Page 75 - วารสารกรมการแพทย์แผนไทยฯ ปีที่ 5 ฉบับที่ 2 (ฉบับเสริม)
P. 75

๖๗


               OR-33


               „µ¦°°„§š›·Í„µ¦¡µœÊ嘵¨„¨¼Ã‡­Á…oµ­¼nÁލ¨r„¨oµ¤ÁœºÊ°…°Š¡ºŸ´„ÒÓ œ·— ×¥Áž¦¸¥Áš¸¥„´

               ¥µÁ¤š¢°¦r¤·œ

               „»­»¤µ¨¥r œo°¥Ÿµ, ­»ª·–µ ¦´˜œ´¥ªŠ«r
               £µ‡ª·µ¸ªÁª«µ­˜¦r ‡–³Â¡š¥«µ­˜¦r ¤®µª·š¥µ¨´¥­Š…¨µœ‡¦·œš¦r


               ª´˜™»ž¦³­Š‡r Á¡ºÉ°š—­°­¦¦¡‡»–Äœ„µ¦¦´„¬µÃ¦‡Áµ®ªµœ…°Š¡ºŸ´„‹Îµœªœ ÒÓ œ·—Å—o„n ®´ª®°¤
               Ä®n (Allium cepa) ®´ª„¦³Áš¸¥¤ (Allium sativum) ¥°—¤³¤nªŠ®·¤¡µœ˜r (Anacardium occidentale) —°„

               ­³Á—µ (Azadirachta indica) ĝ˜Îµ¨¹Š (Coccinia indica) ˜oœŸ´„¸ (Coriandrum sativum) ĝ„³Á¡¦µ (Ocimum

               sanctum) ¤³¦³‹¸œ (Momordica charantia) ĝ³¡¨¼ (Piper sarmentosum) ª®°¤ (Luffa cylindrica)

               …·ŠÂ„n (Zingiber officinale) ¨³Ä´ª„ (Centella asiatica) ×¥«¹„¬µ„µ¦°°„§š›·Í¡µœÊ嘵¨„¨¼Ã‡­Á…oµ­¼n
               Áލ¨r„¨oµ¤ÁœºÊ°¨µ¥…°Š®œ¼ (L6 myoblast) š¸ÉÁ¡µ³Á¨¸Ê¥ŠÄœ®o°Šž’·´˜·„µ¦

               ª´­—»Â¨³ª·›¸„µ¦ Á¡µ³Á¨¸Ê¥Š L6 myoblasts Ĝ™µ— ÓÕ ®¨»¤‹œ‡¨»¤¡ºÊœš¸É ØÑ-ÙÑ% …°Š®¨»¤Á¡µ³Á¨¸Ê¥ŠÂ¨oªšÎµ

               „µ¦´„œÎµÄ®o ÙÑ-ÚÑ% …°ŠÁލ¨r differentiated Á…oµ­¼n¦³¥³ myotubes ¡¦o°¤š¸É‹³Äo˜¦ª‹ª´—„µ¦°°„§š›·Í¡µ
               œÊ嘵¨Á…oµ­¼nÁލ¨r…°Š­µ¦­„´—œÊε‹µ„Ÿ´„š´ÊŠÒӍœ·—š¸É‡ªµ¤Á…o¤…oœÔ¦³—´ (Ñ.ÑÖ, Ñ.Ó, ¨³ Ò ¤„./¤¨.)

               ×¥Áž¦¸¥Áš¸¥„´¥µš¸ÉčoĜ„µ¦¦´„¬µŸ¼ožiª¥Áµ®ªµœ metformin (2 mM) ×¥ª·›¸¤µ˜¦“µœ (2-[3H]-deoxy-

               D-glucose (2-DG) uptake assay) ­µ¦­„´—š¸É°°„§š›·Í°¥nµŠ¤¸œ´¥­Îµ‡´šµŠ­™·˜·‹³™¼„œÎµ¤µ«¹„¬µ„µ¦°°„§š›·Í
               ĜnªŠÁª¨µ˜nµŠ Ç (Ò, Ó, Õ, Ù¨³ ÓÕ ¤.) ¦ª¤š´ÊŠ„¨Å„Äœ„µ¦°°„§š›·ÍĜÁºÊ°Š˜oœÃ—¥—¼°·š›·¡¨…°Š ­µ¦

               ¥´¥´ÊŠ„µ¦­¦oµŠÃž¦˜¸œ (˜´ª¡µ„¨¼Ã‡­œ·— GLUT-1  ¨³ GLUT-4) ‡º° cycloheximide ¨³­µ¦¥´¥´ÊŠ„µ¦

               šÎµŠµœ…°ŠÁ°ÈœÅޤr PI3-kinase (­µ¦ wortmanin) Ž¹ÉŠ¤¸šµš„¦³˜»oœ„µ¦Á‡¨ºÉ°œš¸É…°Š GLUT-4

