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Clinical Study of Chanta-lee-la Herbal Household Remedy
1,2
3
1
4
Chayan Picheansoonthon , Thanakorn Wiwek , Benjaluck Phonrat , Prateep Maekprasarn ,
Punnee Pitisuttithum 4,5
1 Pharmaceutical Botany and Pharmacognosy Unit, Faculty of Pharmaceutical Sciences, Khon Kaen University,
Khon Kaen 40002
2 The Academy of Science, The Royal Institute of Thailand, Sanam Suea Pa, Khet Dusit, Bangkok 10300
3 Phu Khiew Hospital, Amphoe Phu Khiew, Chaiyapum 36110
4 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Khet Phyathai, Bangkok
10400
5 Corresponding author
Chanta-lee-la, one of the famous Thai traditional herbal formulas, consists of nine herbs: Kot So [An-
gelica dahurica Benth.], Kot Kamao [Atractylodes lancea (Thunb.)DC.], Kot Chula-lumpa [Artemisia annua
L.], Kadom [(Gymnopetalum cochichinense (Lour.) Kurz], Chanthet [Santalum album L.], Chandaeng
[Pterocarpus santalinus L.f.], Boraphet [Tinospora crispa (L.) Miers ex Hook.f.&Thoms.] and Phalai Phueak
[Eurycoma longifolia Jack], four parts each, and a part of Phimsen (Borneo camphor). Although this remedy
is commonly used as an antipyretic drug at doses of 500 mg to 1 gram every four hours, the clinical trial for
effective fever clearance and safety profile has not yet been done. This research was a prospective study in
patients with the common cold who had met the eligibility inclusion/exclusion criteria. Eighteen patients were
enrolled, with a mean oral temperature before being given the medication, of 38.7˚C 0.7. Follow-up at 4
hours later found the mean oral temperature to be 38.4˚C 0.8 and found decreased to no fever statistically
significant levels when compared with hour 0 and hour 16 with a mean oral temperature of 37.4˚C 0.8 (p <
0.001). Even though this study indicated decreased fever over a longer period of time than drugs currently
used, for safety reasons, the trial herbal recipe did not cause any serious adverse event. The adverse events
that were observed in 77.8 percent of the cases were symptoms related to the common cold.
Key words: clinical trial, Chanta-lee-la, Thai traditional household remedy