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86   «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ°          ªï∑’Ë 12 ©∫—∫∑’Ë 1 ¡°√“§¡-‡¡…“¬π 2557



                                                                       2,3
                                                        πâÕ¬ √ ‡ºÁ¥ª√à“‡¬Áπ
             æ‘¡‡ π ( —߇§√“–Àå) (PIMSEN)
             (SYNTHETIC)                                «‘∏’°“√‡μ√’¬¡


             Borneolum Syntheticum                           æ‘¡‡ π ( —߇§√“–Àå) ‡μ√’¬¡‰¥â®“°ªØ‘°‘√‘¬“
             Synthetic Borneo Camphor                   √’¥—°™—π (reduction) ¢Õß°“√∫Ÿ√ (dl-camphor) ‰¥â
                  æ‘¡‡ π ( —߇§√“–Àå) ‰¥â®“°ªØ‘°‘√‘¬“√’¥—°™—π  ‡ªìπ dl-borneol ´÷Ë߇ªìπ¢Õߺ ¡·√´’¡‘° (racemic

             (reduction) ¢Õß°“√∫Ÿ√ (dl-camphor) ‡ªìπæ‘¡‡ π  mixture) 2
             (dl-borneol) ´÷Ë߇ªìπ¢Õߺ ¡·√´’¡‘° (racemic mix-  ¢âÕ∫àß„™â ·°â≈¡«‘߇«’¬π, ∫√√‡∑“Õ“°“√ª«¥
                 1-4
             ture)                                      ‡¡◊ËÕ¬ ·≈–·¡≈ß°—¥μàÕ¬ „™â‡ªìπ “√·μàß°≈‘Ëπ„𬓷≈–
                  ™◊ËÕÕ◊Ëπ ªî߇æ’ˬπ, æ√¡‡ π, æ‘¡‡ π‡°≈Á¥, ¿‘¡  Õ“À“√ 8,9
                                      2-5
             ‡ π, ¿’¡‡ π, Borneo camphor                     μ”√“ √√æ§ÿ≥¬“‰∑¬«à“ æ‘¡‡ π¡’√ ‡ºÁ¥ª√à“
                  ™◊ËÕ‡§¡’ (1R, 2S, 4R)-rel-1,7,7-trimethyl-  ‡¬Áπ ™à«¬°√–®“¬≈¡∑—Èߪ«ß ∑”„Àâ‡√Õ·≈–º“¬≈¡

             bicyclo [2.2.1] heptan-2-ol; endo-1,7,7-   ·°âÕ“°“√®ÿ°‡ ’¬¥·πàπ‡øÑÕ ·°âÕ“°“√ª«¥∑âÕß „™â
             trimethylbicyclo [2.2.1] heptan-2-ol; bornyl  ‡ªìπ¬“¢—∫‡ ¡À– ¢—∫‡Àß◊ËÕ ·°â≈¡«‘߇«’¬π Àπâ“¡◊¥
                                       2,6,7
             alcohol (±)-borneol, dl-borneol            ∫”√ÿßÀ—«„® 10-12 „™â¿“¬πÕ°‡ªìπ¬“√—°…“·º≈ ¥
                   ¡∫—μ‘∑“߇§¡’ æ‘¡‡ π‡ªìπ “√ª√–°Õ∫     À√◊Õ·º≈‡√◊ÈÕ√—ß 10
             Õ‘π∑√’¬å ª√–‡¿∑¡Õ‚π‡∑Õ√åæ’π·Õ≈°ÕŒÕ≈å (monot-    ¢âÕ§«√√–«—ß §«√„™â¥â«¬§«“¡√–¡—¥√–«—ß„π
             erpene alcohol) ‡≈¢∑–‡∫’¬π CAS 507-70-0 ¡’   μ√’√–À«à“ßμ—Èߧ√√¿å 5

              Ÿμ√‚¡‡≈°ÿ≈ C H O πÈ”Àπ—°‚¡‡≈°ÿ≈ 154.24 §à“
                         10 18                               ¢π“¥·≈–«‘∏’„™â „™âº ¡„πμ”√—∫¬“¥¡·≈–¬“
                                                                                           5
             §«“¡∂à«ß®”‡æ“– 1.011 ®ÿ¥À≈Õ¡‡À≈« 208 Õß»“  „™â¿“¬πÕ° „π¢π“¥·≈–§«“¡‡¢â¡¢âπμà“ßÊ °—π
             ‡´≈‡´’¬  æ‘¡‡ π∫√‘ ÿ∑∏‘Ï®–‡ªìπ·ºàπº≈÷°√ŸªÀ°‡À≈’ˬ¡  À¡“¬‡Àμÿ

             ‡¡◊ËÕ∑‘È߉«â„πÕ“°“»®–√–‡À‘¥‰¥â ≈–≈“¬πÈ”¬“° æ‘¡‡ π  1. §«√‡°Á∫æ‘¡‡ π‰«â„π¿“™π–ªî¥ π‘∑ ∑’Ë
             1  à«π≈–≈“¬‰¥â„πªî‚μ√‡≈’¬¡Õ’‡∑Õ√å (petroleum  Õÿ≥À¿Ÿ¡‘‰¡à‡°‘π 25 Õß»“‡´≈‡´’¬ 
                                                 2,6,7
             ether) 6  à«π À√◊Õ„π‡∫π´‘π (benzene) 5  à«π     2. μ”√“¬“¢Õߪ√–‡∑» “∏“√≥√—∞ª√–™“™π
                                                        ®’π«à“ æ‘¡‡ π‡ªì𬓰√–μÿâπ„Àâ√Ÿâ ÷°μ—«‡¡◊ËÕÀ¡¥ μ‘
                                                        À√◊Õ™—°®“°‰¢â ŸßÀ√◊Õ‡ªìπ≈¡ ∑”„Àâ ¥™◊Ëπ ª≈Õ¥‚ª√àß

                                                        „™â∫√√‡∑“Õ“°“√μ“Õ—°‡ ∫ √—°…“·º≈„π™àÕߪ“°
                                                                                        5
                                                        ≈¥Õ“°“√‡®Á∫§Õ „™â¿“¬πÕ°‡ªìπ¬“∑“·º≈


                                                        ‡Õ° “√Õâ“ßÕ‘ß
                    ·≈–Õ’·ππ∑‘‚Õ‡¡Õ√å (enantiomer)
                                                          1. Youngken HW. Textbook of pharmacognosy, 6th ed.
                  ≈—°…≥–‡§√◊ËÕ߬“ æ‘¡‡ π‡ªìπ‡°≈Á¥‡≈Á° Ê  ’
                                                            Philadelphia: The Blakiston Company; 1948. p. 377.
             ¢“«¢ÿàπÀ√◊Õ„ ‰¡à¡’ ’ °≈‘ËπÀÕ¡‡¬Áπ‡©æ“–μ—« ©ÿπ‡≈Á°  2. The Merck Index, 12th ed. Whitehouse Station (NJ): Merck
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