Page 110 - journal-8-2-S-Full
P. 110
ÒÙ «“√ “√°“√·æ∑¬å·ºπ‰∑¬·≈–°“√·æ∑¬å∑“߇≈◊Õ° ªï∑’Ë ¯©∫—∫∑’Ë Ú æƒ…¿“§¡- ‘ßÀ“§¡ (©∫—∫‡ √‘¡) ÚııÛ
°“√»÷°…“ƒ∑∏‘Ïμâ“π‡´≈≈å¡–‡√ÁߢÕß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ·≈– ªÕ√å‡ÀÁ¥À≈‘π®◊Õ„πÀ≈Õ¥∑¥≈Õß
Ò Ú Ò
°…¡“ ÿ¢“¿‘√¡¬å , πæ¡“» ÿπ∑√‡®√‘≠ππ∑å , ‚°«‘∑ æ—≤π“ªí≠≠“ —μ¬å
Ò
Àπ૬‡§√◊ËÕß¡◊Õæ‘‡»…‡æ◊ËÕ°“√«‘®—¬ ∂“π à߇ √‘¡°“√«‘®—¬ §≥–·æ∑¬»“ μ√廑√‘√“™æ¬“∫“≈ ¡À“«‘∑¬“≈—¬¡À‘¥≈
Ú
¿“§«‘™“‡¿ —™«‘π‘®©—¬ §≥–‡¿ —™»“ μ√å ¡À“«‘∑¬“≈—¬¡À‘¥≈
À≈—°°“√·≈–‡Àμÿº≈ ‡ÀÁ¥À≈‘π®◊Õ (Ganoderma lucidum (Fr.) Karst.) À√◊Õ‡ÀÁ¥À¡◊Ëπªï ‡ªìπ ¡ÿπ‰æ√®’π∑’Ë¡’°“√„™â„π°“√
ªÑÕß°—π·≈–√—°…“‚√§¡“π“ππ—∫æ—πªï ¡’√“¬ß“π°“√»÷°…“¡“°¡“¬∑’ˇ°’ˬ«¢âÕß°—∫ƒ∑∏‘Ï¢Õß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ æ∫«à“ “√ °—¥
À¬“∫®“°‡ÀÁ¥À≈‘π®◊Õ¡’ƒ∑∏‘Ï∑—Èßμâ“π°“√Õ—°‡ ∫ hepatoprotective μâ“π·∫§∑’‡√’¬·°√¡∫«° μâ“π‰«√— œ≈œ ·≈–¡’ƒ∑∏‘Ï ”§—≠„π
°“√μâ“π¡–‡√Áß (anti-cancer) ·≈–°√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π (immunomodulatory)°“√»÷°…“ƒ∑∏‘Ïμâ“π¡–‡√ÁߢÕß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ
æ∫«à“ “¡“√∂¬—∫¬—Èß°“√‡®√‘≠¢Õß∑—È߇´≈≈å¡–‡√Áß∑“ß‚≈À‘μ«‘∑¬“·≈–‡´≈≈å¡–‡√Áß™π‘¥ solid tumor ‰¥â §≥–ºŸâ«‘®—¬®÷߇ÀÁπ ¡§«√
»÷°…“«‘®—¬°“√∑¥ Õ∫ƒ∑∏‘ϰ√–μÿâπ¿Ÿ¡‘§ÿâ¡°—π·≈–μâ“π¡–‡√ÁߢÕ߇ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿå∑’Ëπ”‡¢â“¡“ª≈Ÿ°„πª√–‡∑»‰∑¬ ‡æ◊ËÕæ—≤π“π”
‰ª„™âª√–‚¬™πåμàÕ‰ª
«—μ∂ÿª√– ß§å ‡æ◊ËÕ∑¥ Õ∫ƒ∑∏‘Ïμâ“π¡–‡√ÁߢÕß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ·≈– ªÕ√å‡ÀÁ¥À≈‘π®◊Õ “¬æ—π∏ÿåμà“ß Ê ∑’Ëπ”‡¢â“¡“ª≈Ÿ°
„πª√–‡∑»
«‘∏’°“√¥”‡π‘π°“√ π” “√ °—¥πÈ”¢Õ߇ÀÁ¥À≈‘π®◊Õ (¥Õ°‡ÀÁ¥·≈– ªÕ√å¢Õß “¬æ—π∏ÿå MG1, MG2, MG5, MG6) ®”π«π Ò˜
μ—«Õ¬à“ß ·≈– “√ °—¥‡Õ∑“πÕ≈ ( ªÕ√å∑’˰–‡∑“–¢Õß “¬æ—π∏ÿå MG1, MG2, MG5) ®”π«π Û μ—«Õ¬à“ß¡“‡≈’Ȭß√à«¡°—∫‡´≈≈å¡–‡√Áß
‚≈À‘μ K562 (Human erythromyeloblastoid leukemia) ·≈–‡´≈≈å¡–‡√Áß™π‘¥ solid tumor SKBR3 (¡–‡√Á߇μâ“π¡) ·≈–
μ√«® Õ∫°“√‡°‘¥°“√쓬¢Õ߇´≈≈å·∫∫ apoptosis ‚¥¬°“√¬âÕ¡¥â«¬ “√‡√◊Õß· ß·≈–«‘‡§√“–Àå¥â«¬‡§√◊ËÕß‚ø≈‰´‚μ¡‘‡μÕ√å
º≈°“√»÷°…“ ‡¡◊ËÕ∑¥ Õ∫ƒ∑∏‘Ïμâ“π¡–‡√ÁߢÕß “√ °—¥®“°‡ÀÁ¥À≈‘π®◊Õ„π‡´≈≈å¡–‡√Áß‚≈À‘μ K562 ‡ª√’¬∫‡∑’¬∫°—∫‡´≈≈å∑’ˉ¡à
‰¥â‡≈’Ȭß√à«¡°—∫ “√ °—¥ æ∫«à“ “√ °—¥πÈ”¢Õ߇ÀÁ¥À≈‘π®◊Õ·≈– “√ °—¥‡Õ∑“πÕ≈ ‰¡à¡’ƒ∑∏‘Ï∑”„À⇰‘¥°“√쓬·∫∫ apoptosis „π
¢≥–∑’Ë “√ °—¥πÈ”·≈–‡Õ∑“πÕ≈ ∑”„À⇴≈≈å¡–‡√Áß™π‘¥ solid tumor SKBR3 쓬‡æ‘Ë¡¢÷Èπ‡¡◊ËÕ‡∑’¬∫°—∫‡´≈≈å¡–‡√Áß∑’ˉ¡à‰¥â‡≈’Ȭß√à«¡
°—∫ “√ °—¥
¢âÕ √ÿª “√ °—¥πÈ”·≈–‡Õ∑“πÕ≈¢Õ߇ÀÁ¥À≈‘π®◊Õ ‰¡à¡’ƒ∑∏‘Ï∑”≈“¬‡´≈≈å¡–‡√Áß‚≈À‘μ K562 ·∫∫ apoptosis ‰¥â ·μà∑”„Àâ
‡´≈≈凴≈≈å¡–‡√Áß™π‘¥ solid tumor SKBR3 쓬·∫∫ apoptosis ‰¥â