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Abstract
Chemical Constituents, Biological Activity of Vernonia cinerea (L.) Less., and its Formulation
Development as a Smoking Cessation Aid
Ornlaksana Paeratakul*
*Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, Thailand
Vernonia cinerea (L.) Less. (VC) [common name: little ironweed; Asteraceae] is a perennial herbaceous
plant distributed in tropical regions and commonly found in Southeast Asia. In Thailand, VC has been used in
both traditional and complementary medicine as an aid in smoking cessation treatment. Various parts of the
plant containing a variety of chemical constituents have found many therapeutic uses in different aspects of
traditional medicine. However, its active components and mechanism of action, particularly in smoking cessa-
tion, remain unclear. This review article describes VC with respect to its botanical data, therapeutic uses in
traditional medicine, chemical constituents and their respective biological activities, related clinical studies,
and the formulation techniques for developing VC as a smoking cessation aid.
Key words: Vernonia cinerea, smoking cessation