Page 93 - journal-8-1-Full

Journal of Thai Traditional & Alternative Medicine Vol. 8 No. 1 January-April 2010 ¯ı

´÷Ë߃∑∏‘Ï¥—ß°≈à“«πà“®–‡ªìπμâπ‡§â“∑’Ë∑”„Àâ¡’°“√„™âæ◊™π’È„π°“√ “√ °—¥®“°¥Õ°¥â«¬‡Õ∑“πÕ≈¡’ƒ∑∏‘Ïμâ“πÕ—°‡ ∫ “¡“√∂

∫”∫—¥√—°…“ºŸâªÉ«¬¡“≈“‡√’¬„π°“√·æ∑¬åæ◊Èπ∫â“π¢ÕßÀ≈“¬ ∫√√‡∑“Õ“°“√Õ—°‡ ∫„πÀπŸ∑’Ë∂Ÿ°‡Àπ’ˬ«π”„À⇪ìπ¢âÕÕ—°‡ ∫
Ú˜
ª√–‡∑». πÕ°®“°π’È ¬—ßæ∫ƒ∑∏‘Ϫ°ªÑÕß/√—°…“‰μ. ®“°æ‘…¢Õß √Ÿ¡“∑Õ¬¥å . “√ °—¥®“°„∫∑’Ë„™â§≈Õ‚√øÕ√å¡, ‡¡∑“πÕ≈ À√◊Õ
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´‘ æ≈“∑‘π ´÷Ë߇ªì𬓇§¡’∫”∫—¥μâ“π¡–‡√Áß∑’Ë¡’æ‘…μàÕ‰μ Ÿß √«¡ Õ’‡∑Õ√凪ìπμ—«∑”≈–≈“¬ °Á¡’ƒ∑∏‘Ï·°âª«¥ ≈¥‰¢â μâ“πÕ—°‡ ∫
Ú¯ ÛÚ
∑—È߃∑∏‘Ϭ—∫¬—Èß°“√°‘πÕ“À“√¢Õß·¡≈ß∫“ß™π‘¥ . à«π°“√«‘®—¬ ‡¡◊ËÕ©’¥‡¢â“™àÕß∑âÕߢÕßÀπŸ∑¥≈Õ߇™àπ°—π . ∑—Èßπ’È ™π‘¥¢Õßμ—«
„À¡à Ê ¡ÿà߇πâπ»÷°…“ƒ∑∏‘Ïμâ“π°“√‡μ‘¡ÕÕ°´‘‡®π·≈–ƒ∑∏‘Ïμâ“π ∑”≈–≈“¬ àߺ≈‚¥¬μ√ßμàÕÕߧåª√–°Õ∫∑“߇§¡’·≈–ƒ∑∏‘Ï∑“ß
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Õπÿ¡Ÿ≈Õ‘ √–§àÕπ¢â“ß¡“° ¥—ß®–°≈à“«„π√“¬≈–‡Õ’¬¥μàÕ‰ª. ™’«¿“æ¢Õß “√ °—¥π—Èπ Ê °≈à“«§◊Õ ƒ∑∏‘Ïμâ“πÕ—°‡ ∫¢Õß “√
°“√»÷°…“∑“ß惰…‡§¡’æ∫«à“æ◊™π’È¡’ “√°≈ÿࡇ∑Õ√åæ’π °—¥∑’Ë„™â§≈Õ‚√øÕ√å¡·≈–Õ’‡∑Õ√凪ìπμ—«∑”≈–≈“¬π—Èππà“®–
·≈–Õπÿæ—π∏å ‡™àπ triterpenes, sesquiterpenes, triterpe- ‡°‘¥®“°Õߧåª√–°Õ∫´÷Ë߇ªìπ°≈ÿà¡ “√‰¡à¡’¢—È« ´÷Ëßæ∫«à“¡’
Òˆ-ÚÙ,Úˆ,Ûˆ,Û¯
noids, terpene glycosides . πÕ°®“°π’Èμ√«® ª√– ‘∑∏‘¿“æ°“√√—°…“„π°√≥’¢Õß°“√Õ—°‡ ∫·∫∫‡√◊ÈÕ√—ß.
æ∫ “√°≈ÿà¡·Õ≈§“≈Õ¬¥å, ·´‚æπ‘π, ‡μ’¬√Õ¬¥å, ‡ø≈‚«πÕ¬¥å, à«π “√ °—¥®“°‡¡∑“πÕ≈´÷Ëß¡’Õߧåª√–°Õ∫‡ªìπ°≈ÿà¡ “√∑’Ë¡’
Ú˜,Û
·∑ππ‘π . ”À√—∫ “√°≈ÿà¡ sesquiterpene lactones ¡’ ¢—È«‡ªìπ à«π„À≠àπ—Èπ‡À¡“–°—∫°√≥’¢Õß°“√Õ—°‡ ∫·∫∫
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‚§√ß √â“ß∑“߇§¡’¥—ß√Ÿª∑’Ë Ò . μ—«Õ¬à“ß “√„π°≈ÿà¡π’È ‡™à𠇩’¬∫æ≈—π¡“°°«à“. πÕ°®“°π’Ȭ—ßæ∫«à“ “√ °—¥„π‡¡∑“πÕ≈
‡«Õ√å‚¡‰≈¥å ´’, ‡«Õ√å‚¡‰≈¥å ¥’, 摪‚∑§“√åøîπ, 8α-tigloyloxy- ·≈–§≈Õ‚√øÕ√å¡¡’ƒ∑∏‘Ï≈¥‰¢â, “√ °—¥„πÕ’‡∑Õ√剡ࡒƒ∑∏‘Ïπ’È.

