Page 148 - วารสารปีที่15ฉบับที่2

273

prenylfuranocoumarins conjugates ™π‘¥Õ◊Ëπ Ê ‡™◊ÈÕ·∫§∑’‡√’¬ 3 ™π‘¥ §◊Õ Porphyromonas

®“°π—Èπ∑”°“√æ‘ Ÿ®πåƒ∑∏‘Ïμâ“π‡Õπ‰´¡å‚§≈‘π‡Õ ‡μÕ‡√ gingivalis, Streptococcus mutans ·≈– Strep-
(cholinesterase) ´÷Ë߇ªìπ‡Õπ‰´¡å¬àÕ¬ ≈“¬ “√ ◊ËÕ tococcus sanguinis ∑’Ë∑”„À⇰‘¥‚√§ª√‘∑—πμ剥⥒

ª√– “∑Õ–´‘∑‘≈‚§≈‘π„π√–∫∫ª√– “∑ ´÷Ëßæ∫«à“ ™à«¬≈¥°“√ √â“߉∫‚Õøî≈塉¥â∂÷ß 99% ·≈– “¡“√∂
“√°≈ÿà¡ 3-O-β-d-glucopyranosyl-3,5,7,4'- ¶à“‡™◊ÈÕ∑—Èß 3 ™π‘¥‰¥â ∂â“„Àâ„𧫓¡‡¢â¡¢âπ‡æ’¬ßæÕ
tetrahydroxy-6,8,3'-trimethoxyflavonol nucleus ·≈–π“πæÕ ‚¥¬∂â“π”¡“º ¡°—∫ “√ chlorhexidine

in the prenylfuranocoumarin-HMGA conju- ∑’Ë„™â„ππÈ”¬“¶à“‡™◊ÈÕ„π™àÕߪ“° ®–¡’°“√‡ √‘¡ƒ∑∏‘Ï„π
gate ¡’ƒ∑∏‘Ï·√ß∑’Ë ÿ¥„π°“√¬—∫¬—È߇Õπ‰´¡å‚§≈‘π‡Õ °“√μâ“π‡™◊ÈÕ·∫§∑’‡√’¬‡æ‘Ë¡¢÷Èπ ”À√—∫°≈‰°°“√ÕÕ°

‡μÕ‡√ ƒ∑∏‘Ïæ∫«à“πÈ”¡—πÀÕ¡√–‡À¬®“°„∫¡–°√Ÿ¥¡’ƒ∑∏‘Ï
∑”≈“¬‡¬◊ËÕÀÿ⡇´≈≈å™—ÈππÕ°¢Õß·∫§∑’‡√’¬ πÕ°®“°
*Seeka C, Sutthivaiyakit P, Youkwan J, Hertkorn
N, Harir M, Schmitt-Kopplin P, et al. π’Ȭ—ß«‘‡§√“–Àåæ∫ “√ÕÕ°ƒ∑∏‘Ï ”§—≠„ππÈ”¡—πÀÕ¡
Prenylfuranocoumarin-HMGA-flavonol glucoside √–‡À¬®“°„∫¡–°√Ÿ¥ §◊Õ “√ citronellal ´÷Ëߺ≈°“√
conjugates and other constituents of the fruit
»÷°…“π’ÈÕ“®π”¡“‡ªìπ¢âÕ¡Ÿ≈æ◊Èπ∞“π‡æ◊ËÕæ—≤π“πÈ”¬“
peels of Citrus hystrix and their anticholinest-
erase activity. Phytochemistry. 2016;127: 38-49. ¶à“‡™◊ÈÕ·∫§∑’‡√’¬∑’Ë∑”„À⇰‘¥‚√§ª√‘∑—πμå„π™àÕߪ“°

∑’Ë¡’πÈ”¡—πÀÕ¡√–‡À¬®“°„∫¡–°√Ÿ¥‡ªìπ “√ ”§—≠
À√◊ÕÕ“®º ¡°—∫ “√ chlorhexidine ‡æ◊ËÕ‡ √‘¡ƒ∑∏‘Ï

ƒ∑∏‘Ïμâ“π‡™◊ÈÕ·∫§∑’‡√’¬∑’Ë°àÕ‚√§ª√‘∑—πμå¢Õß μàÕ‰ª‰¥â
πÈ”¡—π®“°„∫·≈–‡ª≈◊Õ°º≈¢Õß¡–°√Ÿ¥*
*Wongsariya K, Phanthong P, Bunyapraphatsara
N, Srisukh V, Chomnawang MT. Synergistic in-
°“πμå «ß»“√‘¬–, æ𑥓 æ“π∑Õß, π—π∑«—π ∫ÿ≠¬ª√–
teraction and mode of action of Citrus hystrix
¿—»√, «‘¡≈ »√’»ÿ¢, ¡—≈≈‘°“ ‰μ√‡¥™ ™¡π“«—ß essential oil against bacteria causing periodon-
tal diseases. Pharmaceutical Biology. 2014;52(3):
§≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬¡À‘¥≈ 273-80.

Pharmaceutical Biology. 2014;52(3):273-280.

º≈·≈–„∫®“°μâπ¡–°√Ÿ¥ (Citrus hystrix DC.)
ƒ∑∏‘ω≈à¬ÿß∑’ˇªìπæ“À–π”‚√§„π¡πÿ…¬å¢Õß
¡—°„™â‡ªìπ‡§√◊ËÕߪ√ÿß·μàßÕ“À“√ ·≈–‡¢â“‡§√◊ËÕ߬“
πÈ”¡—πÀÕ¡√–‡À¬®“°„∫·≈–‡ª≈◊Õ°º≈¡–°√Ÿ¥*
·ºπ‰∑¬ ´÷Ëß®“°°“√»÷°…“æ∫«à“ƒ∑∏‘Ï∑“߬“¥â“πÀπ÷Ëß
†
®‘‚√® π√–√—°…å*, ÿπ—¬π“ ∑â“π‰μ√¿æ , ¡≥±“∑‘æ¬å
§◊Õ “¡“√∂μâ“π‡™◊ÈÕ·∫§∑’‡√’¬‰¥â ∑”„À⺟⫑®—¬°≈ÿà¡π’È
1
‡
,¶
§ß¡’ , Michael J. Bangs* , ∏’√¿“æ ‡®√‘≠«‘√‘¬–¿“æ
π„®∑’Ë®–»÷°…“πÈ”¡—πÀÕ¡√–‡À¬®“°„∫·≈–‡ª≈◊Õ°
º≈¡–°√Ÿ¥ ‡æ◊ËÕπ”¡“„™â„π°“√μâ“π‡™◊ÈÕ·∫§∑’‡√’¬∑’Ë *§≥–‡°…μ√ ¡À“«‘∑¬“≈—¬‡°…μ√»“ μ√å
†
°àÕ„À⇰‘¥‚√§ª√‘∑—πμå„π™àÕߪ“° ´÷Ëߺ≈°“√»÷°…“ °√¡«‘∑¬“»“ μ√å°“√·æ∑¬å °√–∑√«ß “∏“√≥ ÿ¢
‡
æ∫«à“ πÈ”¡—πÀÕ¡√–‡À¬®“°„∫¡–°√Ÿ¥¡’ƒ∑∏‘Ïμâ“π §≥–‡°…μ√ °”·æß· π ¡À“«‘∑¬“≈—¬‡°…μ√»“ μ√å