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644 วารสารการแพทย์แผนไทยและการแพทย์ ทางเลือก ปีที่ 21 ฉบับที่ 3 กันยายน-ธันวาคม 2566

Table 2 Cytotoxic activity against six cancer cell lines and normal cell lines of the crude extracts and the fractions of
B. alba and B. rubra extracts.

Sample IC 50 (µg/mL)
KB KATO III SW480 LS 174T KKU-M156 Hep G2 HaCaT

FAE 39.31 ± 33.82 ± 31.54 ± 63.06 ± 33.79 ± 59.63 ± 94.14 ±
2.97 1.19 4.15 5.81 0.55 5.26 1.95
[SI = 2.39] [SI = 2.78] [SI = 2.98] [SI = 1.49] [SI = 2.79] [SI = 1.58]

FAE (H) > 100 > 100 > 100 75.88 ± 3.65 62.22 ± 3.00 > 100 > 100
[SI = NV] [SI = NV] [SI = NV] [SI = 1.32] [SI = 1.61] [SI = NV]
FAE (C) > 100 -
[SI = NV]
FAE (C:E) 5.22 ± 6.04 ± 5.36 ± 5.90 ± 6.00 ± 5.59 ± 8.38 ±
0.24* 0.40* 0.14* 0.73* 0.08* 0.09* 0.62
[SI = 1.60] [SI = 1.39] [SI = 1.56] [SI = 1.42] [SI = 1.40] [SI = 1.50]
FAE (W) > 100 -
[SI = NV]
FRE > 100 65.97 ± 52.76 ± > 100 83.68 ± 94.74 ± > 100
[SI = NV] 1.97 2.32 [SI = NV] 2.94 1.97
[SI = 1.52] [SI = 1.90] [SI = 1.20] [SI = 1.06]
FRE (H) 74.20 ± 35.70 ± 34.71 ± 43.78 ± 41.53 ± 2.60 ± 84.90 ±
4.41 1.80 0.72 4.03 2.29 4 3.26 6.54
[SI = 1.14] [SI = 2.38] [SI = 2.45] [SI = 1.94] [SI = 2.04] [SI = 1.99]
FRE (C) 30.35 ± 6.21 ± 5.21 ± 23.59 ± 11.48 ± 31.07 ± 48.46 ±
1.35 0.65* 0.82* 2.52 1.08* 0.61 1.91
[SI = 1.60] [SI = 7.81] [SI = 9.30] [SI = 2.05] [SI = 4.22] [SI = 1.56]
FRE (E) > 100 -
[SI = NV]
FRE (B) > 100 -
[SI = NV]

FRE (W) > 100 -
[SI = NV]

All the value expressed as mean ± SEM (n = 3), SI = selective index calculated by IC50 of normal cell lines (HaCaT)/ IC50 values
of cancer cell lines, NV = no value since highest concentration 100 µg/mL showed < 50% inhibition of growth. * Showed significant
differences compared to the crude extracts and the other fractions depend on the cell line (p-value < 0.05).