hirsutinolide-13-O-acetate, 8α-tigloyloxy-hirsutinolide, °“√∑¥ Õ∫‡∫◊ÈÕßμâπæ∫«à“ “√ °—¥„πÕ’‡∑Õ√å·≈–§≈Õ‚√øÕ√å¡
8α-(4-hydroxymethacryloyloxy)-hirsutinolide-13-O-ac- ¡’ à«πª√–°Õ∫‡ªìπ°≈ÿà¡ ‡μ’¬√Õ¬¥å, ·Õ≈§“√Õ¬¥å, ·´‚æπ‘π
etate. ®“°°“√∑¥ Õ∫πÕ°°“¬æ∫ƒ∑∏‘Ïμâ“πæ≈“ ‚¡‡¥’¬¡ „π¢≥–∑’Ë “√°≈ÿࡇø≈‚«πÕ¬¥å ·≈–‡∑Õ√åæ’πÕ¬¥åæ∫„π “√
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‡™◊ÈÕ¡“≈“‡√’¬ Plasmodium falciparum ´÷Ëߥ◊ÈÕ¬“¶≈Õ‚√§§«’π °—¥¥â«¬‡¡∑“πÕ≈ .
‚¥¬ 8α-tigloyloxy-hirsutinolide-13-O-acetate, 8α-(4- °“√»÷°…“ƒ∑∏‘Ïμâ“π·∫§∑’‡√’¬¥â«¬ cup-plate method)
hydroxymethacryloyloxy)-hirsutinolide-13-O-acetate æ∫«à“ “√ °—¥∑’Ë„™â‡∫π´’π‡ªìπμ—«∑”≈–≈“¬¡’ƒ∑∏‘Ïμâ“π·∫§∑’‡√’¬

·≈–‡«Õ√å‚¡‰≈¥å ¥’ ¡’ƒ∑∏‘Ïμâ“π‡™◊ÈÕ¥—ß°≈à“«‰¥â. “√ °—¥∑’Ë„™â ‰¥â∑—Èß·∫§∑’‡√’¬·°√¡∫«°·≈–·°√¡≈∫ ·μà “√ °—¥∑’Ë„™â
„π°“√∑¥ Õ∫‡μ√’¬¡‰¥â®“°¬“μâ¡ ¡’πÈ”‡ªìπ°√– “¬¬“ ·≈– §≈Õ‚√øÕ√å¡, Õ’‡∑Õ√å À√◊Õ‡¡∑“πÕ≈‰¡àæ∫ƒ∑∏‘Ïπ’È. ”À√—∫
‡ªìπ√Ÿª·∫∫¬“∑’Ë„™â°—π∑—Ë«‰ª. °“√§âπæ∫ƒ∑∏‘Ï∑“ß™’«¿“æ¥—ß ª√– ‘∑∏‘º≈°“√μâ“π·∫§∑’‡√’¬¢Õß “√ °—¥æ∫«à“·ª√μ“¡§«“¡