               Ÿ¨„µ¦«¹„¬µ Ÿ¨¡ªnµ¤¸Ÿ´„Ó œ·—‡º°®´ª®°¤Ä®n¨³…·Šš¸É­µ¤µ¦™Á¡·É¤¦³—´„µ¦œÎµ„¨¼Ã‡­Á…oµ­¼nÁލ¨r
               „¨oµ¤ÁœºÊ°Å—o°¥nµŠ¤¸œ´¥­Îµ‡´šµŠ­™·˜·ÁnœÁ—¸¥ª„´ metformin Á¤ºÉ°n¤Á¡µ³Áލ¨r„´­µ¦­„´—®°¤Ä®nš¸É‡ªµ¤

               Á…o¤…oœÕ¤„./¤¨., …·Šš¸É Ñ.Õ¤„./¤¨. ¨³ Ó mM  metformin Áž}œÁª¨µ ÓÕ ´ÉªÃ¤Š ¡ªnµ­µ¤µ¦™„¦³˜»oœ

               „µ¦¡µ„¨¼Ã‡­Á…oµ­¼nÁލ¨rŗoÁ¡·É¤…¹ÊœÁž}œÒÙ×.ÖÓ ± ÒÒ.×Ó%, ÒÚØ.ØÓ ±  ÒÔ.×Ö% ¨³ ÓÑÖ.ÚÓ ±

               ×.ÑÓ% ˜µ¤¨Îµ—´ (p<0.05) Á¤ºÉ°Áž¦¸¥Áš¸¥„´„¨»n¤‡ª‡»¤Ž¹ÉЇ·—Áž}œÒÑÑ% „µ¦°°„§š›·Íœ¸Ê­µ¤µ¦™˜¦ª‹
               ¡Å—o®¨´Š‹µ„„µ¦n¤Á¡µ³„´­µ¦­„´—œÊε‹µ„®´ª®°¤Ä®n¨³…·ŠÁž}œÁª¨µ°¥nµŠœo°¥ Õ ´ÉªÃ¤Š ×¥„¦³˜»oœ

               „µ¦¡µ„¨¼Ã‡­Á…oµ­¼nÁލ¨rŗoÁ¡·É¤Áž}œÒÔÔ.ÓÕ ±  Ô.Ô×% ¨³ ÒÖ×.× ±  ×.ÑÑ% ˜µ¤¨Îµ—´ (p<Ñ.ÑÖ)

               „µ¦«¹„¬µ„¨Å„„µ¦°°„§š›·ÍÁºÊ°Š˜oœ¡ªnµ cyclohexamide ­µ¤µ¦™¥´¥´ÊŠ„µ¦°°„§š›·Í…°Š­µ¦­„´—
               ®´ª®°¤Ä®nŗo°¥nµŠ­¤¼¦–r (‹µ„ ÒÚÒ.ÙÕ ± ÒÙ.ÓÒ% ¨—Á®¨º°ÕÕ.ÓÕ ± Ó.ÙÕ%) Ĝ…–³š¸É¥´¥´ÊŠ„µ¦

               „µ¦°°„§š›·Í‹µ„…·ŠÅ—oÁ¡¸¥Š ÕÔ.Ø% (‹µ„ ÓÑ×.ÓÚ ± ÓÓ.ÚÓ% ¨—Á®¨º° ÒÒ×.ÑÖ ± ÒÒ.ÙÙ%) Ĝ…–³

               š¸É wortmanin ¥´¥´ÊŠ„µ¦°°„§š›·Í…°Š­µ¦­„´—š´ÊŠ­°Šœ·—Å—oÁ¨È„œo°¥ ˜nŤn¤¸œ´¥­Îµ‡´šµŠ­™·˜·
               …o°­¦»ž ®´ª®°¤Ä®nœnµ‹³°°„§š›·Í¡µœÊ嘵¨Á…oµ­¼nÁލ¨rÁ¡µ³Á¨¸Ê¥Š„¨oµ¤ÁœºÊ°Ã—¥°µ«´¥„µ¦Á¡·É¤ž¦·¤µ–

               Þ¦˜¸œ…°Š˜´ª¡µ„¨¼Ã‡­Á¡¸¥Š°¥nµŠÁ—¸¥ª Ĝ…–³š¸É…·Š°°„§š›·ÍŸnµœ„¨Å„šµŠ—oµœ°ºÉœÇš¸Éœ°„Á®œº°‹µ„„µ¦

               Á¡·É¤ž¦·¤µ–Þ¦˜¸œ…°Š˜´ª¡µ„¨¼Ã‡­ Ž¹ÉŠ‹ÎµÁž}œ˜o°ŠšÎµ„µ¦«¹„¬µ¡·­¼‹œr˜n°Åž
   70   71   72   73   74   75   76   77   78   79   80