ–«—πÕÕ°‡©’¬ß‡Àπ◊Õ ‚¥¬π”¡“ª√–°Õ∫Õ“À“√ ·≈–
√«¡∑—È߬—ß°√–μÿâπ°“√· ¥ßÕÕ°¢Õ߬’π∑’Ë √â“߇ÕÁπ ¬—ß¡’°“√„™â∑“ß°“√·æ∑¬åæ◊Èπ∫â“π‡ªì𬓷°â‚√§≈¡

‰´¡åŒ’¡ÕÕ°´‘‡®‡π -1 (heme oxygenase-1) ∑—Èß ·°â摅ߟ·≈–æ‘…·¡≈ߪÉÕß ®“°°“√»÷°…“æ∫«à“ “√
„π√–¥—∫‡ÕÁ¡Õ“√å‡ÕÁπ‡Õ (mRNA) ·≈–‚ª√μ’π ´÷Ëß °—¥®“°‡ÀÁ¥≈¡·≈– “√ °—¥À¬“∫‚æ≈’·´§§“‰≈¥å
ƒ∑∏‘Ï¢Õß “√ °—¥‡æ™√ —߶“μ„π°“√¬—∫¬—Èß°“√ √â“ß ®“°‡ÀÁ¥≈¡¡’ƒ∑∏‘Ïμâ“πÕÕ°´‘‡¥™—π ¬—∫¬—Èß°“√¢¬“¬

‰πμ√‘°ÕÕ°‰´¥å (NO) ∂Ÿ°¬—∫¬—È߉¥â¥â«¬ “√¬—∫¬—Èß μ—«¢Õ߇´≈≈å¡–‡√Á߇μâ“π¡‡æ“–‡≈’È¬ß πÕ°®“°π’È “√
‡ÕÁπ‰´¡åŒ’¡ÕÕ°´‘‡®‡π -1 ´÷Ëߺ≈°“√»÷°…“π’ș૬ °—¥∫√‘ ÿ∑∏‘Ï®“°‡ÀÁ¥≈¡∫“ßμ—«¬—ß¡’ƒ∑∏‘Ï¥â“πŒÕ√å‚¡π
¬◊π¬—πƒ∑∏‘Ï·≈–· ¥ß∂÷ß°≈‰°°“√ÕÕ°ƒ∑∏‘Ïμâ“π°“√ ‡Õ ‚μ√‡®π ‡ªìπμâπ ®“°°“√∑’Ë¡’°“√„™â‡ÀÁ¥≈¡„π°“√

Õ—°‡ ∫¢Õß “√ °—¥‡æ™√ —߶“μ ·°â‰¢â·≈–≈¥°“√Õ—°‡ ∫„π∑“ß°“√·æ∑¬åæ◊Èπ∫â“π ºŸâ
«‘®—¬®÷ß π„®∑’Ë®–»÷°…“‡æ◊ËÕ¬◊π¬—πƒ∑∏‘Ïπ’È∑—Èß°“√
*Klaokwan Srisook, Mullika Palachot, Nadtaya
∑¥≈Õß·∫∫„𰓬 (in vivo) „π°“√ÀπŸ·√∑·≈–·∫∫
Mongkol, Ekaruth Srisook, Songklod Sarapusita.
πÕ°°“¬ (in vitro) „π‡´≈≈凡Á¥‡≈◊Õ¥¢“«¡“‚§√ø“®
Anti-inflammatory effect of ethyl acetate extract
from Cissus quadrangularis Linn. may be (Macrophage) ‡æ“–‡≈’È¬ß ´÷Ëߺ≈°“√»÷°…“°Áæ∫«à“
involved with induction of heme oxygenase-1 and
“√ °—¥‡ÀÁ¥≈¡ “¡“√∂¬—∫¬—Èß°“√Õ—°‡ ∫∑’ËÕÿâ߇∑â“ÀπŸ
suppression of NF-β activation. Journal of
Ethnopharmacology 2011;133:1008-14. ·√∑∑’Ë∂Ÿ°∑”„ÀâÕ—°‡ ∫‰¥â ®“°°“√»÷°…“πÕ°°“¬°Á

æ∫«à“ “√ °—¥‡ÀÁ¥≈¡‡ªìπæ‘…μàÕ‡´≈≈å¡“‚§√ø“®
‡æ“–‡≈’È¬ß ·≈–¡’ƒ∑∏‘Ϭ—∫¬—Èß°“√ √â“߉πμ√‘°ÕÕ°‰´¥å
“√ °—¥®“°‡ÀÁ¥≈¡ (Lentinus polychrous)
-
·≈– “√Õπÿ¡Ÿ≈ÕÕ°´‘‡®π (O ) „π‡´≈≈å “√ °—¥‡ÀÁ¥
2
™à«¬≈¥Õ“°“√Õ—°‡ ∫„π°“√»÷°…“πÕ°°“¬
≈¡¬—߬—∫¬—Èß°“√· ¥ßÕÕ°¢Õß “√∑’ˇ°’ˬ«¢âÕß°—∫°“√
·≈–„πÀπŸ·√∑*
Õ—°‡ ∫ ‰¥â·°à ‡ÕÁπ‰´¡å‰πμ√‘°ÕÕ°‰´¥å´‘π‡∑ (iNOS)
†
π‘√“¡—¬ Ω“ß°√–‚∑°*, , ®‘πμπ“ ®ÿ≈∑—»πå*, ∫—ßÕ√ Õ‘π‡μÕ√å≈‘«§’π-1 ‡∫μâ“ (IL-1beta) Õ‘π‡μÕ√å≈‘«§’π-6
»√’æ“π‘™°ÿ≈™—¬* (IL-6) ∑’‡ÕÁπ‡Õø-·Õ≈ø“ (TNF-alpha) ·≈– ‰´
*»Ÿπ¬å«‘®—¬·≈–æ—≤π“º≈‘μ¿—≥±å ÿ¢¿“殓° ¡ÿπ‰æ√ ‚§≈ÕÕ°´‘‡®‡π -2 (COX-2) ‡ªìπμâπ ´÷Ëߺ≈°“√
§≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬¢Õπ·°àπ »÷°…“π’ș૬¬◊π¬—πƒ∑∏‘Ïμâ“π°“√Õ—°‡ ∫¢Õß “√ °—¥
†
§≥–‡∑§‚π‚≈¬’‡°…μ√°√√¡ ¡À“«‘∑¬“≈—¬∫Ÿ√æ“ ‡ÀÁ¥≈¡„π°“√„™â∑“ß°“√·æ∑¬åæ◊Èπ∫â“π
Journal of Ethnopharmacology 2013;147:
*Niramai Fangkrathok, Jintana Junlatat, Bungorn
631-7.
Sripanidkulchai. In vivo and in vitro anti-
inflammatory activity of Lentinus polychrous ex-
‡ÀÁ¥≈¡ (Lentinus polychrous Leveille) ¡’™◊ËÕ
tract. Journal of Ethnopharmacology 2013;147:
Õ◊Ëπ§◊Õ ‡ÀÁ¥°√–¥â“ß À√◊Õ ‡ÀÁ¥∫¥ ‡ªìπ‡ÀÁ¥∑’Ë¢÷Èπμ“¡ 631-7.

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