°≈à“«®÷ß∂◊Õ‡ªìπÀ≈—°∞“π∑“ß«‘∑¬“»“ μ√å∑’˙૬¬◊π¬—πº≈°“√ ‡¢â¡¢âπ∑’Ë„™â ·≈–‡¡◊ËÕ‡ª√’¬∫‡∑’¬∫ƒ∑∏‘Ï°—∫§≈Õ·√¡‡øπ‘§Õ≈æ∫
„™â ¡ÿπ‰æ√π’È„π°“√·æ∑¬åæ◊Èπ∫â“π‡æ◊ËÕ√—°…“‚√§¡“≈“‡√’¬‰¥â «à“ “√ °—¥¢π“¥ ı ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√¡’ƒ∑∏‘Ïμâ“π‡™◊ÈÕ

Õ¬à“ߥ’. ºŸâ«‘®—¬‰¥âμ—ÈߢâÕ —߇°μ«à“ “√ °—¥‰¥§≈Õ‚√¡’‡∑π∑’Ë Bacillus subtilis ·≈– Pseudomonas aeruginosa ‰¥â‡∑’¬∫
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·¬°‰¥â®“°°“√μâ¡æ◊™ ¡’ƒ∑∏‘Ïμâ“π¡“≈“‡√’¬¥’°«à“°“√ °—¥æ◊™ ‡∑à“°—∫§≈Õ·√¡‡øπ‘§Õ≈¢π“¥ Ò ‰¡‚§√°√—¡/¡‘≈≈‘≈‘μ√ .
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·Àâß‚¥¬μ√ß . ß“π«‘®—¬™‘Èπ„À¡à Ê ‡πâπ°“√»÷°…“ƒ∑∏‘Ïμâ“π°“√‡μ‘¡
ÕÕ°´‘‡®π·≈–μâ“πÕπÿ¡Ÿ≈Õ‘ √– ‚¥¬°“√»÷°…“„™â∑—Èß√Ÿª·∫∫
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®”≈Õß„π°“¬·≈–πÕ°°“¬ ‡™àπ »÷°…“ª√– ‘∑∏‘¿“æ„π°“√
¬—∫¬—È߇æÕ√åÕÕ°´‘‡¥™—π “√‰¢¡—π, °“√μ√«®À“ total phenolic
content, §«“¡‡ªìπæ‘…μàÕ‡´≈≈å, °“√ª°ªÑÕߥ’‡ÕÁπ‡Õ·≈–‡´≈≈å.
®“°°“√«‘®—¬æ∫«à“ “√ °—¥À¬“∫„π‡Œ°‡´π, §≈Õ‚√øÕ√å¡,

‡¡∑“πÕ≈ À√◊Õ„ππÈ” ≈â«π¡’ ¡∫—μ‘μâ“πÕÕ°´‘‡¥™—π‰¥â¥’. Õߧå
ª√–°Õ∫∑“߇§¡’„π “√ °—¥‡À≈à“π’È “¡“√∂®—∫Õπÿ¡Ÿ≈Õ‘ √–‰¥â
®÷ß “¡“√∂ª°ªÑÕ߇´≈≈å·≈–¥’‡ÕÁπ‡Õ®“°Õ—πμ√“¬‰¥â. „π∑“ß
√Ÿª∑’Ë Ò ‚§√ß √â“ß∑“߇§¡’¢Õß sesquiterpene lactone ®“° Ver-
nonia cinerea Ûˆ §≈‘π‘° “√∑’Ë¡’ ¡∫—쑇™àππ’Èπà“®–¡’»—°¬¿“æ„π°“√ªÑÕß°—πÀ√◊Õ