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Journal of Thai Traditional & Alternative Medicine Vol. 7 No. 2 May-August (Supplement) 2009 Ùı
ƒ∑∏‘ϰ√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π·≈–μâ“π¡–‡√ÁߢÕß “√ °—¥¥Õ°·≈– ªÕ√å‡ÀÁ¥À≈‘π®◊Õ
‚°«‘∑ æ—≤π“ªí≠≠“ —μ¬å, °…¡“ ÿ¢“¿‘√¡¬å, πæ¡“» ÿπ∑√‡®√‘≠ππ∑å
∂“π à߇ √‘¡°“√«‘®—¬ §≥–·æ∑¬»“ μ√廑√‘√“™æ¬“∫“≈ ¡À“«‘∑¬“≈—¬¡À‘¥≈
¿“§«‘™“‡¿ —™«‘π‘®©—¬ §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬¡À‘¥≈
À≈—°°“√·≈–‡Àμÿº≈ ‡ÀÁ¥À≈‘π®◊Õ (Gamoderma lucidum (Fr.) Karst.) ‡ªìπ ¡ÿπ‰æ√®’π∑’Ë¡’°“√„™â„π°“√ √â“߇ √‘¡ ÿ¢¿“æ
ªÑÕß°—π·≈–√—°…“‚√§¡“‡ªìπ‡«≈“π“π ¡’ƒ∑∏‘Ï„π°“√°√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π·≈–μâ“π¡–‡√Áß ·≈–„πª√–‡∑»‰∑¬°Á¡’°“√„™âº≈‘μ¿—≥±å®“°
‡ÀÁ¥À≈‘π®◊Õ°—πÕ¬à“ß·æ√àÀ≈“¬ ∑—Èß„™â„π°“√∫”√ÿß√à“ß°“¬ ‡ √‘¡¿Ÿ¡‘μâ“π∑“π ·≈–„πºŸâªÉ«¬¡–‡√Áß·≈–‚√§Õ◊ËπÊ „πª√–‡∑»‰∑¬¬—ß
‰¡à¡’°“√»÷°…“ƒ∑∏‘Ï„π°“√°√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π·≈–μâ“π¡–‡√Áß
«—μ∂ÿª√– ß§å ‡æ◊ËÕ»÷°…“ƒ∑∏‘Ï„π°“√°√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π·≈–μâ“π¡–‡√ÁߢÕß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿåμà“ßÊ (G2, G5 ·≈–
G9) ∑—Èß∑’Ëπ”‡¢â“®“°ª√–‡∑»®’πÀ√◊Õ¢¬“¬æ—π∏ÿå„πμà“ߪ√–‡∑»
«‘∏’°“√¥”‡π‘π°“√ π” “√ °—¥πÈ”, ·Õ≈°ŒÕ≈≈å¢Õ߇ÀÁ¥À≈‘π®◊Õ ¡“≈–≈“¬„π Phosphate buffered saline ·≈– à«π∑’ˉ¡à
≈–≈“¬πÈ” ≈–≈“¬„ππÈ”‡≈’Ȭ߇´≈≈å∑’Ë¡’ DMSO Ú% ¡“∑”°“√∑¥ Õ∫ƒ∑∏‘Ï„π°“√°√–μÿâπ‡´≈≈å„π√–∫∫¿Ÿ¡‘§ÿâ¡°—π§◊Õ ‡´≈≈凡Á¥
‡≈◊Õ¥¢“«™π‘¥≈‘¡‚ø‰´μå·≈–∑¥ Õ∫º≈μàÕ°“√쓬¢Õ߇´≈≈å·∫∫ apoptosis ¢Õ߇´≈≈å¡–‡√Á߇¡Á¥‡≈◊Õ°¢“«™π‘¥ Jurkat cell line
‚¥¬°“√„™â‡∑§π‘§∑“ß‚ø≈‰´‚μ‡¡∑√’
º≈°“√»÷°…“ °“√«—¥°“√ª√“°Ø¢Õß‚¡‡≈°ÿ≈ CD69 ∫πº‘«‡´≈≈凡Á¥‡≈◊Õ¥¢“«™π‘¥≈‘¡‚ø‰´μåæ∫«à“ “√ °—¥πÈ”·≈– à«π∑’ˉ¡à
≈–≈“¬πÈ”∑’˧«“¡‡¢â¡¢âπ Ò ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√ ®“° ªÕ√å∑’ˬ—߉¡à‰¥â°–‡∑“–‡ª≈◊Õ°¢Õ߇ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿå G9 ´÷Ë߇ªì𠓬
æ—π∏ÿå∑’Ë¡“®“°ª√–‡∑»®’π “¡“√∂°√–μÿâπ„À⇰‘¥°“√μÕ∫ πÕߢÕß∑’≈‘¡‚ø‰´μ剥⥒∑’Ë ÿ¥ „π¢≥–∑’Ë “¬æ—π∏ÿå G2 ´÷Ë߇ªì𠓬æ—π∏ÿå∑’Ë
π”¡“‡æ“–‡≈’Ȭ߷≈–¢¬“¬æ—π∏ÿå„πª√–‡∑»‰∑¬π—Èπ “¡“√∂°√–μÿâπ„À⇰‘¥°“√μÕ∫ πÕ߉¥â‡æ’¬ßª√–¡“≥§√÷ËßÀπ÷Ë߇∑à“π—Èπ‡¡◊ËÕ‡∑’¬∫
°—∫ “¬æ—π∏ÿå G9 ·≈–°“√∑¥ Õ∫º≈μàÕ°“√쓬¢Õ߇´≈≈å·∫∫ apoptosis æ∫«à“ “√ °—¥‰¡à¡’æ‘…μàÕ‡´≈≈å∑’Ë¡’𑫇§≈’¬ ‡¥’¬«¢Õß
§πª°μ‘·≈–‰¡à∑”„À⇴≈≈å¡–‡√Á߇¡Á¥‡≈◊Õ¥¢“«™π‘¥ Jurkat cell line 쓬¥â«¬
¢âÕ √ÿª °“√∑¥ Õ∫ƒ∑∏‘Ï¢Õß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿåμà“ßÊ æ∫«à“ ªÕ√å‡ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿå∑’Ë¡“®“°ª√–‡∑»®’π„Àâ
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