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             ∑”„À⇰‘¥°“√쓬·∫∫ apoptosis ‚¥¬æ∫«à“°≈‰°   √“¬ß“π°“√‡°‘¥μ—∫«“¬„πºŸâ∑’Ë„™â¬“π’È ·μà°≈‰°°“√

             À≈—°∑’Ë∑”„À⇰‘¥§«“¡‡ªìπæ‘…μàÕ‡´≈≈å¡“®“°°“√  ‡°‘¥μ—∫Õ—°‡ ∫¬—߉¡à∑√“∫ ¡’°“√π”·§ª´Ÿ≈¢’ȇÀ≈Á°‰ª
             ∑”„À⇰‘¥  “√Õπÿ¡Ÿ≈Õ‘ √– (Reactive oxygen   ∑¥ Õ∫„πÀπŸ«‘ μâ“√å æ∫«à“∑”„Àâμ—∫‡ ◊ËÕ¡·≈–‡πà“

             species, ROS) °“√„Àâ “√μâ“πÕπÿ¡Ÿ≈Õ‘ √–°àÕπ®–  ·≈–°“√‡°‘¥æ‘…°—∫μ—∫ —¡æ—π∏å°—∫¢π“¥¬“ ‚¥¬
             ™à«¬≈¥§«“¡‡ªìπæ‘…μàÕ‡´≈≈å¢Õß “√ barakol ‰¥â   “‡Àμÿ°“√‡°‘¥μ—∫Õ—°‡ ∫πà“®–‡°‘¥®“° “√ barakol
             ß“π«‘®—¬π’È∑”„Àâ∑√“∫∂÷ß°≈‰°§«“¡‡ªìπæ‘…μàÕ   ´÷Ë߇ªìπ “√ ”§—≠∑”„ÀâπÕπÀ≈—∫·≈–§≈“¬°—ß«≈

             ‡´≈≈å¢Õß “√ barakol  ´÷ËßÕ“® àߺ≈„À⇰‘¥æ‘…  °“√»÷°…“π’È®÷ß¡’«—μ∂ÿª√– ß§å‡æ◊ËÕ«—¥ª√‘¡“≥ “√
             ¢÷Èπ‰¥â‡¡◊ËÕ‡¢â“ Ÿà√à“ß°“¬„π¢π“¥ Ÿß À√◊Õ„™â‡ªìπ‡«≈“π“π  barakol ‚¥¬«‘∏’ TLC (Thin Layer Chromatog-

                                                         raphy) densitometric method ‚¥¬°“√»÷°…“π’È
             *Wongtongtair S, Chanvorachote P, Hutamekalin  ‡≈’¬π·∫∫°“√„™â¢’ȇÀ≈Á°‡ªìπÕ“À“√¢Õߧπ‰∑¬ ∑’Ë¡’
             P, Chaichantipyuth C, Lipipun V, Tiensiwakul P,
                                                         °“√μâ¡„∫·≈–¥Õ°ÕàÕπ ¥¥â«¬πÈ” 2-3 §√—Èß ‡æ◊ËÕ≈¥
             et al. Barakol-induced apoptosis in P19 cells
             through generation of reactive oxygen species  §«“¡¢¡¢Õߢ’ȇÀ≈Á° ·≈â«®÷ßπ”¡“ª√ÿ߇ªìπ·°ß¢’ȇÀ≈Á°
             and activation of caspase-9. Journal of
                                                         æ∫«à“ „∫ÕàÕπ¡’ barakol 0.4035%  à«ππÈ”∑’ˉ¥â®“°
             Ethnopharmacology. 2011;137:971-8.
                                                         °“√μ⡧√—Èß∑’Ë 1 ·≈– 2 ¡’ª√‘¡“≥ barakol 0.2052

                                                         ·≈– 0.1079% ¢ÕßπÈ”Àπ—°„∫ ¥μ“¡≈”¥—∫  à«π„∫
              ª√‘¡“≥∫“√“§Õ≈„π„∫¢’ȇÀ≈Á° ¥·≈–„∫∑’˺à“π
                                                         ∑’˺à“π°“√μ⡧√—Èß∑’Ë 1 ·≈– 2 ¡’ª√‘¡“≥ barakol
              °“√μâ¡*
                                                         0.1408 ·≈– 0.0414% ¢ÕßπÈ”Àπ—°„∫ ¥μ“¡≈”¥—∫
             Tanit Padumanonda, Wandee Gritsanapan
                                                         °√–∫«π°“√μâ¡¢’ȇÀ≈Á° Õߧ√—Èß∑”„Àâª√‘¡“≥ barakol
             Faculty of Pharmacy, Mahidol University, Bangkok
                                                         ≈¥≈ß∂÷ß 90% ª√‘¡“≥ barakol „π„∫∑’˺à“π°“√μâ¡
             10400, Thailand
                                                         §√—Èß∑’Ë 2 ∑’Ëæ√âÕ¡π”‰ªª√ÿ߇ªìπ·°ß ¡’‡æ’¬ß 10%
             Southeast Asian J Trop med Public Health.
                                                         ¢Õß„∫ ¥ „π 1 ¡◊ÈÕ¢Õß°“√∫√‘‚¿§·°ß¢’ȇÀ≈Á°§“¥«à“
             2006;37(2):388-93.
                                                         Àπ÷Ëß§π®–‰¥â√—∫ barakol 1.25 ¡°. ´÷ËßπâÕ¬°«à“°“√
                                                         ∫√‘‚¿§¢’ȇÀ≈Á°·§ª´Ÿ≈ (2-4 ·§ª´Ÿ≈/§√—Èß) ∂÷ß 16-32
                 ¢’ȇÀ≈Á° (Senna siamea (Lam.) Irwin &
                                                         ‡∑à“ °“√«‘®—¬π’ș૬¬◊π¬—π«à“‡Àμÿ„¥°“√∫√‘‚¿§·°ß¢’È
             Barneby À√◊Õ Cassia siamea) ‡ªìπ ¡ÿπ‰æ√∑’Ë¡’
                                                         ‡À≈Á°®÷߉¡à°àÕ„À⇰‘¥μ—∫Õ—°‡ ∫‡À¡◊Õπ°—∫¢’ȇÀ≈Á°
             °“√„™âÕ¬à“ß·æ√àÀ≈“¬„πª√–‡∑»‰∑¬ §π‰∑¬
                                                         ·§ª´Ÿ≈
             ∫√‘‚¿§„∫·≈–¥Õ°ÕàÕπ¢Õߢ’ȇÀ≈Á°‡ªìπÕ“À“√¡“™â“
                                                         *Padumanonda T, Gritsanapan W. Barakol con-
             π“π ®“°°“√«‘®—¬æ∫»—°¬¿“æ¢Õß„∫¢’ȇÀ≈Á°„π°“√
                                                         tents in fresh and cooked Senna siamea leaves.
             ∫√√‡∑“Õ“°“√πÕπ‰¡àÀ≈—∫ ·μàμàÕ¡“„πªï 2546 ¬“¢’È
                                                         Southeast Asian J Trop med Public Health.
             ‡À≈Á° (∑’ˇªì𬓇¥’ˬ«) ∂Ÿ°∂Õπ∑–‡∫’¬π‡π◊ËÕß®“°¡’  2006;37(2):388-93.
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