Page 137 - วารสารปีที่15ฉบับที่3

403

(Drug interaction) ¥—ßπ—Èπ„π°“√æ—≤π“ “√ °—¥ ¥’ª≈’ “¬æ—π∏ÿå∑’Ëæ∫¡“°„πª√–‡∑»‰∑¬ (Piper chaba

®“°¥’ª≈’¡“„™â‡ªì𬓠À√◊Õ°“√„™â¬“‰∑¬∑’Ë¡’ à«π Hunt.) æ∫«à“¡’ “√·Õ≈§“≈Õ¬¥å ”§—≠ §◊Õ “√™“-
ª√–°Õ∫¢Õߥ’ª≈’®÷ßμâÕ߇æ‘Ë¡§«“¡√–¡—¥√–«—ß„π°“√„™â ∫“‰¡¥å (Chabamide) ¡’ƒ∑∏‘Ï„π°“√μâ“π‡™◊ÈÕ¡“≈“‡√’¬

‡¡◊ËÕ„Àâ√à«¡°—∫¬“·ºπªí®®ÿ∫—π∫“ß™π‘¥∑’Ë∂Ÿ°∑”≈“¬ μâ“π‡™◊ÈÕ«—≥‚√§ ·≈–μâ“π‡´≈≈å¡–‡√Áß„π‡´≈≈å¡–‡√Áß
‚¥¬‡Õπ‰´¡å∑’Ë “√ °—¥®“°¥’ª≈’‰ª¬—∫¬—È߉¥â ‡æ“–‡≈’È¬ß ´÷Ë߇´≈≈å¡–‡√Áß¡—°æ∫¡’ªí≠À“„π°“√¥◊ÈÕ¬“
√—°…“¡–‡√Áß π—°«‘®—¬°≈ÿà¡π’È®÷ß¡’§«“¡ π„®∑’Ë®–
*Sumsakul W, Mahavorasirikul W, Na-Bangchang K.
»÷°…“ƒ∑∏‘Ï·≈–°≈‰°°“√μâ“π‡´≈≈å¡–‡√Á߇¡Á¥‡≈◊Õ¥
Inhibitory Activities of Thai Medicinal Plants with
Promising Activities Against Malaria and ¢“«∑’Ë¥◊ÈÕ¬“ (adriamycin-resistant human leu-
Cholangiocarcinoma on Human Cytochrome P450. kemia cells, K562/ADR) ¢Õß “√™“∫“‰¡¥å®“°
Phytotherapy Research. 2015;29(12):1926-33.
√“°¥’ª≈’ ®“°º≈°“√»÷°…“°Áæ∫«à“ “√™“∫“‰¡¥å
“¡“√∂¬—∫¬—Èß°“√‡®√‘≠ °“√·∫àßμ—« ·≈–∑”„À⇴≈≈å

¡–‡√Áß쓬·∫∫Õ–æÕæ‚∑´’ „π‡´≈≈å¡–‡√Á߇¡Á¥
ƒ∑∏‘Ï·≈–°≈‰°°“√μâ“π‡´≈≈å‡æ“–‡≈’Ȭߡ–‡√Á߇¡Á¥
‡≈◊Õ¥¢“«™π‘¥¥◊ÈÕ¬“π’ȉ¥â ‚¥¬ºŸâ«‘®—¬∑”°“√»÷°…“∂÷ß
‡≈◊Õ¥¢“«¥◊ÈÕ¬“¢Õß “√™“∫“‰¡¥å (Chabamide)
°≈‰°°“√ÕÕ°ƒ∑∏‘Ï„π√–¥—∫‚¡‡≈°ÿ≈¢Õ߃∑∏‘χÀ≈à“π’È
®“°√“°¥’ª≈’ (Piper chaba)*
¢Õß “√™“∫“‰¡¥å¥â«¬ ´÷Ë߇ªìπ¢âÕ¡Ÿ≈æ◊Èπ∞“𠔧—≠
Jie Ren*, Yuanyuan Xu*, Qianhui Huang*,
„π°“√æ—≤π“ “√π’ÈμàÕ‰ª ·μà°Á¬—ßμâÕß∑”°“√»÷°…“
Jie Yang*, Meng Yang*, Kun Hu*, Kun Wei †
‡æ‘Ë¡‡μ‘¡Õ’°¡“°∑—È߃∑∏‘Ï·≈–Õ—πμ√“¬¢Õß “√π’È ‚¥¬
*Department of Pharmaceutical Engineering,
μâÕß»÷°…“∑—Èß·∫∫πÕ°°“¬ (in vitro) ·≈–·∫∫„π
School of Pharmaceutical Engineering and Life
°“¬ —μ«å∑¥≈Õß (in vivo) °àÕπ∑’Ë®–π”¡“»÷°…“∑“ß
Science, Changzhou University, Jiangsu
†
Key Laboratory of Medicinal Chemistry for §≈‘π‘°μàÕ‰ª
Natural Resource, Ministry of Education,
School of Chemical Science and Technology, * Ren J, Xu Y, Huang Q, Yang J, Yang M, Hu K,
Yunnan University, Kunming, Peopleûs Repub- et al. Chabamide induces cell cycle arrest and
lic of China apoptosis by the Akt/MAPK pathway and inhi-
bition of P-glycoprotein in K562/ADR cells. Anti-
Anticancer Drugs. 2015;26(5):498-507.
cancer Drugs. 2015;26(5):498-507.

æ◊™¥’ª≈’ ·æ∑¬å·ºπ‰∑¬·≈–·æ∑¬åæ◊Èπ∫â“π ®–
„™âº≈·°à„π°“√¢—∫≈¡ ·°â∑âÕß√à«ß ™à«¬‡®√‘≠Õ“À“√
ƒ∑∏‘Ïμâ“π¿“«–‡§√’¬¥∑’ˇ°‘¥®“°ÕÕ°´‘‡¥™—π¢Õß
·°âÀ◊¥‰Õ ·°â≈¡«‘߇«’¬π œ≈œ ®“°°“√»÷°…“∑“ß
“√ °—¥®“°º≈¢Õß¡–μŸ¡*
‡¿ —™«‘∑¬“æ∫«à“ “√ °—¥®“°¥’ª≈’™à«¬°√–μÿâπ
Gadham Setty Saayi Krushna*, Mohammed
°≈â“¡‡π◊ÈÕ‡√’¬∫ μâ“π‡™◊ÈÕ·∫§∑’‡√’¬·≈–‡™◊ÈÕ√“∫“ß™π‘¥
†
Abdul Kareem*, Vaddi Damodara Reddy ,
†
πÕ°®“°π’Ȭ—ßæ∫«à“¡’ƒ∑∏‘Ïμâ“π¡“≈“‡√’¬ μâ“π¡–‡√Áß Pannuru Padmavathi , Shaik Althaf Hussain*,
∫“ß™π‘¥ ‚¥¬¡’ºŸâ∑”°“√ °—¥ “√®“°√“°¢Õßμâπ Lakshmi Devi Kodidhela*